Doxepin

Generic Name
Doxepin
Brand Names
Prudoxin, Silenor, Sinequan, Zonalon
Drug Type
Small Molecule
Chemical Formula
C19H21NO
CAS Number
1668-19-5
Unique Ingredient Identifier
5ASJ6HUZ7D
Background

Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to cidoxepin. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture.
...

Indication

Oral doxepin is approved for the following indications:

Topical doxepin is also approved for short-term (up to 8 days) management of moderate pruritus in adult patients with atopic dermatitis, pruritus or lichen simplex chronicus.

Off-label, doxepin is used topically for the management of neuropathic pain.
...

Associated Conditions
Anxiety, Bipolar Disorder (BD), Depression, Depression, Involutional, Insomnia, Lichen simplex chronicus, Neuropathic Pain, Neurotic depression, Pruritus, Psychotic depressive disorder
Associated Therapies
-
Clinical Trials
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Comparison of Gabapentin With Doxepin in the Management of Uremic Pruritus

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