Imipramine

Generic Name
Imipramine
Brand Names
Tofranil
Drug Type
Small Molecule
Chemical Formula
C19H24N2
CAS Number
50-49-7
Unique Ingredient Identifier
OGG85SX4E4
Background

Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, imipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, i...

Indication

For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older .
...

Associated Conditions
Attention Deficit Hyperactivity Disorder (ADHD), Bulimia Nervosa, Depression, Enuresis, Neuropathic Pain, Panic Disorder
Associated Therapies
-
Clinical Trials
Related News

New Treatment for Nocturnal Enuresis in Children

Not Applicable
Recruiting
Conditions
Nocturnal Enuresis in Children
Interventions
Drug: Sulbutiamine
Drug: Imipramine
First Posted Date
2024-07-12
Last Posted Date
2024-07-12
Lead Sponsor
Sohag University
Target Recruit Count
450
Registration Number
NCT06497647
Locations
🇪🇬

Sohag Faculty of Medecine, Sohag, Egypt

Evaluating Use of Topical Imipramine and Amitriptyline in Reducing Ultraviolet B Light-Induced Redness in Patients With Rosacea

Phase 2
Recruiting
Conditions
Rosacea
Interventions
Drug: Imipramine
Drug: Amitriptyline
Drug: Vehicle
First Posted Date
2024-03-15
Last Posted Date
2024-11-14
Lead Sponsor
Wright State University
Target Recruit Count
48
Registration Number
NCT06312813
Locations
🇺🇸

Wright State Physicians, Fairborn, Ohio, United States

The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy

First Posted Date
2023-01-18
Last Posted Date
2024-04-24
Lead Sponsor
Wright State University
Target Recruit Count
24
Registration Number
NCT05688904
Locations
🇺🇸

Wright State Physicians, Fairborn, Ohio, United States

Therapeutic Efficacy in Women With Stress Urinary Incontinence

First Posted Date
2023-01-10
Last Posted Date
2023-05-19
Lead Sponsor
Far Eastern Memorial Hospital
Target Recruit Count
90
Registration Number
NCT05677295
Locations
🇨🇳

Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao, New Taipei, Taiwan

Comparisons of the Impact of Duloxetine Versus Imipramine on Therapeutic Efficacy, Psychological Distress, Sexual Function, Urethral and Bladder Wall Structure and Blood Flow in Women With Stress Urinary Incontinence: a Randomized Controlled Study

First Posted Date
2020-06-02
Last Posted Date
2022-08-17
Lead Sponsor
Far Eastern Memorial Hospital
Registration Number
NCT04412876
Locations
🇨🇳

Department of Obstetrics and Gynecology, Far-Eastern Memorial Hospital, Banqiao, New Taipei, Taiwan

Imipramine on ER+ve and Triple Negative Breast Cancer

Early Phase 1
Completed
Conditions
Breast Cancer
Interventions
Drug: Imipramine
First Posted Date
2017-04-20
Last Posted Date
2023-06-28
Lead Sponsor
The University of Texas Health Science Center at San Antonio
Target Recruit Count
17
Registration Number
NCT03122444
Locations
🇺🇸

Mays Cancer Center, UT Health San Antonio, San Antonio, Texas, United States

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3
Terminated
Conditions
Dementia
Depression
Schizophrenia
Psychosomatic Disorders
Anxiety Disorders
Interventions
Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium
First Posted Date
2015-03-02
Last Posted Date
2018-02-28
Lead Sponsor
Hannover Medical School
Target Recruit Count
407
Registration Number
NCT02374567
Locations
🇩🇪

Bezirkskrankenhaus Augsburg, Augsburg, Germany

🇩🇪

Krankenhaus Hedwigshöhe, Berlin, Germany

🇩🇪

Hannover Medical School, Hannover, Germany

and more 2 locations

Interpersonal Psychotherapy for Treatment Resistant Depression

First Posted Date
2013-07-11
Last Posted Date
2013-07-11
Lead Sponsor
Hospital de Clinicas de Porto Alegre
Target Recruit Count
74
Registration Number
NCT01896349
Locations
🇧🇷

Federal University of Rio Grande do Sul / Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil

Efficacy of Imipramine for Treatment of Patients With Esophageal Hypersensitivity/ Functional Heartburn

Phase 3
Completed
Conditions
Gastroesophageal Reflux Disease
Interventions
Drug: imipramine
First Posted Date
2012-12-20
Last Posted Date
2014-08-18
Lead Sponsor
Mahidol University
Target Recruit Count
83
Registration Number
NCT01753128
Locations
🇹🇭

Medical Institue; Siriraj Hospital, Bangkok, Thailand

Linking Altered Central Pain Processing and Genetic Polymorphism to Drug Efficacy in Chronic Low Back Pain (Predictio)

First Posted Date
2010-08-11
Last Posted Date
2016-04-06
Lead Sponsor
Insel Gruppe AG, University Hospital Bern
Target Recruit Count
150
Registration Number
NCT01179828
Locations
🇨🇭

Andreas Siegenthaler, Dep. of Anesthesiolgy and Pain therapy, Bern University Hospital, Switzerland

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