Trimethaphan

Generic Name
Trimethaphan
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C22H25N2OS
CAS Number
7187-66-8
Unique Ingredient Identifier
6G8X656T45
Background

A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery.

Indication

For the controlled reduction of blood pressure during surgery and in the treatment of hypertensive emergencies.

Associated Conditions
-
Associated Therapies
-
Clinical Trials
Related News

Autonomic Blockade and Endogenous Glucose Production

Phase 1
Withdrawn
Conditions
Insulin Resistance
Interventions
Other: Saline
Drug: Trimethaphan
First Posted Date
2017-01-23
Last Posted Date
2021-06-08
Lead Sponsor
Vanderbilt University Medical Center
Registration Number
NCT03028571
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic

First Posted Date
2016-04-04
Last Posted Date
2024-10-31
Lead Sponsor
Vanderbilt University
Target Recruit Count
2
Registration Number
NCT02726711
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Role of Sympathetic Activity and Splanchnic Capacitance in Hypertension

Phase 1
Active, not recruiting
Conditions
Hypertension
Interventions
Drug: Trimethaphan
Drug: Nitroglycerin
First Posted Date
2015-04-24
Last Posted Date
2024-08-09
Lead Sponsor
Vanderbilt University
Target Recruit Count
12
Registration Number
NCT02425566
Locations
🇺🇸

Autonomic Dysfunction Center, Nashville, Tennessee, United States

Cardiovascular Effects of Angiotensin (1-7) in Essential Hypertension

First Posted Date
2014-09-19
Last Posted Date
2024-01-09
Lead Sponsor
Vanderbilt University
Target Recruit Count
24
Registration Number
NCT02245230
Locations
🇺🇸

Vanderbilt University, Nashville, Tennessee, United States

Autonomic Nervous System and Nitric Oxide Interactions

Phase 1
Completed
Conditions
Endothelial Dysfunction
Interventions
Drug: Placebo
Drug: Trimethaphan
First Posted Date
2010-06-04
Last Posted Date
2018-02-28
Lead Sponsor
Vanderbilt University
Target Recruit Count
21
Registration Number
NCT01137253
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Pathophysiology of Cardiometabolic Risk Factors in African Americans

Phase 1
Completed
Conditions
Obesity
Hypertension
Interventions
Drug: L-NMMA
Drug: Trimethaphan
First Posted Date
2010-05-13
Last Posted Date
2017-01-18
Lead Sponsor
Vanderbilt University Medical Center
Target Recruit Count
34
Registration Number
NCT01122407
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Nitric Oxide and the Autonomic Nervous System

Not Applicable
Completed
Conditions
Hypertension
Pure Autonomic Failure
Interventions
Drug: L-NMMA
Drug: Trimethaphan
First Posted Date
2005-09-15
Last Posted Date
2013-06-04
Lead Sponsor
Vanderbilt University
Target Recruit Count
112
Registration Number
NCT00178919
Locations
🇺🇸

Autonomic Dysfunction Center, Nashville, Tennessee, United States

The Autonomic Nervous System and Obesity

First Posted Date
2005-09-15
Last Posted Date
2018-03-01
Lead Sponsor
Vanderbilt University
Target Recruit Count
128
Registration Number
NCT00179023
Locations
🇺🇸

Vanderbilt University, Nashville, Tennessee, United States

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