Sinecatechins
- Generic Name
- Sinecatechins
- Brand Names
- Veregen
- Drug Type
- Small Molecule
- Chemical Formula
- -
- CAS Number
- 188265-33-0
- Unique Ingredient Identifier
- T432289GYZ
- Background
Sinecatechins is a botanical drug product for topical use. It is a partially purified fraction of the water extract of green tea leaves from Camellia sinensis, and is a mixture of catechins and other green tea components. Catechins constitute 85 to 95% (by weight) of the total drug substance which includes more than 55% of Epigallocatechin gallate (EGCg), other catechin derivatives such as Epicatechin (EC), Epigallocatechin (EGC), Epicatechin gallate (ECg) and some additional minor catechin derivatives i.e. Gallocatechin gallate (GCg), Gallocatechin (GC), Catechin gallate (Cg), and Catechin (C). In addition to the known catechin components, it also contains gallic acid, caffeine, and theobromine which together constitute about 2.5% of the drug substance. The remaining amount of the drug substance contains undefined botanical constituents derived from green tea leaves.
- Indication
For the topical treatment of external genital and perianal warts (Condylomata acuminata) in immunocompetent patients 18 years and older.
- Associated Conditions
- Condylomata Acuminata, Perianal Warts
- Associated Therapies
- -
To Evaluate if Green Tea Can be Effective in Reducing the Progression of Prostate Cancer in Men on Close Monitoring
- Conditions
- Interventions
- First Posted Date
- 2020-10-22
- Last Posted Date
- 2024-08-09
- Lead Sponsor
- ECOG-ACRIN Cancer Research Group
- Target Recruit Count
- 360
- Registration Number
- NCT04597359
- Locations
- 🇺🇸
Bethesda North Hospital, Cincinnati, Ohio, United States
🇺🇸Abbott-Northwestern Hospital, Minneapolis, Minnesota, United States
🇺🇸Cheyenne Regional Medical Center-West, Cheyenne, Wyoming, United States
Systemic Exposure of Catechins From Veregen 15% Ointment in Patients With External Anogenital Warts and From Oral Intake of Green Tea Beverage in Healthy Volunteers
- First Posted Date
- 2011-12-12
- Last Posted Date
- 2012-04-19
- Lead Sponsor
- MediGene
- Target Recruit Count
- 30
- Registration Number
- NCT01490008
- Locations
- 🇩🇪
CardioSec Clinical Reasearch GmbH, Erfurt, Germany
Safety and Neuroprotective Effects of Polyphenon E in MS; Phase II
- First Posted Date
- 2011-10-14
- Last Posted Date
- 2014-03-14
- Target Recruit Count
- 11
- Registration Number
- NCT01451723
- Locations
- 🇺🇸
LSu Health Sciences Center, New Orleans, Louisiana, United States
Study to Evaluate Safety and Toxicity of Polyphenon E (EGCG) in HIV-1-Infected Individuals
- First Posted Date
- 2011-09-13
- Last Posted Date
- 2023-05-19
- Lead Sponsor
- Baylor College of Medicine
- Target Recruit Count
- 23
- Registration Number
- NCT01433289
- Locations
- 🇺🇸
University of Texas Health Science Center Houston, Houston, Texas, United States
🇺🇸Baylor College of Medicine, Houston, Texas, United States
A Pilot Study of Chemo-prevention of Green Tea in Women With Ductal Carcinoma in Situ
- First Posted Date
- 2010-02-02
- Last Posted Date
- 2020-04-09
- Lead Sponsor
- University of Chicago
- Target Recruit Count
- 20
- Registration Number
- NCT01060345
- Locations
- 🇺🇸
The University of Chicago, Chicago, Illinois, United States
Safety of Polyphenon E in Multiple Sclerosis Pilot Study
- First Posted Date
- 2009-02-04
- Last Posted Date
- 2013-06-27
- Target Recruit Count
- 10
- Registration Number
- NCT00836719
- Locations
- 🇺🇸
Louisiana Health Sciences Center New Orleans, New Orleans, Louisiana, United States
Study of Polyphenon E in Addition to Erlotinib in Advanced Non Small Cell Lung Cancer
- First Posted Date
- 2008-06-30
- Last Posted Date
- 2015-04-21
- Target Recruit Count
- 11
- Registration Number
- NCT00707252
- Locations
- 🇺🇸
LSUHSC-Shreveport, Feist-Weiller Cancer Center, Shreveport, Louisiana, United States
A Study of the Effect of Polyphenon E (Green Tea Extract) on Breast Cancer Progression
- First Posted Date
- 2008-05-13
- Last Posted Date
- 2017-09-21
- Target Recruit Count
- 32
- Registration Number
- NCT00676793
- Locations
- 🇺🇸
LSU Health Sciences Center, Shreveport, Louisiana, United States
🇺🇸Columbia Presbyterian Hospital, New York, New York, United States
Study of Polyphenon E in Men With High-grade Prostatic Intraepithelial Neoplasia
- First Posted Date
- 2008-01-16
- Last Posted Date
- 2019-10-04
- Target Recruit Count
- 97
- Registration Number
- NCT00596011
- Locations
- 🇺🇸
LSU Health Sciences Center, Feist-Weiller Cancer Center, Shreveport, Louisiana, United States
🇺🇸Jefferson Medical College - Department of Urology, Philadelphia, Pennsylvania, United States
🇺🇸University of Chicago - Department of Surgery, Chicago, Illinois, United States
Green Tea or Polyphenon E in Preventing Lung Cancer in Former Smokers With Chronic Obstructive Pulmonary Disease
- Conditions
- Interventions
- First Posted Date
- 2006-08-15
- Last Posted Date
- 2013-11-28
- Lead Sponsor
- Sherry Chow
- Target Recruit Count
- 178
- Registration Number
- NCT00363805
- Locations
- 🇺🇸
Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson, Arizona, United States
🇺🇸Veterans Affairs Medical Center - Tucson, Tucson, Arizona, United States
🇺🇸Virginia G. Piper Cancer Center at Scottsdale Healthcare - Shea, Tucson, Arizona, United States
Drug Development Updates
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