Mecasermin
- Generic Name
- Mecasermin
- Brand Names
- Increlex
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 68562-41-4
- Unique Ingredient Identifier
- 7GR9I2683O
- Background
Mecasermin contains recombinant-DNA-engineered human insulin-like growth factor-1 (rhIGF-1). IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence of the product is identical to that of endogenous human IGF-1. The rhIGF-1 protein is synthesized in bacteri...
- Indication
For the long-term treatment of growth failure in pediatric patients with Primary IGFD or with GH gene deletion who have developed neutralizing antibodies to GH . It is not indicated to treat Secondary IGFD resulting from GH deficiency, malnutrition, hypothyroidism or other causes; it is not a substitute for GH therapy.
- Associated Conditions
- Primary Insulin-like Growth Factor-1 Deficiency
- Associated Therapies
- -
Gene Expression Changes In Young and Geriatric Skin
- Conditions
- Interventions
- First Posted Date
- 2019-04-30
- Last Posted Date
- 2024-01-10
- Lead Sponsor
- Wright State University
- Target Recruit Count
- 24
- Registration Number
- NCT03932162
- Locations
- 🇺🇸
Wright State Physicians, Fairborn, Ohio, United States
IGF-I Stimulation of Collagen Synthesis in Ehlers-Danlos Patients
- Conditions
- Interventions
- First Posted Date
- 2011-10-05
- Last Posted Date
- 2012-11-20
- Lead Sponsor
- Bispebjerg Hospital
- Target Recruit Count
- 15
- Registration Number
- NCT01446783
- Locations
- 🇩🇰
Institute of Sportsmedicine Copenhagen, Copenhagen, Denmark
Evaluation of the Safety and Efficacy of Using Insulin-like Growth Factor-1 in Patients With a Heart Attack
- Conditions
- Interventions
- First Posted Date
- 2011-09-21
- Last Posted Date
- 2017-03-30
- Lead Sponsor
- University College Cork
- Target Recruit Count
- 47
- Registration Number
- NCT01438086
- Locations
- 🇳🇱
Leiden University Medical Center, Leiden, Netherlands
🇮🇪Cork University Hospital, Cork, Ireland
Effects of IGF-I in HIV Metabolic Disease
- First Posted Date
- 2011-04-06
- Last Posted Date
- 2016-03-23
- Lead Sponsor
- University of Texas Southwestern Medical Center
- Target Recruit Count
- 16
- Registration Number
- NCT01329744
- Locations
- 🇺🇸
University of Texas Southwestern Medical Center, Dallas, Texas, United States
Long-Term Treatment With rhIGF-1 in GHIS
- First Posted Date
- 2007-12-12
- Last Posted Date
- 2023-07-06
- Lead Sponsor
- Ipsen
- Target Recruit Count
- 92
- Registration Number
- NCT00571727
- Locations
- 🇺🇸
Ipsen, Brisbane, California, United States
Drug Development Updates
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