Tetrabenazine
- Generic Name
- Tetrabenazine
- Brand Names
- Nitoman, Xenazine
- Drug Type
- Small Molecule
- Chemical Formula
- C19H27NO3
- CAS Number
- 58-46-8
- Unique Ingredient Identifier
- Z9O08YRN8O
- Background
A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008.
- Indication
Treatment of hyperkinetic movement disorders like chorea in Huntington's disease, hemiballismus, senile chorea, Tourette syndrome and other tic disorders, and tardive dyskinesia
- Associated Conditions
- Gilles de la Tourette's Syndrome, Hemiballismus, Huntington's Disease (HD), Tardive Dyskinesia (TD), Senile chorea
- Associated Therapies
- -
A Pilot Study Assessing Impulsivity in Patients With Huntington's Disease on Xenazine (Tetrabenazine)
- First Posted Date
- 2015-07-28
- Last Posted Date
- 2022-09-02
- Lead Sponsor
- William Ondo, MD
- Target Recruit Count
- 20
- Registration Number
- NCT02509793
- Locations
- 🇺🇸
Methodist Neurological Institute, Houston, Texas, United States
Xenazine in Late Dyskinetic Syndrome With Neuroleptics
- First Posted Date
- 2012-03-02
- Last Posted Date
- 2017-09-12
- Lead Sponsor
- Centre Hospitalier Universitaire, Amiens
- Target Recruit Count
- 54
- Registration Number
- NCT01543321
- Locations
- 🇫🇷
CHU Strasbourg, Strasbourg, France
🇫🇷CH des Charpennes, Lyon, France
🇫🇷CHU Toulouse, Toulouse, France
Compassionate Use of Tetrabenazine in the Treatment of Abnormal Movements
- Conditions
- First Posted Date
- 2008-03-24
- Last Posted Date
- 2023-03-24
- Lead Sponsor
- Joseph Jankovic
- Registration Number
- NCT00642057
Neuroleptic and Huntington Disease Comparison of : Olanzapine, la Tetrabenazine and Tiapride
- Conditions
- Interventions
- First Posted Date
- 2008-03-11
- Last Posted Date
- 2018-01-19
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 180
- Registration Number
- NCT00632645
- Locations
- 🇫🇷
CHU Henri Mondor, Creteil, France
Tetrabenazine for Partial Responders
- Conditions
- First Posted Date
- 2006-08-10
- Last Posted Date
- 2012-07-06
- Lead Sponsor
- Centre for Addiction and Mental Health
- Target Recruit Count
- 41
- Registration Number
- NCT00362804
- Locations
- 🇨🇦
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Drug Development Updates
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