Adecatumumab is a recombinant human monoclonal antibody of the IgG1 subclass with a binding specificity to epithelial cell adhesion molecule (EpCAM). EpCAM (CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian, pancreatic and lung cancer.
Investigated for use/treatment in breast cancer and prostate cancer.
Klinikum der Johannes-Gutenberg Universität, Mainz, Germany
Klinikum Mannheim GmbH Universitätsklinikum, Mannheim, Germany
Universitätsklinikum der LMU Grosshadern, München, Germany
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