Although leptin is a circulating signal that reduces appetite, in general, obese people have an unusually high circulating concentration of leptin. These people are said to be resistant to the effects of leptin, in much the same way that people with type 2 diabetes are resistant to the effects of insulin. Thus, obesity develops when people take in more energ...
Investigated for use/treatment in lipodystrophy and obesity.
Rockefeller University Hospital, New York, New York, United States
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