PTC299 is a novel, orally administered small-molecule designed to inhibit the production of vascular endothelial growth factor (VEGF) in tumors. Overexpression of VEGF plays a key role in multiple diseases including cancer and macular degeneration. PTC299 was discovered through PTC's GEMS technology by targeting the post-transcriptional processes that regulate VEGF formation, and is currently being developed for the treatment of cancer.
Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors.
University of Massachusetts Memorial Health Care, Worcester, Massachusetts, United States
Fundación Santa Fe de Bogotá, Bogotá, Colombia
Clinique Saint Pierre, Ottignies, Belgium
Gabrail Cancer Center, Canton, Ohio, United States
SCRI Tennessee Oncology, Nashville, Tennessee, United States
University of Rochester MC, Rochester, New York, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
New York University Clinical Cancer Center, New York, New York, United States
Indiana University Simon Cancer Center, Indianapolis, Indiana, United States
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
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