Cariprazine

Generic Name
Cariprazine
Brand Names
Vraylar, Reagila
Drug Type
Small Molecule
Chemical Formula
C21H32Cl2N4O
CAS Number
839712-12-8
Unique Ingredient Identifier
F6RJL8B278
Background

Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT receptors and as an antagonist at serotonin 5-HT receptors. Cariprazine has been investigated in a variety of psychiatric disorders, including schizophrenia, bipo...

Indication

Cariprazine is indicated for the treatment of schizophrenia in adults to manage both positive and negative symptoms. It is also indicated to monotherapy for acute management of manic or mixed episodes associated with bipolar I disorder (bipolar mania) in adults, and acute management of depressive episodes associated with bipolar I disorder (bipolar depressio...

Associated Conditions
Bipolar Disorder With Manic or Mixed Episodes, Depressive Episodes, Schizophrenia
Associated Therapies
-

Cariprazine Pediatric ASD PK Study

Phase 1
Completed
Conditions
Interventions
First Posted Date
2020-05-11
Last Posted Date
2022-04-12
Lead Sponsor
AbbVie
Target Recruit Count
24
Registration Number
NCT04382885
Locations
🇺🇸

Atlanta Center for Medical Research /ID# 233576, Atlanta, Georgia, United States

🇺🇸

iResearch Atlanta, LLC /ID# 233614, Decatur, Georgia, United States

🇺🇸

Neuropsychiatric Research Center of Orange County /ID# 233663, Orange, California, United States

Efficacy and Safety of Cariprazine in the Treatment of Adolescent Participants (13 to 17 Years of Age) With Schizophrenia

Phase 3
Recruiting
Conditions
Interventions
First Posted Date
2019-01-25
Last Posted Date
2024-12-17
Lead Sponsor
Gedeon Richter Plc.
Target Recruit Count
330
Registration Number
NCT03817502
Locations
🇷🇺

SBHI of Moscow Region "Central Clinical Psychiatric Hospital", Moscow, Russian Federation

🇷🇺

Clinical Psychiatry Hospital #1 of Nizhniy Novgorod, Nizhny Novgorod, Russian Federation

🇷🇺

State Public Institution of Healthcare Leningrad Regional Psychoneurological Dispensary, Roshchino, Russian Federation

and more 54 locations

Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD) Who Have Had an Inadequate Response to Antidepressants Alone

Phase 3
Completed
Conditions
Interventions
First Posted Date
2018-11-13
Last Posted Date
2022-10-25
Lead Sponsor
AbbVie
Target Recruit Count
759
Registration Number
NCT03738215
Locations
🇺🇸

Lehigh Center for Clinical Research /ID# 236702, Allentown, Pennsylvania, United States

🇺🇸

Hassman Research Institute /ID# 237501, Berlin, New Jersey, United States

🇺🇸

Psych Atlanta /ID# 235835, Marietta, Georgia, United States

and more 122 locations

The Objective of This Study is to Evaluate the Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD) Who Have Had an Inadequate Response to Antidepressants Alone

First Posted Date
2018-11-13
Last Posted Date
2022-09-21
Lead Sponsor
AbbVie
Target Recruit Count
752
Registration Number
NCT03739203
Locations
🇺🇸

Global Clinical Trials /ID# 235059, Costa Mesa, California, United States

🇺🇸

Institute for Advanced Medical Research /ID# 234992, Atlanta, Georgia, United States

🇺🇸

International Research Associates, LLC /ID# 237410, Miami, Florida, United States

and more 109 locations

Clinical Trial Evaluating the Efficacy, Safety, and Tolerability of Cariprazine in a Dose-Reduction Paradigm in the Prevention of Relapse in Participants With Schizophrenia

Phase 3
Terminated
Conditions
Interventions
First Posted Date
2018-07-20
Last Posted Date
2022-04-11
Lead Sponsor
AbbVie
Target Recruit Count
587
Registration Number
NCT03593213
Locations
🇺🇸

Advanced Research Center, Inc., Anaheim, California, United States

🇺🇸

California Pharmaceutical Research Institute, Inc., Costa Mesa, California, United States

🇺🇸

Collaborative Neuroscience Research, LLC, Torrance, California, United States

and more 92 locations

A Cariprazine Study in the Prevention of Relapse in Bipolar I Disorder Patients Whose Current Episode is Manic or Depressive, With or Without Mixed Features

First Posted Date
2018-06-29
Last Posted Date
2023-09-28
Lead Sponsor
AbbVie
Target Recruit Count
901
Registration Number
NCT03573297
Locations
🇺🇸

Synexus Clinical Research, Inc /ID# 232950, Atlanta, Georgia, United States

🇺🇸

Atlanta Center for Medical Research /ID# 232832, Atlanta, Georgia, United States

🇺🇸

NRC Research Institute /ID# 232741, Orange, California, United States

and more 105 locations

Study on the Efficacy, Safety, and Tolerability of Cariprazine Relative to Placebo in Participants With Bipolar I Depression

Phase 3
Completed
Conditions
Interventions
First Posted Date
2016-02-01
Last Posted Date
2019-01-30
Lead Sponsor
Forest Laboratories
Target Recruit Count
488
Registration Number
NCT02670551
Locations
🇺🇸

Carman Research, Smyrna, Georgia, United States

🇺🇸

Neuroscience Research Institute Inc., Winfield, Illinois, United States

🇺🇸

Midwest Clinical Research Center, Dayton, Ohio, United States

and more 71 locations

Study of the Efficacy of a Fixed-dose Regimen of Cariprazine Compared to Placebo for Treatment of the Depressive Episode in Participants With Bipolar I Disorder

Phase 3
Completed
Conditions
Interventions
First Posted Date
2016-02-01
Last Posted Date
2019-03-12
Lead Sponsor
Forest Laboratories
Target Recruit Count
493
Registration Number
NCT02670538
Locations
🇺🇸

Atlanta Center for Medical Research, Atlanta, Georgia, United States

🇧🇬

Mental Health Centre 'Prof. Dr. Ivan Temkov', EOOD, Burgas, Bulgaria

🇭🇷

Polyclinic Neuron, Zagreb, Croatia

and more 85 locations

Long-term Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy in Patients With Major Depressive Disorder

First Posted Date
2013-04-24
Last Posted Date
2019-08-21
Lead Sponsor
Forest Laboratories
Target Recruit Count
442
Registration Number
NCT01838876
Locations
🇺🇸

Forest Investigative Site 049, Gaithersburg, Maryland, United States

🇺🇸

Forest Investigative Site 077, Rockville, Maryland, United States

🇵🇷

Forest Investigative Site 033, San Juan, Puerto Rico

and more 87 locations

Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD)

First Posted Date
2012-10-29
Last Posted Date
2019-08-28
Lead Sponsor
Forest Laboratories
Target Recruit Count
1022
Registration Number
NCT01715805
Locations
🇺🇸

Forest Investigative Site 067, Bismarck, North Dakota, United States

🇺🇸

Forest Investigative Site 018, Little Rock, Arkansas, United States

🇺🇸

Forest Investigative Site 080, Redlands, California, United States

and more 82 locations
© Copyright 2024. All Rights Reserved by MedPath