Linifanib

Overview

Linifanib (ABT-869) is a small molecule vascular endothelial growth factor (VEGF) receptor-based kinase inhibitor that is designed to suppress tumor growth by preventing the formation of new blood vessels that supply the tumor with oxygen and nutrients and by inhibiting key angiogenic signaling pathways. Linifanib is intended for the treatment of hematologic malignancies and the solid tumors.

Background

Indication

Investigated for use/treatment in leukemia (myeloid), myelodysplastic syndrome, and solid tumors.

Associated Conditions

No associated conditions information available.

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
A Study Evaluating the Bioavailability of Two Formulations of Linifanib and Food Effect on Pharmacokinetics of Linifanib in Subjects With Advanced or Metastatic Solid Tumors	2012/01/10	NCT01506934	Phase 1	Terminated	Abbott
An Extension Study of Linifanib (ABT-869) in Subjects With Advanced or Metastatic Solid Tumors	2011/08/10	NCT01413893	Phase 1	Completed	AbbVie
Effect of Rifampin on the Pharmacokinetics of Linifanib in Subjects With Advanced or Metastatic Solid Tumors	2011/07/26	NCT01401933	Phase 1	Completed	Abbott
To Compare Relative Bioavailability of Two Clinical Formulations of Linifanib.	2011/06/27	NCT01381341	Phase 1	Completed	Abbott
Linifanib in Treating Patients With Advanced, Refractory Colorectal Cancer	2011/06/03	NCT01365910	Phase 2	Terminated	Vanderbilt-Ingram Cancer Center
A Pharmacokinetic Study to Access How the Body Absorbs and Removes Linifanib in Male Patients With Advanced Solid Tumors.	2011/02/01	NCT01286974	Phase 1	Terminated	Abbott
A Study of Linifanib (ABT-869) in Combination With Carboplatin/Paclitaxel in Japanese Subjects With Non-Small Cell Lung Cancer (NSCLC)	2010/10/21	NCT01225302	Phase 1	Completed	AbbVie
WALTZ - Wet Age-Related Macular Degeneration (AMD) AL-39324 Treatment Examination	2009/10/09	NCT00992563	Phase 2	Completed	Alcon Research

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
No FDA approvals found for this drug.

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
No HSA approvals found for this drug.

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
No PPB approvals found for this drug.

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
No TGA approvals found for this drug.

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