Sapacitabine

Generic Name
Sapacitabine
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C26H42N4O5
CAS Number
151823-14-2
Unique Ingredient Identifier
W335P73C3L
Indication

Investigated for use/treatment in solid tumors, cutaneous t-cell lymphoma, myelodysplastic syndrome, and leukemia (lymphoid).

Associated Conditions
-
Associated Therapies
-

Olaparib + Sapacitabine in BRCA Mutant Breast Cancer

Phase 1
Active, not recruiting
Conditions
Interventions
First Posted Date
2018-08-22
Last Posted Date
2024-03-18
Lead Sponsor
Dana-Farber Cancer Institute
Target Recruit Count
10
Registration Number
NCT03641755
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Broad Institute of MIT, Cambridge, Massachusetts, United States

๐Ÿ‡บ๐Ÿ‡ธ

Dana Farber Cancer Institute, Boston, Massachusetts, United States

A Study of Oral Sapacitabine in Elderly Patients With Newly Diagnosed Acute Myeloid Leukemia

Phase 3
Completed
Conditions
Interventions
First Posted Date
2011-02-25
Last Posted Date
2022-06-22
Lead Sponsor
Cyclacel Pharmaceuticals, Inc.
Target Recruit Count
482
Registration Number
NCT01303796
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Rush University Medical Center, Chicago, Illinois, United States

๐Ÿ‡บ๐Ÿ‡ธ

The University of Chicago Medical Center, Chicago, Illinois, United States

๐Ÿ‡บ๐Ÿ‡ธ

St. Francis Medical Group Oncology and Hematology Specialists, Indianapolis, Indiana, United States

and more 114 locations

Sapacitabine, Cyclophosphamide, Rituximab for Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma (CLL/SLL) With Deletion (11q22-23)

First Posted Date
2010-12-03
Last Posted Date
2019-09-06
Lead Sponsor
M.D. Anderson Cancer Center
Target Recruit Count
18
Registration Number
NCT01253460
Locations
๐Ÿ‡บ๐Ÿ‡ธ

University of Texas MD Anderson Cancer Center, Houston, Texas, United States

A Study of Oral Sapacitabine in Patients With Previously Treated Non-Small Cell Lung Cancer

Phase 2
Terminated
Conditions
Interventions
First Posted Date
2009-04-22
Last Posted Date
2021-12-22
Lead Sponsor
Cyclacel Pharmaceuticals, Inc.
Target Recruit Count
62
Registration Number
NCT00885963
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Rush University Medical Center, Chicago, Illinois, United States

๐Ÿ‡บ๐Ÿ‡ธ

Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States

A Randomized Phase II Study of Oral Sapacitabine in Patients With Advanced Cutaneous T-cell Lymphoma

Phase 2
Terminated
Conditions
Interventions
First Posted Date
2007-05-22
Last Posted Date
2021-12-22
Lead Sponsor
Cyclacel Pharmaceuticals, Inc.
Target Recruit Count
16
Registration Number
NCT00476554
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Stanford University Hospitals and Clinics, Stanford, California, United States

๐Ÿ‡บ๐Ÿ‡ธ

Timothy Kuzel, M.D., Chicago, Illinois, United States

๐Ÿ‡บ๐Ÿ‡ธ

The University of Texas MD Anderson Cancer Center, Houston, Texas, United States

Safety and Pharmacology Study of Sapacitabine to Treat Advanced Leukemias or Myelodysplastic Syndromes

Phase 1
Completed
Conditions
Interventions
First Posted Date
2006-09-26
Last Posted Date
2021-12-13
Lead Sponsor
Cyclacel Pharmaceuticals, Inc.
Target Recruit Count
47
Registration Number
NCT00380653
Locations
๐Ÿ‡บ๐Ÿ‡ธ

The University of Texas MD Anderson Cancer Center, Houston, Texas, United States

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