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Cyclacel Pharmaceuticals

Cyclacel Pharmaceuticals logo
🇺🇸United States
Ownership
Public
Established
1996-01-01
Employees
12
Market Cap
-
Website
http://www.cyclacel.com
Introduction

Cyclacel Pharmaceuticals, Inc. is a clinical stage biopharmaceutical company, which engages in the provision of cell cycle, transcriptional regulation and DNA damage response biology to develop medicines for cancer and other proliferative diseases. It operates through the United States and United Kingdom geographical segments. The company builds a biopharmaceutical business, which is focused on hematology and oncology based on a pipeline of novel drug candidates. Its products include CYC065, seliciclib, and sapacitabine. The company was founded by Ronald J. Berenson, David Philip Lane, and David Glover on August 13, 1996 and is headquartered in Berkeley Heights, NJ.

Clinical Trials

18

Active:2
Completed:7

Trial Phases

4 Phases

Early Phase 1:1
Phase 1:12
Phase 2:4
+1 more phases

Drug Approvals

0

Drug Approvals

No drug approvals found

This company may not have drug approvals in our database

Clinical Trials

Distribution across different clinical trial phases (18 trials with phase data)• Click on a phase to view related trials

Phase 1
12 (66.7%)
Phase 2
4 (22.2%)
Early Phase 1
1 (5.6%)
Phase 3
1 (5.6%)

Absorption, Metabolism, and Excretion of CYC065 in Healthy Male Subjects

Early Phase 1
Active, not recruiting
Conditions
Healthy
Interventions
First Posted Date
2023-04-18
Last Posted Date
2024-02-07
Lead Sponsor
Cyclacel Pharmaceuticals, Inc.
Target Recruit Count
8
Registration Number
NCT05817890
Locations
🇺🇸

Labcorp Clinical Research Unit, Madison, Wisconsin, United States

A Study to Investigate CYC140, in Subjects With Advanced Solid Tumors and Lymphoma

Phase 1
Recruiting
Conditions
Solid Tumor, Adult Lymphoma
Interventions
First Posted Date
2022-05-03
Last Posted Date
2024-02-07
Lead Sponsor
Cyclacel Pharmaceuticals, Inc.
Target Recruit Count
330
Registration Number
NCT05358379
Locations
🇺🇸

City of Hope, Duarte, California, United States

🇺🇸

UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, United States

🇺🇸

MD Anderson Cancer Center, Houston, Texas, United States

and more 2 locations

A Study to Investigate Fadraciclib (CYC065), in Subjects With Leukemia or Myelodysplastic Syndrome (MDS)

Phase 1
Suspended
Conditions
Myelodysplastic Syndrome(MDS)
Leukemia
Interventions
First Posted Date
2021-12-23
Last Posted Date
2024-02-08
Lead Sponsor
Cyclacel Pharmaceuticals, Inc.
Target Recruit Count
210
Registration Number
NCT05168904
Locations
🇺🇸

City of Hope, Duarte, California, United States

🇺🇸

MD Anderson Cancer Center, Houston, Texas, United States

A Study to Investigate Fadraciclib (CYC065), in Subjects With Advanced Solid Tumors and Lymphoma

Phase 1
Recruiting
Conditions
Solid Tumor, Adult
Lymphoma
Interventions
First Posted Date
2021-07-30
Last Posted Date
2024-01-25
Lead Sponsor
Cyclacel Pharmaceuticals, Inc.
Target Recruit Count
330
Registration Number
NCT04983810
Locations
🇺🇸

City of Hope, Duarte, California, United States

🇺🇸

MD Anderson Cancer Center, Houston, Texas, United States

🇰🇷

Seoul National University Hospital, Seoul, Korea, Republic of

and more 1 locations

CYC065 CDK Inhibitor and Venetoclax Study in Relapsed/Refractory AML or MDS

Phase 1
Completed
Conditions
AML
MDS
Interventions
First Posted Date
2019-07-12
Last Posted Date
2024-01-25
Lead Sponsor
Cyclacel Pharmaceuticals, Inc.
Target Recruit Count
14
Registration Number
NCT04017546
Locations
🇺🇸

MD Anderson Cancer Center, Houston, Texas, United States

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News

Cyclacel's Plogosertib Shows Promise Against Biliary Tract Cancer in Preclinical Study

Independent researchers found that biliary tract cancer cell lines demonstrated sensitivity to plogosertib, a PLK1 inhibitor, both as monotherapy and in combination treatments.

Cyclacel Completes Enrollment in Fadraciclib Trial for Tumors with CDKN2A/B Abnormalities

Cyclacel Pharmaceuticals completed enrollment in Cohort 8 of its Phase 2 trial of fadraciclib, a CDK2/9 inhibitor, focusing on patients with advanced solid tumors and lymphoma exhibiting CDKN2A/B abnormalities.

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