Sodium sulfide

Generic Name
Sodium sulfide
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
Na2S
CAS Number
1313-82-2
Unique Ingredient Identifier
YGR27ZW0Y7
Background

Sodium sulfide is a chemical compound with a chemical formula Na2S. Sodium sulfide is used in the pulp and paper industry, water treatment, textile industry, and various chemical manufacturing processes including the production of rubber chemicals, sulfur dyes and oil recovery. Along with its hydrate form, sodium sulfide releases hydrogen sulfide (H2S) when in contact with moist air. H2S is an endogenous gaseous transmitter that exhibits anti-inflammatory and antiapoptotic properties. Along with other sulfides, the anti-inflammatory and tissue-protective effects of sodium sulfide have been investigated in models of inflammation and oxidative stress. Interestingly, sodium sulfide was shown to have some cardioprotective role against cardiac ischemia or reperfusion injury, as well as protect lungs against ventilator-induced lung injury . However the clinical significance and mechanism of action of sodium sulfide and replication of results across other studies are not yet fully determined.

Associated Conditions
-
Associated Therapies
-

Pharmacokinetic Assessment of Sodium Sulfide in Subjects With Impaired Renal Function

Phase 1
Terminated
Conditions
Interventions
First Posted Date
2009-04-10
Last Posted Date
2019-12-17
Lead Sponsor
Mallinckrodt
Target Recruit Count
28
Registration Number
NCT00879645
Locations
🇺🇸

DaVita Clinical Research, Minneapolis, Minnesota, United States

© Copyright 2024. All Rights Reserved by MedPath