Peppermint oil

Generic Name
Peppermint oil
Brand Names
-
Drug Type
Biotech
Chemical Formula
-
CAS Number
8006-90-4
Unique Ingredient Identifier
AV092KU4JH
Background

Extracted from the stem, leaves, and flowers of Mentha piperita L. plant, peppermint oil (Mentha piperita) is a popular essential oil used in aromatherapy for both external and internal use. Mentha piperita is a hybrid of spearmint (Mentha spicata) and water mint (Mentha aquatica) . Medicinal use of herbal ingredients such as peppermint oil has a long history of treating digestive disorders and upper respiratory symptoms and cough . There are various over-the-counter and commercial uses of peppermint oil due to its carminative, cholagogue, antibacterial, secretolytic, and choleretic actions . Peppermint oil contains pulegone, which is a naturally-occurring pesticide . Other active constituents of peppermint oil include Menthol, menthone, cineol, and several other volatile oils .

Peppermint oil is used as a flavouring agent in foods and fragrance in hygienic or cosmetic products, and as an anti-itch and cooling agent in topical pharmaceutical products. It is also an active ingredient in topical analgesics for the relief of joint and muscle pain. Peppermint oil can be applied topically to temporarily relieve tension-type headache. The use of peppermint oil in the management of irritable bowel syndrome (IBS) has been investigated in many clinical studies due to its relaxing effects on smooth muscle; however the evidence supporting this use is unclear. Due to its effectiveness in relaxing GI smooth muscle but ability to induce gastroesophageal reflux, enteric-coated formulations of peppermint oil has been established which bypass the upper GI tract unmetabolized, thereby facilitating its effect in the lower GI tract without effects in the upper tract . Peppermint oil is safe and well-tolerated at commonly recommended dosage .

Indication

Indicated for the over-the-counter use for:

-the symptomatic relief of minor spasms of the gastrointestinal tract, flatulence and abdominal pain, especially in patients with irritable bowel syndrome.

-the temporary relief of itching associated with insect bites, eczema, minor burn, sunburn, minor skin irritations, minor cuts, scrapes, atopic dermatitis and other skin disorders.

-the temporary symptomatic relief of mild joint and muscle pain as a local topical analgesic.

-the temporary relief of tension-type headache.

Associated Conditions
Colic, Cough, Flatulence, Hypertonicity of the small intestine, Irritable Bowel Syndrome (IBS), Mild pain, Myalgia, Nasal Congestion, Gas pain
Associated Therapies
-

Use of Aromatherapy in Conjunction With Physical/Occupational Therapy in an Acute Care Setting

First Posted Date
2022-03-16
Last Posted Date
2024-07-03
Lead Sponsor
The University of Texas Health Science Center at San Antonio
Target Recruit Count
200
Registration Number
NCT05282706
Locations
🇺🇸

Bianca Gonzales, San Antonio, Texas, United States

Peppermint Oil for the Treatment of Interstitial Cystitis / Bladder Pain Syndrome

Phase 1
Recruiting
Conditions
Interventions
First Posted Date
2021-04-14
Last Posted Date
2022-08-22
Lead Sponsor
University of Louisville
Target Recruit Count
100
Registration Number
NCT04845217
Locations
🇺🇸

Springs Medical Center, Louisville, Kentucky, United States

Peppermint Oil Pharmacokinetics/Dynamics

Phase 1
Withdrawn
Conditions
Interventions
First Posted Date
2020-08-04
Last Posted Date
2023-12-11
Lead Sponsor
Baylor College of Medicine
Registration Number
NCT04497870
Locations
🇺🇸

Children's Nutrition Research Center, Houston, Texas, United States

Peppermint Oil Pharmacokinetics/Dynamics and Novel Biological Signatures in Children With Functional Abdominal Pain

Phase 1
Completed
Conditions
Interventions
First Posted Date
2017-09-28
Last Posted Date
2022-04-06
Lead Sponsor
Robert Shulman, M.D.
Target Recruit Count
30
Registration Number
NCT03295747
Locations
🇺🇸

Texas Children's Hospital, Houston, Texas, United States

L-Menthol Injection as a Novel Technique During Colonoscopy

Phase 3
Terminated
Conditions
Interventions
First Posted Date
2015-10-27
Last Posted Date
2022-04-19
Lead Sponsor
University Hospitals Cleveland Medical Center
Target Recruit Count
82
Registration Number
NCT02588248
Locations
🇺🇸

University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States

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