Overview
Sennosides (also known as senna glycoside or senna) is a medication used to treat constipation and empty the large intestine before surgery. The medication is taken by mouth or via the rectum. It typically begins working in minutes when given by rectum and within twelve hours when given by mouth. It is a weaker laxative than bisacodyl or castor oil. Sennoside A, one of the sennosides present in the laxative medication, has recently proven effective in inhibiting the ribonuclease H (RNase H) activity of human immunodeficiency virus (HIV) reverse transcriptase .
Background
Sennosides (also known as senna glycoside or senna) is a medication used to treat constipation and empty the large intestine before surgery. The medication is taken by mouth or via the rectum. It typically begins working in minutes when given by rectum and within twelve hours when given by mouth. It is a weaker laxative than bisacodyl or castor oil. Sennoside A, one of the sennosides present in the laxative medication, has recently proven effective in inhibiting the ribonuclease H (RNase H) activity of human immunodeficiency virus (HIV) reverse transcriptase .
Indication
For the over the counter treatment of constipation.
Associated Conditions
- Autointoxication
- Constipation
- Haemorrhoids
- Meteorism
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2018/04/09 | Phase 3 | Completed | |||
2018/03/23 | Phase 3 | Terminated | |||
2015/12/01 | Not Applicable | Completed | |||
2012/02/10 | Phase 4 | Completed | Medical University of Warsaw | ||
2009/05/14 | Not Applicable | Completed |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Geri-Care Pharmaceutical Corp | 57896-458 | ORAL | 8.6 mg in 1 1 | 3/24/2025 | |
| Bryant Ranch Prepack | 71335-1181 | ORAL | 8.6 mg in 1 1 | 4/29/2025 | |
| PAI Holdings, LLC dba PAI Pharma | 0121-4967 | ORAL | 8.8 mg in 5 mL | 4/28/2025 | |
| Atlantis Consumer Healthcare, Inc. | 67618-110 | ORAL | 8.6 mg in 1 1 | 4/17/2025 | |
| ATLANTIC BIOLOGICALS CORP. | 17856-1127 | ORAL | 417.12 mg in 237 mL | 5/23/2025 | |
| Walgreens | 0363-8750 | ORAL | 8.6 mg in 1 1 | 5/7/2025 | |
| Meijer, Inc. | 79481-0555 | ORAL | 8.6 mg in 1 1 | 3/24/2025 | |
| Cardinal Health | 70000-0519 | ORAL | 8.6 mg in 1 1 | 3/26/2025 | |
| Safecor Health, LLC | 48433-222 | ORAL | 8.8 mg in 5 mL | 6/7/2025 | |
| Geri-Care Pharmaceutical Corp | 57896-454 | ORAL | 8.6 mg in 1 1 | 5/15/2025 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| SENNA TABLET 7.5 mg | SIN02550P | TABLET | 7.5 mg | 4/19/1989 | |
| SENOKOT TABLET 7.5 mg | SIN04731P | TABLET | 7.5 mg | 6/25/1990 |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| EASUWEI SENNOSIDES TABLETS 20MG | N/A | N/A | N/A | 11/4/2024 | |
| SENCOLAX TAB 7.5MG | N/A | hysan pharmaceutical co ltd | N/A | N/A | 7/9/2010 |
| NEPURGO SENNOSIDES TABLETS 20MG | N/A | N/A | N/A | 11/4/2024 | |
| EFORMAT SENNOSIDES TABLETS 20MG | N/A | N/A | N/A | 11/4/2024 |
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| LAXETTES SENNA LAXATIVE TABLETS blister pack | 12817 | Medicine | A | 8/22/1991 | |
| COLAXSEN film coated tablets bottle | 218552 | Medicine | A | 12/13/2013 | |
| APOHEALTH Laxative with Softener sennosides (as sennoside B) 8mg and docusate sodium 50mg film coated tablet bottle | 229304 | Medicine | A | 10/14/2014 | |
| CHEMISTS' OWN NATURAL LAXATIVE WITH SOFTENER tablet blister pack | 90442 | Medicine | A | 8/12/2002 | |
| AdMed Docu/Senna tablets bottle | 372287 | Medicine | A | 8/5/2021 | |
| SOLAX WITH SENNA tablet bottle | 456395 | Medicine | A | 7/25/2024 | |
| Coloxyl with senna tablets - HK | 337361 | Medicine | A | 6/2/2020 | |
| TERRYWHITE CHEMMART SENNALAX film coated tablet bottle | 309394 | Medicine | A | 9/18/2018 | |
| AMCAL SENNA-COL film coated tablet bottle (new formulation) | 231508 | Medicine | A | 12/5/2014 | |
| PHARMACY CHOICE SENNALAX film coated tablet bottle | 176296 | Medicine | A | 9/30/2010 |