Aramchol

Generic Name
Aramchol
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C44H79NO5
CAS Number
246529-22-6
Unique Ingredient Identifier
QE1Q24M65Y
Background

Aramchol has been used in trials studying the treatment of HIV, Gallstones, Fatty Liver, Metabolic Syndrome, and Nonalcoholic Steatohepatitis, among others.

Associated Conditions
-
Associated Therapies
-
Clinical Trials
Related News

An Open-Label, Two-Part Study Designed to Assess the Absolute Bioavailability and Mass Balance of Aramchol

Phase 1
Completed
Conditions
NASH
Interventions
Drug: Aramchol
First Posted Date
2023-05-24
Last Posted Date
2023-05-24
Lead Sponsor
Galmed Pharmaceuticals Ltd
Target Recruit Count
6
Registration Number
NCT05874336
Locations
🇬🇧

Quotient Sciences, Mere Way, Ruddington Fields, Ruddington, Nottingham, NG11 6JS, UK., Nottingham, United Kingdom

Comparison of Aramchol Concentrations With Once or Twice Daily Dosing

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: Aramchol
First Posted Date
2018-12-12
Last Posted Date
2019-08-09
Lead Sponsor
Galmed Pharmaceuticals Ltd
Target Recruit Count
16
Registration Number
NCT03774173
Locations
🇬🇧

Hammersmith Medicines Research (HMR), London, United Kingdom

Study of Potential for Drug Interactions Mediated by CYP3A4 Inhibition With Aramchol in Healthy Volunteers

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: Aramchol
Drug: Midazolam
Drug: Atorvastatin
First Posted Date
2018-11-30
Last Posted Date
2019-08-22
Lead Sponsor
Galmed Pharmaceuticals Ltd
Target Recruit Count
15
Registration Number
NCT03760848
Locations
🇬🇧

Hammersmith Medicines Research (HMR), London, United Kingdom

Pharmacokinetics of Single and Multiple Escalating Doses of Aramchol Administered Under Fed Conditions in Healthy Chinese Volunteers

Phase 1
Completed
Conditions
Healthy Volunteers
Interventions
Drug: Aramchol
Drug: Placebo
First Posted Date
2016-06-17
Last Posted Date
2016-12-21
Lead Sponsor
Galmed Pharmaceuticals Ltd
Target Recruit Count
64
Registration Number
NCT02803996
Locations
🇺🇸

WCCT Global, LLC., Cypress, California, United States

Aramchol for HIV-associated Nonalcoholic Fatty Liver Disease and Lipodystrophy

First Posted Date
2016-02-18
Last Posted Date
2020-07-17
Lead Sponsor
University of California, San Diego
Target Recruit Count
50
Registration Number
NCT02684591
Locations
🇺🇸

University of California, San Diego, San Diego, California, United States

Pharmacokinetics of Single and Multiple Escalating Doses of Aramchol and Food Effect in Healthy Volunteers

Phase 1
Completed
Conditions
Healthy Volunteers
Interventions
Drug: Aramchol
Drug: Placebo
First Posted Date
2015-02-27
Last Posted Date
2015-02-27
Lead Sponsor
Galmed Pharmaceuticals Ltd
Target Recruit Count
66
Registration Number
NCT02374437

Medical Dissolution of Cholesterol Gallstones Using Oral Aramchol - A Proof of Concept Phase IIa Study

Phase 2
Terminated
Conditions
Gallstones
Interventions
Drug: Placebo
Drug: Aramchol
Device: Ultrasound
First Posted Date
2014-12-25
Last Posted Date
2015-10-05
Lead Sponsor
Galmed Pharmaceuticals Ltd
Target Recruit Count
10
Registration Number
NCT02325492
Locations
🇮🇱

Assuta Medical Center, Tel Aviv, Israel

A Clinical Trial to Evaluate the Efficacy and Safety of Two Aramchol Doses Versus Placebo in Patients With NASH

First Posted Date
2014-10-31
Last Posted Date
2021-07-14
Lead Sponsor
Galmed Research and Development, Ltd.
Target Recruit Count
247
Registration Number
NCT02279524
Locations
🇨🇱

Biomedica Research Group, Santiago, Chile

🇨🇱

Centro de Investigaciones Clinicas Vina del Mar, Vina del Mar, Chile

🇨🇱

Centro de Investigacion Clinica CEIC, Santiago, Chile

and more 74 locations

Study of Aramchol in Patients With Fatty Liver Disease or Nonalcoholic Steatohepatitis

First Posted Date
2010-03-26
Last Posted Date
2012-01-31
Lead Sponsor
Galmed Medical Reserch
Target Recruit Count
60
Registration Number
NCT01094158
Locations
🇮🇱

The Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

🇮🇱

Hillel Yaffe Medical Center, Hadera, Israel

🇮🇱

Rambam, Haifa, Israel

and more 8 locations

A Phase 1 Single and Multiple-Dose Study of Aramchol in Healthy Male Volunteers

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: Aramchol
First Posted Date
2008-10-21
Last Posted Date
2010-11-03
Lead Sponsor
Galmed Medical Reserch
Target Recruit Count
41
Registration Number
NCT00776841
Locations
🇮🇱

Tasmc Clinical Research Center, Tel-Aviv, Israel

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