Acyline

Generic Name: Acyline

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₈₀H_₁₀₂ClN_₁₅O_₁₄

CAS Number: 170157-13-8

Unique Ingredient Identifier: S3439D3B35

Background: Acyline has been investigated for the prevention and treatment of Hypogonadism and Contraception.

Associated Conditions: -

Associated Therapies: -

Clinical Trials

Cardiovascular Outcomes of Low Testosterone

Not Applicable

Completed

Conditions: Hypogonadism

Interventions: Drug: Acyline
Drug: Placebo Gel
Drug: Placebo Tablet
Drug: Testosterone Gel
Drug: Arimidex

First Posted Date: 2016-05-02

Last Posted Date: 2024-10-10

Lead Sponsor: University of Colorado, Denver

Target Recruit Count: 232

Registration Number: NCT02758431

Locations: 🇺🇸
University of Colorado CCTSI CTRC, Denver, Colorado, United States

ITT-5 Mechanisms of Spermatogenesis in Man

Phase 2

Withdrawn

Conditions: Gonadotropin Deficiency

Interventions: Drug: Testosterone 1% Gel
Drug: Acyline
Drug: HCG
Drug: placebo dutasteride
Drug: Ketoconazole
Drug: Dutasteride
Drug: placebo ketoconazole

First Posted Date: 2014-05-28

Last Posted Date: 2019-12-18

Lead Sponsor: University of Washington

Registration Number: NCT02147964

Locations: 🇺🇸
University of Washington Medical Center (Health Sciences), Seattle, Washington, United States

T-IR- Study to Understand the Effects of Testosterone and Estrogen on the Body's Response to the Hormone Insulin

Phase 1

Completed

Conditions: Insulin Resistance
Type 2 Diabetes Mellitus
Obesity
Androgen Deficiency
Metabolic Disease

Interventions: Drug: Acyline
Drug: Testosterone 1.62% gel
Drug: Placebo gel (for Testosterone 1.62% gel)
Drug: Placebo pill (for Letrozole)
Drug: Letrozole

First Posted Date: 2012-09-18

Last Posted Date: 2018-05-08

Lead Sponsor: University of Washington

Target Recruit Count: 53

Registration Number: NCT01686828

Locations: 🇺🇸
University of Washington, Seattle, Washington, United States

PROS-2 Dose Response Effects of Exogenous Testosterone on the Prostate

Phase 2

Completed

Conditions: Healthy

Interventions: Other: placebo acyline
Drug: Testosterone 1% gel 1.25 g
Drug: Testosterone 1% gel 2.5 g
Drug: Testosterone 1% gel 5.0 g
Drug: testosterone 1% gel 10 g
Drug: testosterone 1% gel 15 g
Other: placebo gel
Drug: Acyline

First Posted Date: 2011-04-01

Last Posted Date: 2017-10-05

Lead Sponsor: University of Washington

Target Recruit Count: 62

Registration Number: NCT01327495

Locations: 🇺🇸
University of Washington, Seattle, Washington, United States

ITT4 Intratesticular Hormonal Milieu in Man (ITT4)

Phase 1

Completed

Conditions: Healthy Males

Interventions: Drug: Acyline
Drug: Testosterone gel
Drug: Placebo ketoconazole
Drug: ketoconazole 400
Drug: Ketoconazole 800
Drug: Dutasteride
Drug: Anastrozole

First Posted Date: 2010-10-06

Last Posted Date: 2014-03-31

Lead Sponsor: University of Washington

Target Recruit Count: 46

Registration Number: NCT01215292

Locations: 🇺🇸
University of Washington, Seattle, Washington, United States

ORAL T-8 Oral Testosterone for Male Hormonal Contraception

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Oral Testosterone
Drug: Acyline

First Posted Date: 2010-07-22

Last Posted Date: 2013-09-06

Lead Sponsor: University of Washington

Target Recruit Count: 14

Registration Number: NCT01167829

Locations: 🇺🇸
University of Washington, Seattle, Washington, United States

HOP-3 Manipulation of the Intratesticular Hormonal Milieu With Exogenous Testosterone

Phase 1

Completed

Conditions: Healthy Males

Interventions: Drug: Acyline
Other: placebo hCG (no active ingredient)
Drug: hCG (human chorionic gonadotropin)
Drug: Testosterone gel

First Posted Date: 2009-02-09

Last Posted Date: 2016-01-11

Lead Sponsor: University of Washington

Target Recruit Count: 59

Registration Number: NCT00839319

Locations: 🇺🇸
University of Washington, Seattle, Washington, United States

CEP-1 Hormonal Regulation of Circulating Endothelial Progenitor Cells and HDL-C in Men

Phase 2

Completed

Conditions: Healthy

Interventions: Drug: Acyline
Drug: Acyline + Testosterone gel
Drug: Acyline + testosterone gel + anastrozole

First Posted Date: 2008-08-08

Last Posted Date: 2012-10-12

Lead Sponsor: University of Washington

Target Recruit Count: 31

Registration Number: NCT00729859

ORAL T-6: Oral Androgens in Man-6

Phase 1

Completed

Conditions: Contraception
Hypogonadism

Interventions: Drug: Acyline
Drug: Testosterone
Drug: Finasteride

First Posted Date: 2008-04-22

Last Posted Date: 2011-01-24

Lead Sponsor: University of Washington

Target Recruit Count: 16

Registration Number: NCT00663793

Locations: 🇺🇸
University of Washington, Seattle, Washington, United States

ACY-7 Oral Administration of Acyline

Phase 1

Completed

Conditions: Healthy

First Posted Date: 2008-01-28

Last Posted Date: 2011-06-09

Lead Sponsor: University of Washington

Target Recruit Count: 4

Registration Number: NCT00603187

Locations: 🇺🇸
University of Washington, Seattle, Washington, United States

Drug Development Updates

Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.

Home Terms & Conditions Privacy Policy