Tesetaxel

Generic Name
Tesetaxel
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C46H60FN3O13
CAS Number
333754-36-2
Unique Ingredient Identifier
UG97LO5M8Y
Background

Tesetaxel has been used in trials studying the treatment of Cancer, Melanoma, Prostate Cancer, Gastric Carcinoma, and Advanced Melanoma, among others.

Associated Conditions
-
Associated Therapies
-

The Effect of Tesetaxel on the QTc Interval and the Effect of Food, Itraconazole, and Rifampin on Tesetaxel Pharmacokinetics in Patients With Advanced Solid Tumors

First Posted Date
2020-03-18
Last Posted Date
2021-07-28
Lead Sponsor
Odonate Therapeutics, Inc.
Target Recruit Count
93
Registration Number
NCT04312282
Locations
🇺🇸

NEXT Oncology, San Antonio, Texas, United States

🇺🇸

Mary Crowley Cancer Research, Dallas, Texas, United States

🇺🇸

START Midwest, Grand Rapids, Michigan, United States

Tesetaxel Plus 3 Different PD-(L)1 Inhibitors in Patients With Triple-Negative MBC and Tesetaxel Monotherapy in Patients With HER2-Negative MBC

First Posted Date
2019-05-16
Last Posted Date
2021-07-30
Lead Sponsor
Odonate Therapeutics, Inc.
Target Recruit Count
294
Registration Number
NCT03952325
Locations
🇺🇸

West Cancer Center, Germantown, Tennessee, United States

🇸🇬

National Cancer Centre Singapore, Singapore, Singapore

🇺🇸

Sarah Cannon Research Institute - Florida Cancer Specialists, Fort Myers, Florida, United States

and more 8 locations

Tesetaxel Plus Reduced Dose of Capecitabine in Patients With HER2 Negative, HR Positive, LA/MBC

Phase 2
Terminated
Conditions
Interventions
First Posted Date
2019-03-01
Last Posted Date
2021-07-30
Lead Sponsor
Odonate Therapeutics, Inc.
Target Recruit Count
152
Registration Number
NCT03858972
Locations
🇺🇸

Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas, Texas, United States

🇰🇷

Asan Medical Center, Seoul, Korea, Republic of

🇨🇦

Hopital Maisonneuve-Rosemont, Montréal, Canada

and more 22 locations

Tesetaxel Every 3 Weeks vs Weekly vs Capecitabine as 1st-line Therapy for Locally Advanced or Metastatic Breast Cancer

First Posted Date
2012-05-31
Last Posted Date
2012-06-01
Lead Sponsor
Genta Incorporated
Target Recruit Count
213
Registration Number
NCT01609127
Locations
🇺🇸

The West Clinic, Memphis, Tennessee, United States

Capecitabine/Tesetaxel Versus Capecitabine/Placebo as Second-line Therapy for Gastric Cancer

First Posted Date
2012-04-09
Last Posted Date
2012-07-24
Lead Sponsor
Genta Incorporated
Target Recruit Count
580
Registration Number
NCT01573468
Locations
🇩🇪

Krankenhaus Nordwest, Frankfurt, Germany

🇺🇸

The University of Texas MD Anderson Cancer Center, Houston, Texas, United States

🇨🇳

National Cheng Kung University Hospital, Tainan, Taiwan

Study of Tesetaxel in Japanese Patients With Solid Tumors

Phase 1
Conditions
Interventions
First Posted Date
2011-04-18
Last Posted Date
2012-03-13
Lead Sponsor
Genta Incorporated
Target Recruit Count
12
Registration Number
NCT01337310
Locations
🇯🇵

Kinki University School of Medicine, Osaka-fu, Japan

Tesetaxel in Chemotherapy-naive Patients With Progressive, Castration-resistant Prostate Cancer

Phase 2
Conditions
Interventions
First Posted Date
2011-02-15
Last Posted Date
2012-07-24
Lead Sponsor
Genta Incorporated
Target Recruit Count
57
Registration Number
NCT01296243
Locations
🇺🇸

Memorial Sloan-Kettering Cancer Center, New York, New York, United States

🇺🇸

The Cancer Institute of New Jersey, New Brunswick, New Jersey, United States

🇺🇸

University of Michigan Health System, Ann Arbor, Michigan, United States

and more 1 locations

Tesetaxel for Previously Treated Patients With Bladder Cancer

First Posted Date
2010-10-07
Last Posted Date
2012-07-11
Lead Sponsor
Genta Incorporated
Target Recruit Count
33
Registration Number
NCT01215877
Locations
🇮🇹

San Camillo Forlanini Hospital, Rome, Italy

🇺🇸

Memorial Sloan-Kettering Cancer Center, New York, New York, United States

🇺🇸

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States

Tesetaxel as Second-line Therapy for Patients With Advanced Gastric Cancer

First Posted Date
2010-03-29
Last Posted Date
2012-03-15
Lead Sponsor
Genta Incorporated
Target Recruit Count
27
Registration Number
NCT01095120
Locations
🇰🇷

Severance Hospital, Yonsei University Health System, Seoul, Korea, Republic of

🇺🇸

Northwestern Medical Faculty Foundation, Chicago, Illinois, United States

🇺🇸

Abramson Cancer of the University of Pennsylvania at Perelman Center for Advanced Medicine, Philadelphia, Pennsylvania, United States

and more 1 locations

Tesetaxel as Second-line Therapy for Patients With Advanced Melanoma and Normal Serum LDH

Phase 2
Conditions
First Posted Date
2010-03-25
Last Posted Date
2011-11-08
Lead Sponsor
Genta Incorporated
Target Recruit Count
27
Registration Number
NCT01092585
Locations
🇺🇸

The University of Texas MD Anderson Cancer Center, Houston, Texas, United States

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