Tradipitant

Generic Name: Tradipitant

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₂₈H_₁₆ClF_₆N_₅O

CAS Number: 622370-35-8

Unique Ingredient Identifier: NY0COC51FI

Background: Tradipitant has been used in trials studying the treatment and prevention of Eczema, Pruritus, Gastroparesis, Chronic Pruritus, and Atopic Dermatitis, among others.

Associated Conditions: -

Associated Therapies: -

Clinical Trials

Motion Delos: An Open Label Safety and Efficacy of Tradipitant in Participants Affected by Motion Sickness

Phase 3

Recruiting

Conditions: Motion Sickness

Interventions: Drug: Tradipitant

First Posted Date: 2023-11-18

Last Posted Date: 2024-03-21

Lead Sponsor: Vanda Pharmaceuticals

Target Recruit Count: 500

Registration Number: NCT06138613

Locations: 🇺🇸
Santa Monica Clinical Trials, Santa Monica, California, United States

Motion Serifos: a Study to Investigate the Efficacy of Tradipitant in Participants Affected by Motion Sickness

Phase 3

Completed

Conditions: Motion Sickness

Interventions: Drug: Tradipitant
Drug: Placebo

First Posted Date: 2023-06-15

Last Posted Date: 2024-11-22

Lead Sponsor: Vanda Pharmaceuticals

Target Recruit Count: 316

Registration Number: NCT05903924

Locations: 🇺🇸
Pacific Research Partners, San Diego, California, United States
🇺🇸
Lumos Clinical Research, San Jose, California, United States
🇺🇸
Santa Monica Clinical Trials, Santa Monica, California, United States

and more 2 locations

Tradipitant for Functional Dyspepsia

Phase 2

Conditions: Functional Dyspepsia

Interventions: Drug: Placebo
Drug: Tradipitant

First Posted Date: 2022-12-16

Last Posted Date: 2024-04-09

Lead Sponsor: Xiao Jing (Iris) Wang

Target Recruit Count: 60

Registration Number: NCT05653310

Locations: 🇺🇸
Mayo Clinic in Minnesota, Rochester, Minnesota, United States

Effects of Tradipitant on Satiation, Gastric Volume, Gastric Accommodation, and Gastric Emptying in Healthy Volunteers

Phase 1

Completed

Conditions: Healthy Volunteer

Interventions: Drug: Placebo
Drug: Tradipitant

First Posted Date: 2021-04-19

Last Posted Date: 2024-04-16

Lead Sponsor: Vanda Pharmaceuticals

Target Recruit Count: 27

Registration Number: NCT04849559

Locations: 🇺🇸
Vanda Investigational Site, Rochester, Minnesota, United States

Single-Patient Expanded Access Protocol for Tradipitant In A Single Patient With Gastroparesis

Conditions: Gastroparesis
Diabetic Gastroparesis

First Posted Date: 2020-07-17

Last Posted Date: 2023-10-04

Lead Sponsor: Vanda Pharmaceuticals

Registration Number: NCT04474990

Locations: 🇺🇸
Vanda Investigational Site, Spokane, Washington, United States

Motion Syros: A Study to Investigate the Efficacy of Tradipitant in Subjects Affected by Motion Sickness

Phase 3

Completed

Conditions: Motion Sickness

Interventions: Drug: Tradipitant
Drug: Placebo

First Posted Date: 2020-03-31

Last Posted Date: 2024-12-11

Lead Sponsor: Vanda Pharmaceuticals

Target Recruit Count: 366

Registration Number: NCT04327661

Locations: 🇺🇸
Gulfcoast Psychiatric Associates, Fort Myers, Florida, United States
🇺🇸
Pacific Research Network, LLC, San Diego, California, United States
🇺🇸
Santa Monica Clinical Trials, Santa Monica, California, United States

and more 4 locations

ODYSSEY: A Study to Investigate the Efficacy of Tradipitant in Treating Severe or Critical COVID-19 Infection

Phase 3

Conditions: Coronavirus Infection

Interventions: Drug: Placebo
Drug: Tradipitant

First Posted Date: 2020-03-30

Last Posted Date: 2020-04-20

Lead Sponsor: Vanda Pharmaceuticals

Target Recruit Count: 300

Registration Number: NCT04326426

Locations: 🇺🇸
Lenox Hill Hospital Northwell Health, New York, New York, United States

Evaluating the Effects of Tradipitant vs. Placebo in Atopic Dermatitis (EPIONE2)

Phase 3

Terminated

Conditions: Atopic Dermatitis

Interventions: Drug: Placebo
Drug: Tradipitant

First Posted Date: 2019-10-28

Last Posted Date: 2024-05-14

Lead Sponsor: Vanda Pharmaceuticals

Target Recruit Count: 87

Registration Number: NCT04140695

Locations: 🇺🇸
Vanda Investigational Site, Spokane, Washington, United States

Evaluating the Safety and Efficacy of Tradipitant vs. Placebo in Idiopathic and Diabetic Gastroparesis

Phase 3

Recruiting

Conditions: Gastroparesis
Idiopathic Gastroparesis
Diabetic Gastroparesis

Interventions: Drug: Placebo
Drug: Open Label Tradipitant
Drug: Tradipitant

First Posted Date: 2019-07-22

Last Posted Date: 2024-03-22

Lead Sponsor: Vanda Pharmaceuticals

Target Recruit Count: 201

Registration Number: NCT04028492

Locations: 🇺🇸
Vanda Investigational Site, Salt Lake City, Utah, United States

Motion Sifnos: A Study to Investigate the Efficacy of Tradipitant in Subjects Affected by Motion Sickness

Phase 2

Completed

Conditions: Motion Sickness

Interventions: Drug: Tradipitant
Drug: Placebo

First Posted Date: 2018-12-11

Last Posted Date: 2020-03-11

Lead Sponsor: Vanda Pharmaceuticals

Target Recruit Count: 150

Registration Number: NCT03772340

Locations: 🇺🇸
Vanda Investigational Site, Santa Monica, California, United States

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