Overview
Silver (Ag) is a chemical element that belongs in the family of transition metals in the periodic table. It has a high electrical conductivity, thermal conductivity, and reflectivity. Silver exists as a pure elemental form, alloy with other metals, and mineral. Having critical roles in various applications inducing chemical and industrial fields, silver compounds have also been used in the field of medicine for centuries due to their broad-spectrum biological actions. Silver nanoparticles especially have been widely used in industrial, household, and healthcare-related products due to their potent antimicrobial activity. Silver nitrate and Silver sulfadiazine have been used as topical antibacterial agents for the treatment of skin infections, while Silver sulfadiazine has also been valued for topical burn treatment . Silver and its compounds have been used in trials studying the management of dental caries since the 1800s, and they may be found in dental pastes as an active ingredients. However, some drawbacks of dental use of silver compounds include tooth discolouration and pulp irritation .
Background
Silver (Ag) is a chemical element that belongs in the family of transition metals in the periodic table. It has a high electrical conductivity, thermal conductivity, and reflectivity. Silver exists as a pure elemental form, alloy with other metals, and mineral. Having critical roles in various applications inducing chemical and industrial fields, silver compounds have also been used in the field of medicine for centuries due to their broad-spectrum biological actions. Silver nanoparticles especially have been widely used in industrial, household, and healthcare-related products due to their potent antimicrobial activity. Silver nitrate and Silver sulfadiazine have been used as topical antibacterial agents for the treatment of skin infections, while Silver sulfadiazine has also been valued for topical burn treatment . Silver and its compounds have been used in trials studying the management of dental caries since the 1800s, and they may be found in dental pastes as an active ingredients. However, some drawbacks of dental use of silver compounds include tooth discolouration and pulp irritation .
Indication
Indicated for the treatment of acne for topical use or the management of dental caries for dental use.
Associated Conditions
- Acne
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2025/01/29 | Phase 2 | Not yet recruiting | National University of Malaysia | ||
2024/11/21 | Phase 4 | Recruiting | |||
2024/11/08 | Phase 2 | Not yet recruiting | Francesco Egro | ||
2024/04/05 | Phase 2 | Completed | |||
2024/03/18 | Phase 1 | Completed | |||
2024/03/05 | Not Applicable | Completed | |||
2024/02/05 | Phase 2 | Recruiting | |||
2023/12/15 | Not Applicable | Completed | Minia University | ||
2023/08/02 | Early Phase 1 | Active, not recruiting | |||
2023/07/12 | Phase 1 | Active, not recruiting |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Natural Immunogenics Corp.dba SOVEREIGN NATURALS | 52166-020 | TOPICAL | 30 [hp_X] in 1 mL | 5/22/2025 | |
| Natural Immunogenics Corp.dba SOVEREIGN NATURALS | 52166-009 | TOPICAL | 23 mg in 1000 mL | 5/22/2025 | |
| Natural Immunogenics Corp.dba SOVEREIGN NATURALS | 52166-012 | TOPICAL | 23 mg in 1000 mL | 5/22/2025 | |
| Natural Immunogenics Corp.dba SOVEREIGN NATURALS | 52166-011 | TOPICAL | 23 mg in 1000 mL | 5/22/2025 | |
| Natural Immunogenics Corp.dba SOVEREIGN NATURALS | 52166-026 | TOPICAL | 30 [hp_X] in 1 mL | 5/22/2025 | |
| Natural Immunogenics Corp.dba SOVEREIGN NATURALS | 52166-010 | TOPICAL | 23 mg in 1000 mL | 5/22/2025 | |
| Natural Immunogenics Corp.dba SOVEREIGN NATURALS | 52166-025 | TOPICAL | 30 [hp_X] in 1 mL | 5/22/2025 | |
| Natural Immunogenics Corp.dba SOVEREIGN NATURALS | 52166-018 | TOPICAL | 30 [hp_X] in 1 mL | 5/22/2025 | |
| Deseret Biologicals, Inc. | 43742-1312 | ORAL | 12 [hp_X] in 1 mL | 5/27/2025 | |
| Natural Immunogenics Corp.dba SOVEREIGN NATURALS | 52166-001 | TOPICAL | 30 [hp_X] in 1 mL | 5/22/2025 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| SILVER HEALTH - COLLOIDAL SILVER 30 PPM | 336070 | Medicine | A | 5/9/2020 | |
| Silverwell Colloidal Silver Gel. | 318342 | Silver Well Colloidal Silver | Medicine | A | 6/4/2019 |