MedPath

Magnesium

Generic Name
Magnesium
Brand Names
Vitafol-one
Drug Type
Small Molecule
Chemical Formula
H2Mg
CAS Number
7439-95-4
Unique Ingredient Identifier
I38ZP9992A
Background

Magnesium is classified as an alkaline earth metal and has 2 hydration shells. The element can be found in abundance in the hydrosphere and in mineral salts such as dolomite and magnesium carbonate.

Common dietary sources of magnesium include nuts (cashews, peanuts, almonds), beans, bananas, apples, carrots, broccoli, and leafy greens. Magnesium is an important enzyme cofactor and is essential to several metabolic processes. Further, the mineral helps regulate blood pressure and is necessary for RNA, DNA and protein synthesis among several other functions.

Despite the importance of magnesium and its availability via several food sources, an estimated 56 to 68% of adults who live in developed, western countries do not meet the recommended daily intake (RDI) of magnesium. Several factors and common behaviours reduce the availability of magnesium in the diet such as food processing and cooking vegetables (which are normally a rich source of magnesium).

Indication

Healthy levels of magnesium can be achieved through a well balanced diet, but if food sources are insufficient, magnesium supplements can be used to prevent and treat magnesium deficiencies.

In medicine, various magnesium salts may be used in laxative and antacid products. For example, magnesium citrate is available over-the-counter and may be used to manage occasional constipation. Magnesium sulfate may be used on its own or with total parenteral nutrition to treat hypomagnesemia. Magnesium sulfate is also indicated to prevent seizures in pregnant women with pre-eclampsia, and to manage seizures associated with eclampsia.

Associated Conditions
Calcium Deficiency, Magnesium Deficiency, Zinc Deficiency
Associated Therapies
-

BnH-015B Clinical Trial in Moderate Alzheimer's Disease

Phase 1
Recruiting
Conditions
Alzheimer Disease
Interventions
Drug: BnH-015B 160 mg
Drug: BnH-015B 40 mg (MAD)
Drug: BnH-015B 5 mg
Drug: BnH-015B 10 mg
Drug: BnH-015B 20 mg
Drug: BnH-015B 40 mg (Dietary impact)
Drug: BnH-015B 40 mg
Drug: BnH-015B 80 mg (Part II)
Drug: BnH-015B Placebo (Part II)
Drug: BnH-015B 40 mg (Part II)
Drug: BnH-015B 80 mg
Drug: BnH-015B 80 mg (MAD)
First Posted Date
2024-08-02
Last Posted Date
2025-01-07
Lead Sponsor
BnH Research
Target Recruit Count
92
Registration Number
NCT06535308
Locations
🇰🇷

Seoul National University Hospital, Seoul, Jongno-gu, Korea, Republic of

Efficacy of BNC210 in Acute, As-needed Treatment of Anxiety in Social Anxiety Disorder - 1

Phase 3
Recruiting
Conditions
Social Anxiety Disorder
Interventions
Drug: 225 mg BNC210
Drug: Placebo
First Posted Date
2024-07-19
Last Posted Date
2025-01-07
Lead Sponsor
Bionomics Limited
Target Recruit Count
332
Registration Number
NCT06510504
Locations
🇺🇸

AFFIRM-1 Study Site, Austin, Texas, United States

A Clinical Trial to Evaluate the Safety and Immunogenicity of Synthetic DNAs Encoding a Native-like HIV Env Trimer and Interleukin-12 (INO-6160), Alone or in a Prime-boost Regimen With 3M-052-AF + Alum Adjuvanted VRC HIV Env Trimer 4571 in Adult Participants Without HIV

Phase 1
Active, not recruiting
Conditions
HIV-1-infection
Interventions
Biological: INO-6160, 2 mg
Biological: Trimer-4571 / 100 mcg 3M-052-AF (5 mcg) + Alum (500 mcg)
First Posted Date
2023-04-25
Last Posted Date
2024-11-22
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
20
Registration Number
NCT05828095
Locations
🇺🇸

Penn Prevention CRS, Philadelphia, Pennsylvania, United States

🇺🇸

New York Blood Center CRS, New York, New York, United States

🇺🇸

Vanderbuilt Vaccine (VV) CRS, Nashville, Tennessee, United States

A Study to Evaluate the Effects of Cenicriviroc Mesylate on Arterial Inflammation in People Living With HIV

Phase 2
Completed
Conditions
HIV-1-infection
Interventions
Drug: CVC 150 mg
Other: Placebo for CVC 150 mg
Other: Placebo for CVC 300 mg
Drug: CVC 300 mg
First Posted Date
2022-11-30
Last Posted Date
2024-07-03
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
110
Registration Number
NCT05630885
Locations
🇺🇸

Weill Cornell Chelsea CRS (Site # 7804), New York, New York, United States

🇺🇸

Chapel Hill CRS (Site # 3201), Chapel Hill, North Carolina, United States

🇺🇸

Washington University Therapeutics (WT) CRS (Site # 2101), Saint Louis, Missouri, United States

and more 16 locations

Aspirin Versus Metformin in Pregnancies at High Risk of Preterm Preeclampsia: a 3-arm Randomized Controlled Trial

Not Applicable
Recruiting
Conditions
Preeclampsia
Interventions
Drug: 150 mg acetylsalicylic acid
Drug: 75 mg acetylsalicylic acid
Drug: Placebo of acetylsalicylic acid and Metformin
Drug: 1.5g Metformin
First Posted Date
2022-10-14
Last Posted Date
2023-11-08
Lead Sponsor
Chinese University of Hong Kong
Target Recruit Count
3000
Registration Number
NCT05580523
Locations
🇨🇳

The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China

🇨🇳

West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

🇨🇳

Obstetrics and Gynecology Hospital of Fudan University, Shanghai, Shanghai, China

and more 3 locations

A Trial of the Safety, Tolerability, and Pharmacodynamics of CVL-871 in Subjects With Dementia-Related Apathy

Phase 2
Active, not recruiting
Conditions
Apathy in Dementia
Interventions
Drug: CVL-871 1.0 mg
Drug: CVL-871 3.0 mg
Drug: Placebo
First Posted Date
2021-07-12
Last Posted Date
2025-01-08
Lead Sponsor
Cerevel Therapeutics, LLC
Target Recruit Count
75
Registration Number
NCT04958031
Locations
🇺🇸

Scottsdale, Arizona, Scottsdale, Arizona, United States

🇺🇸

Little Rock, Arkansas, Little Rock, Arkansas, United States

🇺🇸

San Diego, California, San Diego, California, United States

and more 16 locations

Woodsmoke Particulate + Prednisone

Phase 1
Completed
Conditions
Airway Inflammation
Interventions
Drug: 60 mg Prednisone
Drug: Placebo
First Posted Date
2019-03-04
Last Posted Date
2024-06-25
Lead Sponsor
University of North Carolina, Chapel Hill
Target Recruit Count
12
Registration Number
NCT03861390
Locations
🇺🇸

Center for Environmental Medicine, Asthma and Lung Biology at UNC Chapel Hill, Chapel Hill, North Carolina, United States

Magnesium Sulfate in Thrombotic Thrombocytopenic Purpura in Intensive Care

Phase 3
Conditions
Thrombotic Thrombocytopenic Purpura
Interventions
Drug: Placebo - Concentrate
Drug: Sulfate, Magnesium
First Posted Date
2017-08-03
Last Posted Date
2021-10-29
Lead Sponsor
Assistance Publique - Hôpitaux de Paris
Target Recruit Count
74
Registration Number
NCT03237819
Locations
🇫🇷

Saint Louis hospital, Paris, France

MAGnesium Adjunction in Alcohol Withdrawal Syndrome: a Multicenter Assessment (MAGMA)

Phase 3
Completed
Conditions
Alcohol Withdrawal Syndrome
Interventions
Drug: Placebo Oral Tablet
Drug: Magnesium
First Posted Date
2017-01-27
Last Posted Date
2021-12-21
Lead Sponsor
Assistance Publique - Hôpitaux de Paris
Target Recruit Count
105
Registration Number
NCT03033823
Locations
🇫🇷

Institut MGEN la Verriere-service SSR addictologie, Le Mesnil saint Denis, Ile-de-France, France

🇫🇷

Hôpital Corentin Celton, AP-HP, Issy-les-Moulineaux, Ile-de-France, France

🇫🇷

Hôpital Louis Mourier, AP-HP, Colombes, Ile-de-France, France

and more 8 locations
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