Methylprednisolone hemisuccinate

Generic Name: Methylprednisolone hemisuccinate

Brand Names: Solu-medrol

Drug Type: Small Molecule

Chemical Formula: C_₂₆H_₃₄O_₈

CAS Number: 2921-57-5

Unique Ingredient Identifier: 5GMR90S4KN

Background: A water-soluble ester of methylprednisolone used for cardiac, allergic, and hypoxic emergencies.

Associated Conditions: Acute Gouty Arthritis, Ankylosing Spondylitis (AS), Berylliosis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatitis bullous, Dermatomyositis (DM), Edema of the cerebrum, Hypercalcemia of Malignancy, Immune Thrombocytopenia (ITP), Leukemias, Lymphoma, Multiple sclerosis exacerbation, Mycosis Fungoides (MF), Ophthalmia, Sympathetic, Pemphigus, Polymyositis, Primary adrenocortical insufficiency, Psoriatic Arthritis, Pure Red Cell Aplasia, Refractory Uveitis, Regional Enteritis, Rheumatoid Arthritis, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Fulminating Pulmonary Tuberculosis, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Severe Allergic Reactions, Symptomatic Sarcoidosis

Associated Therapies: Palliative Treatment

Clinical Trials

Lymphocyte Depletion and Stem Cell Transplantation to Treat Severe Systemic Lupus Erythematosus

Phase 2

Completed

Conditions: Lupus Erythematosus, Systemic

Interventions: Drug: fludarabine phosphate
Drug: cyclophosphamide
Biological: Rituxan (rituximab)
Biological: filgrastim
Drug: methylprednisolone
Other: immunologic technique
Other: laboratory biomarker analysis
Procedure: autologous hematopoietic stem cell transplantation
Drug: Diphenhydramine
Drug: Mesna

First Posted Date: 2004-02-03

Last Posted Date: 2021-01-05

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 9

Registration Number: NCT00076752

Locations: 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States

Methylprednisolone With or Without Doxorubicin in Treating Patients With Metastatic Prostate Cancer

Phase 3

Terminated

Conditions: Prostate Cancer

First Posted Date: 2004-01-27

Last Posted Date: 2016-06-23

Lead Sponsor: UNICANCER

Target Recruit Count: 160

Registration Number: NCT00003682

Locations: 🇫🇷
Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle, Montpellier, France
🇫🇷
Centre Antoine Lacassagne, Nice, France
🇫🇷
Centre de Lute Contre le Cancer,Georges-Francois Leclerc, Dijon, France

and more 12 locations

Pixantrone, Cytarabine, Methylprednisolone, and Cisplatin in Treating Patients With Aggressive Non-Hodgkin's Lymphoma in First Relapse

Phase 2

Conditions: Lymphoma

First Posted Date: 2003-10-07

Last Posted Date: 2009-07-07

Lead Sponsor: Theradex

Registration Number: NCT00069966

Locations: 🇺🇸
Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States
🇺🇸
Baylor University Medical Center, Dallas, Texas, United States
🇺🇸
Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio, United States

and more 26 locations

Ultraviolet-B Light Therapy and Allogeneic Stem Cell Transplantation in Treating Patients With Hematologic Malignancies

Not Applicable

Completed

Conditions: Lymphoma
Myelodysplastic/Myeloproliferative Diseases
Multiple Myeloma and Plasma Cell Neoplasm
Chronic Myeloproliferative Disorders
Leukemia
Myelodysplastic Syndromes

First Posted Date: 2003-09-11

Last Posted Date: 2020-07-27

Lead Sponsor: Case Comprehensive Cancer Center

Target Recruit Count: 10

Registration Number: NCT00068523

Locations: 🇺🇸
Ireland Cancer Center at University Hospitals Case Medical Center, Case Comprehensive Cancer Center, Cleveland, Ohio, United States

Peripheral Stem Cell Transplant in Treating Patients With High-Risk Leukemia

Phase 2

Terminated

Conditions: Chronic Myeloproliferative Disorders
Leukemia
Myelodysplastic/Myeloproliferative Diseases

First Posted Date: 2003-08-07

Last Posted Date: 2013-05-01

Lead Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Target Recruit Count: 51

Registration Number: NCT00066417

Locations: 🇺🇸
NIH - Warren Grant Magnuson Clinical Center, Bethesda, Maryland, United States

Cyclophosphamide, Rituximab, and Either Prednisone or Methylprednisolone in Treating Patients With Lymphoproliferative Disease After Solid Organ Transplantation

Phase 2

Completed

Conditions: Lymphoproliferative Disorder

Interventions: Biological: rituximab
Drug: cyclophosphamide
Drug: methylprednisolone
Drug: prednisone

First Posted Date: 2003-08-07

Last Posted Date: 2019-08-06

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 55

Registration Number: NCT00066469

Locations: 🇺🇸
CCOP - Kalamazoo, Kalamazoo, Michigan, United States
🇺🇸
Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda, California, United States
🇺🇸
Medical City Dallas Hospital, Dallas, Texas, United States

and more 75 locations

Bone Marrow and Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer

Phase 1

Completed

Conditions: Chronic Myeloproliferative Disorders
Graft Versus Host Disease
Leukemia
Lymphoma
Multiple Myeloma and Plasma Cell Neoplasm
Myelodysplastic Syndromes
Precancerous/Nonmalignant Condition

First Posted Date: 2003-05-09

Last Posted Date: 2012-06-01

Lead Sponsor: Northwestern University

Registration Number: NCT00004232

Locations: 🇺🇸
Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States

Treatment of Bone Marrow to Prevent Graft-Versus-Host Disease in Patients With Acute or Chronic Leukemia Undergoing Bone Marrow Transplantation

Phase 2

Completed

Conditions: Leukemia
Graft Versus Host Disease
Myelodysplastic Syndromes

First Posted Date: 2003-05-09

Last Posted Date: 2013-07-10

Lead Sponsor: Chimeric Therapies

Registration Number: NCT00004255

Locations: 🇺🇸
University of Texas - MD Anderson Cancer Center, Houston, Texas, United States
🇺🇸
Shands Hospital and Clinics, University of Florida, Gainesville, Florida, United States
🇺🇸
Presbyterian-St Luke's Medical Center, Denver, Colorado, United States

and more 12 locations