DaxibotulinumtoxinA
- Generic Name
- DaxibotulinumtoxinA
- Brand Names
- Botox, Botox Cosmetic, Daxxify, Dysport, Xeomin
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 93384-43-1
- Unique Ingredient Identifier
- E211KPY694
- Background
DaxibotulinumtoxinA is an acetylcholine release inhibitor and neuromuscular blocking agent. It is a botulinum toxin without accessory proteins purified from the bacterium Clostridium botulinum type A, the gram-positive anaerobic bacterium primarily present in soil. C. botulinum is known to produce toxins that can cause botulism in humans.
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- Indication
DaxibotulinumtoxinA is indicated for the temporary improvement in the appearance of moderate to severe glabellar lines associated with corrugator and/or procerus muscle activity in adult patients. It is also used for the treatment of cervical dystonia in adult patients.
- Associated Conditions
- Cervical Dystonia, Moderate Glabellar Frown Lines (GL), Severe Glabellar Frown Lines (GL)
- Associated Therapies
- -
A Study to Assess BOTOX Injections for the Change of Masseter Muscle Prominence in Adult Participants
- Conditions
- Interventions
- First Posted Date
- 2024-05-06
- Last Posted Date
- 2024-12-05
- Lead Sponsor
- AbbVie
- Target Recruit Count
- 207
- Registration Number
- NCT06399718
- Locations
- ๐บ๐ธ
Westside Aesthetics /ID# 248232, Los Angeles, California, United States
๐บ๐ธPrivate Practice - Dr. Steven G. Yoelin /ID# 268046, Newport Beach, California, United States
๐บ๐ธPacific Clinical Innovations /ID# 248231, Vista, California, United States
A Study to Assess BOTOX Injections in Adult Participants for the Change of Masseter Muscle Prominence
- First Posted Date
- 2024-04-29
- Last Posted Date
- 2024-12-16
- Lead Sponsor
- AbbVie
- Target Recruit Count
- 200
- Registration Number
- NCT06387394
- Locations
- ๐บ๐ธ
Skin Care and Laser Physicians of Beverly Hills /ID# 248223, Los Angeles, California, United States
๐บ๐ธSkin Laser and Surgery Specialists of NY and NJ /ID# 251501, Hackensack, New Jersey, United States
๐บ๐ธDallas Plastic Surgery Institute /ID# 248220, Dallas, Texas, United States
A Study to Evaluate Participant Satisfaction and Natural Outcomes Following Administration of BOTOX Cosmetic Injections in Adult Participants for Treatment of Upper Facial Lines
- First Posted Date
- 2024-01-23
- Last Posted Date
- 2024-04-15
- Lead Sponsor
- AbbVie
- Target Recruit Count
- 100
- Registration Number
- NCT06218251
- Locations
- ๐บ๐ธ
Skin Wellness Dermatology - Homewood /ID# 248469, Birmingham, Alabama, United States
๐บ๐ธThe Research Center at The Maas Clinic /ID# 256633, San Francisco, California, United States
๐บ๐ธPacific Clinical Innovations /ID# 248467, Vista, California, United States
Effects of DaxibotulinumtoxinA for Blepharospasm and Hemifacial Spasm
- Conditions
- Interventions
- First Posted Date
- 2024-01-08
- Last Posted Date
- 2024-12-20
- Lead Sponsor
- Montefiore Medical Center
- Target Recruit Count
- 40
- Registration Number
- NCT06195241
A Study to Assess the Adverse Events and Effectiveness of BOTOX Injections for the Treatment of Moderate to Severe Forehead Lines in Chinese Adult Participants
- First Posted Date
- 2023-12-18
- Last Posted Date
- 2024-04-17
- Lead Sponsor
- AbbVie
- Target Recruit Count
- 140
- Registration Number
- NCT06174688
- Locations
- ๐จ๐ณ
Peking University First Hospital /ID# 249912, Xicheng District, Beijing, China
๐จ๐ณWest China Hospital, Sichuan University /ID# 250474, Chengdu, Sichuan, China
๐จ๐ณBeijing Hospital /ID# 250059, Beijing, Beijing, China
An Open Label, Study of DaxibotulinumtoxinA for Migraine Prevention
- Conditions
- First Posted Date
- 2023-12-01
- Last Posted Date
- 2024-05-10
- Lead Sponsor
- Ki Health Partners. LLC
- Target Recruit Count
- 10
- Registration Number
- NCT06154070
- Locations
- ๐บ๐ธ
The Los Angeles Headache Center, Los Angeles, California, United States
๐บ๐ธNew England Institute For Clinical Research, Stamford, Connecticut, United States
A Study to Assess Adverse Events and Change of Masseter Muscle Prominence Using BOTOX Injections in Adult Participants
- Conditions
- Interventions
- First Posted Date
- 2023-11-18
- Last Posted Date
- 2024-10-18
- Lead Sponsor
- AbbVie
- Target Recruit Count
- 259
- Registration Number
- NCT06137287
- Locations
- ๐ฏ๐ต
Kotoni Tower Skin And Cosmetic Surgery Clinic /ID# 260668, Sapporo, Hokkaido, Japan
๐ฏ๐ตTokai University Hospital /ID# 254204, Isehara, Kanagawa, Japan
๐ฏ๐ตJun Clinic /Id# 254870, Nagano, Fukui, Japan
A Study to Assess the Effectiveness of BOTOX (Botulinum Toxin Type A) Injections for the Change of Masseter Muscle Prominence in Adult Participants
- Conditions
- Interventions
- First Posted Date
- 2023-10-05
- Last Posted Date
- 2024-12-12
- Lead Sponsor
- AbbVie
- Target Recruit Count
- 249
- Registration Number
- NCT06068855
- Locations
- ๐ง๐ช
Da Vinci Clinic /ID# 246731, Beerse, Antwerpen, Belgium
๐ง๐ชEvolve Clinic /ID# 246729, Schilde, Antwerpen, Belgium
๐ง๐ชUniversitair Ziekenhuis Brussel /ID# 246311, Jette, Bruxelles-Capitale, Belgium
Evaluation of BTX Injections in Treatment of Bruxism
- First Posted Date
- 2023-08-08
- Last Posted Date
- 2024-01-05
- Lead Sponsor
- Alexandria University
- Target Recruit Count
- 12
- Registration Number
- NCT05980559
Effect of Botox Injection in Anterior Belly of Digastric on Skeletal Relapse Following Mandibular Advancement Surgery
- First Posted Date
- 2022-10-10
- Last Posted Date
- 2022-10-12
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 10
- Registration Number
- NCT05573581
Drug Development Updates
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