MedPath

Camrelizumab

Generic Name
Camrelizumab
Drug Type
Biotech
CAS Number
1798286-48-2
Unique Ingredient Identifier
73096E137E
Background

Camrelizumab is under investigation in clinical trial NCT03417895 (SHR-1210 Combined With Apatinib in Treatment of ED-SCLC After Failure of First Line Standard Therapy).

Indication

⑴用于至少经过二线系统化疗的复发或难治性经典型霍奇金淋巴瘤患者的治疗。

⑵用于霍奇金淋巴瘤(三线)、肝细胞癌(二线)、非鳞状非小细胞肺癌(一线联合)、食管鳞癌(二线)。

⑶用于既往接受过二线及以上化疗后疾病进展或不可耐受的晚期鼻咽癌患者的治疗。

⑷联合顺铂和吉西他滨用于局部复发或转移性鼻咽癌患者的一线治疗。

Combination Camrelizumab (SHR-1210) and Apatinib for Downstaging/Bridging of HCC Before Liver Transplant

Phase 1
Conditions
Hepatocellular Carcinoma
Liver Transplant
Interventions
First Posted Date
2019-07-29
Last Posted Date
2019-07-29
Lead Sponsor
Zhejiang University
Target Recruit Count
120
Registration Number
NCT04035876
Locations
🇨🇳

The First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou, Zhejiang, China

SHR-1210 Plus Apatinib in Patients With Advanced-Stage Hepatocellular Carcinoma

Phase 2
Conditions
Hepatocellular Carcinoma
Interventions
First Posted Date
2019-07-10
Last Posted Date
2019-07-11
Lead Sponsor
Shanghai Zhongshan Hospital
Target Recruit Count
40
Registration Number
NCT04014101
Locations
🇨🇳

Zhongshan Hospital, Shanghai, Shanghai, China

PD-1 Antibody SHR-1210 Combined With Apatinib of First-line Treatment of Advanced Acral Melanoma

Phase 2
Conditions
Melanoma
Interventions
First Posted Date
2019-05-20
Last Posted Date
2019-05-20
Lead Sponsor
Peking University Cancer Hospital & Institute
Target Recruit Count
30
Registration Number
NCT03955354
Locations
🇨🇳

Guo Jun, Beijing, Beijing, China

🇨🇳

Beijing Cancer Hospital, Beijing, China

SHR-1210 Combined With Trastuzumab , Oxaliplatin and Capecitabine for Neoadjuvant Therapy of Gastric Adenocarcinoma/Gastroesophageal Junction Adenocarcinoma

Phase 2
Active, not recruiting
Conditions
Gastric Cancer
Interventions
First Posted Date
2019-05-15
Last Posted Date
2024-02-28
Lead Sponsor
Henan Cancer Hospital
Target Recruit Count
25
Registration Number
NCT03950271
Locations
🇨🇳

Henan Cancer Hospital, Zhengzhou, Henan, China

A Trial of SHR-1210 (an Anti-PD-1 Inhibitor) in Combination With Apatinib and Fluzoparib in Patients With TNBC

Phase 1
Completed
Conditions
Triple Negative Breast Cancer
Interventions
First Posted Date
2019-05-10
Last Posted Date
2022-08-12
Lead Sponsor
Jiangsu HengRui Medicine Co., Ltd.
Target Recruit Count
32
Registration Number
NCT03945604
Locations
🇨🇳

Beijing Cancer Hosptial, Beijing, Beijing, China

Camrelizumab(SHR-1210) Combined With Apatinib in the Treatment of Advanced Metastatic Colorectal Cancer

Phase 2
Conditions
Metastatic Colorectal Cancer
Interventions
First Posted Date
2019-04-11
Last Posted Date
2019-04-16
Lead Sponsor
Sun Yat-sen University
Target Recruit Count
50
Registration Number
NCT03912857
Locations
🇨🇳

Cancer center of Sun Yat-sen University, Guangzhou, Guangdong, China

Neoadjuvant Immunotherapy for Resectable Gastric Cancer

Phase 2
Completed
Conditions
Gastric Cancer
Interventions
First Posted Date
2019-03-18
Last Posted Date
2024-12-16
Lead Sponsor
Qilu Hospital of Shandong University
Target Recruit Count
25
Registration Number
NCT03878472
Locations
🇨🇳

Qilu hospital of Shandong univertisy, Jinan, Shandong, China

A Study of SHR-1702 Alone or With Camrelizumab in Participants With Advanced Relapsed/Refractory Solid Tumors

Phase 1
Terminated
Conditions
Advanced Solid Tumor
Interventions
First Posted Date
2019-03-12
Last Posted Date
2023-06-05
Lead Sponsor
Jiangsu HengRui Medicine Co., Ltd.
Target Recruit Count
8
Registration Number
NCT03871855
Locations
🇨🇳

Chinese PLA General Hospital, Beijing, Beijing, China

SHR-1210 in Combination With Apatinib in Patients With Metastatic, Persistent, or Recurrent Cervical Cancer

Phase 2
Completed
Conditions
Recurrent Cervical Carcinoma
Metastatic Cervical Cancer
Interventions
First Posted Date
2019-01-25
Last Posted Date
2023-04-11
Lead Sponsor
Sun Yat-sen University
Target Recruit Count
45
Registration Number
NCT03816553
Locations
🇨🇳

Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China

🇨🇳

The First affiliated Hospital of Sun Yat-sen University, Guanzhou, Guangdong, China

🇨🇳

Guangzhou Panyu Central Hospital, Guangzhou, Guangdong, China

A Phase II Study of SHR-1210 vs Placebo as Consolidation Chemotherapy After Radical Concurrent Chemoradiotherapy in Locally Advanced ESCC

Phase 2
Conditions
Esophageal Squamous Cell Carcinoma
Interventions
Drug: Placebo
First Posted Date
2019-01-25
Last Posted Date
2019-01-25
Lead Sponsor
The First Affiliated Hospital of Zhengzhou University
Target Recruit Count
725
Registration Number
NCT03817658
Locations
🇨🇳

The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

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