Losartan
- Generic Name
- Losartan
- Brand Names
- Hyzaar, Cozaar
- Drug Type
- Small Molecule
- Chemical Formula
- C22H23ClN6O
- CAS Number
- 114798-26-4
- Unique Ingredient Identifier
- JMS50MPO89
- Background
Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough similar to placebo or hydrochlorothiazide. Los...
- Indication
Losartan is indicated to treat hypertension in patients older than 6 years, reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy (though this benefit may not extend to patients with African heritage), and to treat diabetic nephropathy with elevated serum creatinine and proteinuria in patients with type 2 diabetes and hyper...
- Associated Conditions
- Diabetic Nephropathy, Ventricular Dysfunction, Hypertension, Marfan Syndrome, Ischemic Stroke
- Associated Therapies
- -
Olmesartan Medoxomil in Hypertension and Renal Impairment
- Conditions
- Interventions
- First Posted Date
- 2005-09-09
- Last Posted Date
- 2010-10-14
- Lead Sponsor
- Sankyo Pharma Gmbh
- Target Recruit Count
- 393
- Registration Number
- NCT00151827
Renin Angiotensin System Study (RASS/B-RASS)
- Conditions
- First Posted Date
- 2005-09-02
- Last Posted Date
- 2008-11-06
- Lead Sponsor
- Michael Mauer, MD
- Target Recruit Count
- 285
- Registration Number
- NCT00143949
- Locations
- 🇨🇦
Mt Sinai Hospital, University of Toronto (Clinical Ctr), Toronto, Ontario, Canada
🇨🇦Montreal Childrens Hospital, McGill University (Clinical Ctr), Montreal, Quebec, Canada
🇨🇦Royal Victoria Hospital, McGill University (Data Center), Montreal, Quebec, Canada
ALLOGRAFT, A Study to Evaluate the Renal Protective Effects of Losartan (0954-222)(COMPLETED)
- First Posted Date
- 2005-09-01
- Last Posted Date
- 2024-08-15
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 367
- Registration Number
- NCT00140907
Long Term Effects of Enalapril and Losartan on Genetic Heart Disease
- Conditions
- First Posted Date
- 1999-11-04
- Last Posted Date
- 2008-03-04
- Target Recruit Count
- 112
- Registration Number
- NCT00001534
- Locations
- 🇺🇸
National Heart, Lung and Blood Institute (NHLBI), Bethesda, Maryland, United States
Study of Inherited Changes of Receptors Located on Blood Vessels
- Conditions
- First Posted Date
- 1999-11-04
- Last Posted Date
- 2008-03-04
- Target Recruit Count
- 200
- Registration Number
- NCT00001741
- Locations
- 🇺🇸
National Heart, Lung and Blood Institute (NHLBI), Bethesda, Maryland, United States
Drug Development Updates
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