Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According t...
For use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous (myeloid, myelocytic, granulocytic) leukemia (FDA has designated busulfan as an orphan drug for this use). It is also used as a component of pretransplant conditioning regimens in patients undergoing...
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States
Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
III Medizinische Klinik Mannheim, Mannheim, Germany
University of Chicago Cancer Research Center, Chicago, Illinois, United States
Rainbow Babies and Children's Hospital, Cleveland, Ohio, United States
West Virginia University Health Sciences Center - Charleston, Charleston, West Virginia, United States
Universitair Ziekenhuis Gent, Ghent, Belgium
Rikshospitalet University Hospital, Oslo, Norway
Birmingham Children's Hospital, Birmingham, England, United Kingdom
Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium, Seattle, Washington, United States
Ireland Cancer Center at University Hosptials Case Medical Center, Case Comprehensive Cancer Center, Cleveland, Ohio, United States
Ireland Cancer Center at University Hospitals Case Medical Center, Case Comprehensive Cancer Center, Cleveland, Ohio, United States
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
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