Metformin
- Generic Name
- Metformin
- Brand Names
- Actoplus Met, Avandamet, Fortamet, Glucophage, Glucovance, Glumetza, Glycon, Invokamet, Janumet, Jentadueto, Kazano, Kombiglyze, Komboglyze, Qternmet, Riomet, Segluromet, Synjardy, Trijardy, Velmetia, Xigduo
- Drug Type
- Small Molecule
- Chemical Formula
- C4H11N5
- CAS Number
- 657-24-9
- Unique Ingredient Identifier
- 9100L32L2N
- Background
Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.
...
- Indication
Metformin immediate-release formulations
Metformin is indicated as an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients ≥10 years old with type 2 diabetes mellitus.
Metformin extended-release tablet (XR)
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- Associated Conditions
- Cardiovascular Mortality, End Stage Renal Disease (ESRD), Hospitalizations, Polycystic Ovarian Syndrome (PCOS), Type 2 Diabetes Mellitus, Decreased estimated glomerular filtration rate
- Associated Therapies
- -
Determine Whether Glycemic Control is Different Between Lantus & a 3rd Oral Agent When Failure With Other Treatment
- Conditions
- First Posted Date
- 2002-10-02
- Last Posted Date
- 2011-01-11
- Lead Sponsor
- Sanofi
- Target Recruit Count
- 240
- Registration Number
- NCT00046462
- Locations
- 🇺🇸
Aventis, Bridgewater, New Jersey, United States
Diabetes Prevention Program Outcomes Study
- Conditions
- Interventions
- First Posted Date
- 2002-06-05
- Last Posted Date
- 2021-12-28
- Target Recruit Count
- 2779
- Registration Number
- NCT00038727
- Locations
- 🇺🇸
George Washington University, Rockville, Maryland, United States
A Research Study to Determine the Safety and Efficacy of Glucovance Compared to Metformin and Glyburide in Children and Adolescents With Type 2 Diabetes.
- Conditions
- First Posted Date
- 2002-05-06
- Last Posted Date
- 2011-04-15
- Lead Sponsor
- Bristol-Myers Squibb
- Registration Number
- NCT00035542
- Locations
- 🇺🇸
National Institute Of Clinical Research, Los Angeles, California, United States
🇺🇸Driscoll Children's Hospital/Division of Medical Education/William Riley, Corpus Christi, Texas, United States
🇺🇸Metro Health Medical Center, Cleveland, Ohio, United States
Glycemic Control and Complications in Diabetes Mellitus Type 2 (VADT)
- Conditions
- Interventions
- First Posted Date
- 2002-03-22
- Last Posted Date
- 2017-03-30
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 1791
- Registration Number
- NCT00032487
- Locations
- 🇺🇸
Southern Arizona VA Health Care System, Tucson, Tucson, Arizona, United States
🇺🇸VA Medical Center, Long Beach, Long Beach, California, United States
🇺🇸Edward Hines, Jr. VA Hospital, Hines, Illinois, United States
Metformin and Rosiglitazone, Alone or in Combination, in HIV-Infected Patients With Insulin and Fat Abnormalities
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2013-07-22
- Target Recruit Count
- 105
- Registration Number
- NCT00015691
- Locations
- 🇺🇸
Johns Hopkins Hosp, Baltimore, Maryland, United States
🇺🇸Ohio State Univ Hosp Clinic, Columbus, Ohio, United States
🇺🇸Vanderbilt Univ Med Ctr, Nashville, Tennessee, United States
A Clinical Trial to Prevent the Complications of Insulin Resistance (Including Type-2 Diabetes)
- Conditions
- First Posted Date
- 2001-04-26
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- National Center for Research Resources (NCRR)
- Target Recruit Count
- 300
- Registration Number
- NCT00015626
- Locations
- 🇺🇸
Cornell University, New York, New York, United States
Metformin to Treat Obesity in Children With Insulin Resistance
- First Posted Date
- 2000-05-22
- Last Posted Date
- 2015-05-08
- Lead Sponsor
- Jack Yanovski, M.D.
- Target Recruit Count
- 100
- Registration Number
- NCT00005669
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
Randomized Study of the Effect of Decreased Hyperinsulinemia on the Ovulatory Response to Clomiphene Citrate in Obese Women With Polycystic Ovary Syndrome
- Conditions
- First Posted Date
- 2000-05-03
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- National Center for Research Resources (NCRR)
- Target Recruit Count
- 88
- Registration Number
- NCT00005654
Randomized Study of Decreased Hyperinsulinemia on the Ovulatory Response to Clomiphene Citrate in Women With Polycystic Ovary Syndrome
- Conditions
- First Posted Date
- 2000-04-07
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- National Center for Research Resources (NCRR)
- Target Recruit Count
- 99
- Registration Number
- NCT00005104
- Locations
- 🇺🇸
Louisiana State University School of Medicine, Shreveport, Louisiana, United States
🇺🇸Washington University - St. Louis, St. Louis, Missouri, United States
🇮🇹University Alma Mater, Bologna, Italy
Diabetes Prevention Program
- Conditions
- Interventions
- First Posted Date
- 2000-03-20
- Last Posted Date
- 2018-03-02
- Target Recruit Count
- 3234
- Registration Number
- NCT00004992
- Locations
- 🇺🇸
George Washington University Biostatistics Center, Suite 750, 6110 Executive Blvd, Rockville, Maryland, United States
Drug Development Updates
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