Dexketoprofen: A Comprehensive Pharmacological and Clinical Review

1. Introduction to Dexketoprofen

1.1. Overview and Background

Dexketoprofen is a well-established non-steroidal anti-inflammatory drug (NSAID) recognized for its analgesic, anti-inflammatory, and antipyretic properties.[1] It holds a specific place in pharmacology as the S(+)-enantiomer of racemic ketoprofen. This stereoisomer is the pharmacologically active component, responsible for the entirety of the therapeutic effects observed with the parent compound, ketoprofen.[1] The development of dexketoprofen as a single enantiomer represents a "chiral switch" from its racemic predecessor, a strategy aimed at optimizing therapeutic action.[4]

The primary clinical application of dexketoprofen is the symptomatic treatment of mild to moderate acute pain across a variety of conditions.[1] Having first received approval in 1994 [1], dexketoprofen is currently available in numerous countries throughout Europe, Asia, and Latin America, where it serves as a common analgesic option.[1] Its utility is particularly noted in situations requiring prompt pain relief.

1.2. Chemical Properties and Formulation

Chemically, dexketoprofen is identified by the International Union of Pure and Applied Chemistry (IUPAC) name (2S)-2-(3-benzoylphenyl)propanoic acid.[1] Its molecular formula is

C16​H14​O3​, corresponding to a molecular weight of approximately 254.28 g/mol.[1] The Chemical Abstracts Service (CAS) registry number for dexketoprofen is 22161-81-5, and it is cataloged in DrugBank under the ID DB09214.