Dextromethorphan
- Generic Name
- Dextromethorphan
- Brand Names
- Auvelity, Benylin DM, Bromfed DM, Broncotron, Cepacol Sore Throat Plus Cough, Cheracol D, Children's Nyquil Cold and Cough, Chloraseptic Sore Throat + Cough, Coricidin Hbp Chest Congestion, Coricidin Hbp Cough and Cold, Creomulsion, DM, Dayquil Cough, Delsym, Delsym Cough Plus Chest Congestion DM, Delsym Cough Plus Soothing Action, Delsym Cough Relief Plus Soothing Action, Despec Reformulated Jun 2008, Diabetic Tussin DM, Dimetapp Long Acting Cough Plus Cold, Diphen, G-zyncof, Mucinex Children's Cough, Mucinex Cough, Mucinex DM, Nuedexta, Nyquil Cough, Pediacare Children's Cough and Congestion, Promethazine DM, Robafen Cough, Robafen DM, Robitussin 12 Hour Cough Relief, Robitussin Cough & Congestion, Robitussin Maximum Strength Cough Plus Chest Congestion DM, Robitussin Nighttime Cough DM, Robitussin Pediatric Cough & Cold LA, Robitussin Pediatric Cough Suppressant, Safetussin DM, Safetussin PM, Scot-tussin DM, Scot-tussin Diabetic CF, Scot-tussin Sugar Free DM, Sudafed PE Children's Cold & Cough, Triaminic Day Time Cold & Cough, Tusnel Diabetic
- Drug Type
- Small Molecule
- Chemical Formula
- C18H25NO
- CAS Number
- 125-71-3
- Unique Ingredient Identifier
- 7355X3ROTS
- Background
Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors.
Dextromethorphan was granted FDA approval before 3 December 1957.
- Indication
Dextromethorphan is indicated in combination with brompheniramine and pseudoephedrine in the treatment of coughs and upper respiratory symptoms associated with allergies or the common cold. Dextromethorphan is also used in combination with guaifenesin as an over-the-counter product to relieve a cough. Dextromethorphan in combination with quinidine is indicated in the treatment of pseudobulbar affect.
- Associated Conditions
- Allergic cough, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Allergies, Coughing caused by Bronchitis, Coughing caused by Flu caused by Influenza, Fever, Flu caused by Influenza, Headache, Irritative cough, Itching of the nose, Itching of the throat, Major Depressive Disorder (MDD), Nasal Congestion, Pseudobulbar Affect (PBA), Rhinorrhoea, Sneezing, Cold or flu syndrome, Upper respiratory symptoms, Watery itchy eyes
- Associated Therapies
- Airway secretion clearance therapy, Bronchodilation, Oropharyngeal antisepsis
Dextromethorphan, Memantine Monotherapy, or Combined Use of Dextromethorphan and Memantine in Amphetamine Addiction
- Conditions
- PharmacotherapyAmphetamine Addiction
- Interventions
- First Posted Date
- 2020-12-29
- Last Posted Date
- 2020-12-29
- Lead Sponsor
- National Cheng-Kung University Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT04687566
- Locations
- 🇨🇳
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Drug-drug Interaction Study of KL1333 in Healthy Subjects
- Conditions
- Mitochondrial Disease
- Interventions
- First Posted Date
- 2020-11-25
- Last Posted Date
- 2021-10-20
- Lead Sponsor
- Abliva AB
- Target Recruit Count
- 14
- Registration Number
- NCT04643249
- Locations
- 🇬🇧
Volunteer recruitment center Covance Leeds Covance Leeds, Leeds, United Kingdom
Assessing the Pharmacokinetics and Drug Interaction Liability of Kratom, an Opioid-like Natural Product
- Conditions
- Interaction Drug Food
- Interventions
- First Posted Date
- 2020-05-18
- Last Posted Date
- 2023-12-20
- Lead Sponsor
- Washington State University
- Target Recruit Count
- 15
- Registration Number
- NCT04392011
- Locations
- 🇺🇸
Washington State University College of Pharmacy and Pharmaceutical Sciences, Spokane, Washington, United States
Intensive Glycemic Control For Diabetic Foot Ulcer Healing
- First Posted Date
- 2020-03-26
- Last Posted Date
- 2021-11-02
- Lead Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
- Target Recruit Count
- 326
- Registration Number
- NCT04323462
- Locations
- 🇮🇳
IPGMER, Kolkata, West Bengal, India
🇮🇳Deptt of Endocrinology, Chandigarh, India
Three Dosing Regimens of Dextromethorphan (DXM) Reportedly Used in Major Depressive Disorder
- Conditions
- MDDTreatment Resistant DepressionSmoking CessationSmoking
- Interventions
- First Posted Date
- 2020-01-13
- Last Posted Date
- 2022-11-04
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 5
- Registration Number
- NCT04226352
- Locations
- 🇺🇸
Johns Hopkins Department of Psychiatry, Baltimore, Maryland, United States
Endobiotics for Phenotyping of Human Cytochrome P450 Enzymes
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2019-12-05
- Last Posted Date
- 2022-01-04
- Lead Sponsor
- Jules Desmeules
- Target Recruit Count
- 40
- Registration Number
- NCT04188028
- Locations
- 🇨🇭
HUG, Geneva, Switzerland
Periarticular Injection Versus Peripheral Nerve Block in Total Hip Arthroplasty
- Conditions
- Hip Arthropathy
- Interventions
- First Posted Date
- 2019-06-06
- Last Posted Date
- 2022-09-23
- Lead Sponsor
- Yale University
- Target Recruit Count
- 192
- Registration Number
- NCT03977454
- Locations
- 🇺🇸
Yale-New Haven Hospital St Raphael, New Haven, Connecticut, United States
Licorice Botanical Dietary Supplements - Metabolism and Safety in Women
- Conditions
- Food-drug Interaction
- Interventions
- Dietary Supplement: Licorice
- First Posted Date
- 2019-05-13
- Last Posted Date
- 2023-05-06
- Lead Sponsor
- University of Illinois at Chicago
- Target Recruit Count
- 19
- Registration Number
- NCT03948243
- Locations
- 🇺🇸
University of Illinois at Chicago, Chicago, Illinois, United States
Impact of Nuedexta on Bulbar Physiology and Function in ALS
- Conditions
- Amyotrophic Lateral Sclerosis
- Interventions
- First Posted Date
- 2019-03-21
- Last Posted Date
- 2023-03-08
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 28
- Registration Number
- NCT03883581
- Locations
- 🇺🇸
Phil Smith Neuroscience Institute at Holy Cross Hospital, Fort Lauderdale, Florida, United States
🇺🇸University of Florida, Gainesville, Florida, United States
Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors
- Conditions
- Metastatic MelanomaAdvanced Solid Tumors
- Interventions
- First Posted Date
- 2019-03-06
- Last Posted Date
- 2023-06-08
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 56
- Registration Number
- NCT03864042
- Locations
- 🇨🇦
Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
🇺🇸UC Irvine Health, Orange, California, United States
🇺🇸University of Colorado Hospital - Anschutz Cancer Pavilion (ACP), Aurora, Colorado, United States
Drug Development Updates
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