Dextromethorphan

Generic Name: Dextromethorphan

Brand Names: Auvelity, Benylin DM, Bromfed DM, Broncotron, Cepacol Sore Throat Plus Cough, Cheracol D, Children's Nyquil Cold and Cough, Chloraseptic Sore Throat + Cough, Coricidin Hbp Chest Congestion, Coricidin Hbp Cough and Cold, Creomulsion, DM, Dayquil Cough, Delsym, Delsym Cough Plus Chest Congestion DM, Delsym Cough Plus Soothing Action, Delsym Cough Relief Plus Soothing Action, Despec Reformulated Jun 2008, Diabetic Tussin DM, Dimetapp Long Acting Cough Plus Cold, Diphen, G-zyncof, Mucinex Children's Cough, Mucinex Cough, Mucinex DM, Nuedexta, Nyquil Cough, Pediacare Children's Cough and Congestion, Promethazine DM, Robafen Cough, Robafen DM, Robitussin 12 Hour Cough Relief, Robitussin Cough & Congestion, Robitussin Maximum Strength Cough Plus Chest Congestion DM, Robitussin Nighttime Cough DM, Robitussin Pediatric Cough & Cold LA, Robitussin Pediatric Cough Suppressant, Safetussin DM, Safetussin PM, Scot-tussin DM, Scot-tussin Diabetic CF, Scot-tussin Sugar Free DM, Sudafed PE Children's Cold & Cough, Triaminic Day Time Cold & Cough, Tusnel Diabetic

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₅NO

CAS Number: 125-71-3

Unique Ingredient Identifier: 7355X3ROTS

Background: Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors.

Dextromethorphan was granted FDA approval before 3 December 1957.

Indication: Dextromethorphan is indicated in combination with brompheniramine and pseudoephedrine in the treatment of coughs and upper respiratory symptoms associated with allergies or the common cold. Dextromethorphan is also used in combination with guaifenesin as an over-the-counter product to relieve a cough. Dextromethorphan in combination with quinidine is indicat...

Associated Conditions: Allergic cough, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Allergies, Coughing caused by Bronchitis, Coughing caused by Flu caused by Influenza, Fever, Flu caused by Influenza, Headache, Irritative cough, Itching of the nose, Itching of the throat, Major Depressive Disorder (MDD), Nasal Congestion, Pseudobulbar Affect (PBA), Rhinorrhoea, Sneezing, Cold or flu syndrome, Upper respiratory symptoms, Watery itchy eyes

Associated Therapies: Airway secretion clearance therapy, Bronchodilation, Oropharyngeal antisepsis

Clinical Trials

Development of Minidose Inje Cocktail Method for Simultaneous Evaluating Five Cytochrome P450 Isoforms in Human

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Omeprazole
Drug: Dextromethorphan
Drug: Losartan
Drug: Cocktail
Drug: Caffeine
Drug: Midazolam

First Posted Date: 2012-04-04

Last Posted Date: 2012-04-04

Lead Sponsor: Inje University

Target Recruit Count: 26

Registration Number: NCT01570569

Effect of N-methyl D-aspartate (NMDA) Receptor Antagonist Dextromethorphan on Opiods Analgesia and Tolerance in Pediatric Intensive Care Unit Patients

Not Applicable

Conditions: Analgesia Tolerance
Pain
Opioid Tolerance

Interventions: Drug: Dextromethorphan
Drug: Placebo

First Posted Date: 2012-03-14

Last Posted Date: 2015-04-14

Lead Sponsor: King Abdullah International Medical Research Center

Target Recruit Count: 36

Registration Number: NCT01553435

Locations: 🇸🇦
King Abdul Aziz Medical City, Riyadh, Central, Saudi Arabia

Placebo Controlled Trial of Dextromethorphan in Rett Syndrome

Phase 2

Completed

Conditions: Rett Syndrome

Interventions: Drug: placebo
Drug: dextromethorphan

First Posted Date: 2012-01-27

Last Posted Date: 2018-12-04

Lead Sponsor: Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

Target Recruit Count: 57

Registration Number: NCT01520363

Locations: 🇺🇸
The Johns Hopkins Institute for Clinical and Translational Research, Baltimore, Maryland, United States

An Open-Label Immunogenicity and Pharmacokinetics Study of Daclizumab High Yield Process Prefilled Syringe in Relapsing Remitting Multiple Sclerosis

Phase 3

Completed

Conditions: Relapsing-Remitting Multiple Sclerosis

Interventions: Drug: Midazolam
Other: Caffeine
Drug: S-warfarin
Other: Vitamin K
Drug: Omeprazole
Drug: Dextromethorphan
Biological: BIIB019 (Daclizumab)

First Posted Date: 2011-10-31

Last Posted Date: 2017-03-14

Lead Sponsor: Biogen

Target Recruit Count: 133

Registration Number: NCT01462318

Locations: 🇵🇱
Research Site, Krakow, Poland

Dextromethorphan, Amantadine and Glucose Homeostasis in Diabetes Subjects

Phase 2

Completed

Conditions: Type 2 Diabetes Mellitus

First Posted Date: 2011-09-28

Last Posted Date: 2012-07-12

Lead Sponsor: Profil Institut für Stoffwechselforschung GmbH

Target Recruit Count: 20

Registration Number: NCT01441986

Locations: 🇩🇪
Profil Institute for Metabolic Research, Neuss, NRW, Germany

Dextromethorphan for Diabetic Macular Edema

Phase 1

Completed

Conditions: Diabetic Macular Edema

Interventions: Drug: Dextromethorphan hydrobromide

First Posted Date: 2011-09-27

Last Posted Date: 2020-07-28

Lead Sponsor: National Eye Institute (NEI)

Target Recruit Count: 7

Registration Number: NCT01441102

Locations: 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States

Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan Dose Response Clinical Trial

Phase 2

Completed

Conditions: Central Neuropathic Pain
Allodynia
Spinal Cord Injury

Interventions: Drug: Dextromethorphan

First Posted Date: 2011-09-19

Last Posted Date: 2017-04-04

Lead Sponsor: Brigham and Women's Hospital

Target Recruit Count: 26

Registration Number: NCT01435798

Locations: 🇺🇸
Translational Pain Research, Brigham and Women's Hospital, Boston, Massachusetts, United States

Acute Cough Study In Children

Phase 4

Terminated

Conditions: Common Cold
Infections, Upper Respiratory Tract

Interventions: Drug: Dextromethorphan
Drug: Placebo

First Posted Date: 2010-12-09

Last Posted Date: 2012-09-20

Lead Sponsor: Pfizer

Target Recruit Count: 140

Registration Number: NCT01257542

Locations: 🇺🇸
DMI Research, Pinellas, Florida, United States
🇺🇸
Cyn3rgy Research, Gresham, Oregon, United States
🇺🇸
Clinical Research Associates Incorporated, Nashville, Tennessee, United States

and more 1 locations