Naltrexone
- Generic Name
- Naltrexone
- Brand Names
- Contrave, Embeda, Vivitrol
- Drug Type
- Small Molecule
- Chemical Formula
- C20H23NO4
- CAS Number
- 16590-41-3
- Unique Ingredient Identifier
- 5S6W795CQM
- Background
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
- Indication
Used as an adjunct to a medically supervised behaviour modification program in the maintenance of opiate cessation in individuals who were formerly physically dependent on opiates and who have successfully undergone detoxification. Also used for the management of alcohol dependence in conjunction with a behavioural modification program.
- Associated Conditions
- Alcohol Dependency, Cholestatic pruritus, Obesity, Opioid Dependence, Severe Pain
- Associated Therapies
- -
Trial to Evaluate the Effects of Naltrexone in Nonsuicidal Self-injury
- Conditions
- Interventions
- First Posted Date
- 2024-10-02
- Last Posted Date
- 2024-10-04
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 150
- Registration Number
- NCT06622239
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder
- First Posted Date
- 2024-05-23
- Last Posted Date
- 2024-07-18
- Lead Sponsor
- Milky Kohno
- Target Recruit Count
- 100
- Registration Number
- NCT06426303
- Locations
- 🇺🇸
VA Portland Health Care System, Portland, Oregon, United States
Efficacy of Baclofen Vs Naltrexon in Achieving & Maintaining Abstinence in Alcohol Dependence.
- Conditions
- Interventions
- First Posted Date
- 2023-12-19
- Last Posted Date
- 2023-12-19
- Lead Sponsor
- Institute of Liver and Biliary Sciences, India
- Target Recruit Count
- 110
- Registration Number
- NCT06175507
- Locations
- 🇮🇳
Institute of Liver & Biliary Sciences (ILBS), New Delhi, Delhi, India
Naltrexone and Propranolol Combined With Immunotherapy
- First Posted Date
- 2023-08-01
- Last Posted Date
- 2023-11-15
- Lead Sponsor
- Ryan Stephenson
- Target Recruit Count
- 12
- Registration Number
- NCT05968690
- Locations
- 🇺🇸
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States
Multi-Center Study of Naltrexone-Acetaminophen in Acute Migraine, With an Exploratory Analysis of Co-occurring Anxiety
- Conditions
- Interventions
- First Posted Date
- 2023-01-17
- Last Posted Date
- 2024-03-19
- Lead Sponsor
- Allodynic Therapeutics, Inc
- Target Recruit Count
- 300
- Registration Number
- NCT05685225
Naltrexone Neuroimaging in Teens with Eating Disorders
- Conditions
- Interventions
- First Posted Date
- 2022-08-22
- Last Posted Date
- 2024-11-04
- Lead Sponsor
- Children's Mercy Hospital Kansas City
- Target Recruit Count
- 60
- Registration Number
- NCT05509257
- Locations
- 🇺🇸
Children's Mercy Research Institute, Kansas City, Missouri, United States
Lemborexant Augmentation of Naltrexone for Alcohol Craving and Sleep
- First Posted Date
- 2022-07-14
- Last Posted Date
- 2024-02-28
- Lead Sponsor
- Baylor College of Medicine
- Target Recruit Count
- 8
- Registration Number
- NCT05458609
- Locations
- 🇺🇸
The Menninger Clinic, Houston, Texas, United States
Glutamate and Opioid Mechanisms of Antidepressant Response to Ketamine
- Conditions
- Interventions
- First Posted Date
- 2021-07-27
- Last Posted Date
- 2023-03-02
- Lead Sponsor
- King's College London
- Target Recruit Count
- 27
- Registration Number
- NCT04977674
- Locations
- 🇬🇧
King's College London, London, United Kingdom
Naltrexone Neuroimaging
- Conditions
- Interventions
- First Posted Date
- 2021-06-23
- Last Posted Date
- 2023-10-12
- Lead Sponsor
- Children's Mercy Hospital Kansas City
- Target Recruit Count
- 13
- Registration Number
- NCT04935931
- Locations
- 🇺🇸
Children's Mercy Research Institute, Kansas City, Missouri, United States
Opioid Modulation and Neural Reward Activation in Healthy Adults
- Conditions
- Interventions
- First Posted Date
- 2021-04-22
- Last Posted Date
- 2023-11-28
- Lead Sponsor
- University of Colorado, Denver
- Target Recruit Count
- 13
- Registration Number
- NCT04854551
- Locations
- 🇺🇸
University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.