Doxorubicin

Generic Name
Doxorubicin
Brand Names
Adriamycin, Doxil, Myocet, Caelyx pegylated liposomal, Zolsketil pegylated liposomal, Myocet liposomal (previously Myocet), Celdoxome pegylated liposomal
Drug Type
Small Molecule
Chemical Formula
C27H29NO11
CAS Number
23214-92-8
Unique Ingredient Identifier
80168379AG
Background

Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970. Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its deta...

Indication

Doxorubicin is indicated for the treatment of neoplastic conditions like acute lymphoblastic leukemia, acute myeloblastic leukemia, Hodgkin and non-Hodgkin lymphoma, metastatic breast cancer, metastatic Wilms’ tumor, metastatic neuroblastoma, metastatic soft tissue and bone sarcomas, metastatic ovarian carcinoma, metastatic transitional cell bladder carcinom...

Associated Conditions
AIDS-related Kaposi's Sarcoma, Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia, Advanced Endometrial Cancer, Advanced Ovarian Cancer, Breast Cancer, Hodgkin's Lymphoma, Metastatic Bone Sarcomas, Metastatic Breast Cancer, Metastatic Soft Tissue Sarcoma, Metastatic Thyroid Cancer, Metastatic Urothelial Cancer, Multiple Myeloma (MM), Mycosis Fungoides (MF), Non-Hodgkin's Lymphoma (NHL), Sezary Syndrome, Waldenström's Macroglobulinemia (WM), Advanced Thymoma, Advanced uterine sarcoma, Metastatic Bronchogenic Carcinoma, Metastatic Gastric carcinoma, Metastatic Neuroblastoma, Metastatic Ovarian carcinoma, Metastatic Wilms' tumor
Associated Therapies
-

Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS-Related Primary Central Nervous System Lymphoma

Phase 2
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2012-11-01
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
33
Registration Number
NCT00000801
Locations
🇺🇸

Julio Arroyo, West Columbia, South Carolina, United States

🇺🇸

San Francisco Gen Hosp, San Francisco, California, United States

🇺🇸

San Francisco AIDS Clinic / San Francisco Gen Hosp, San Francisco, California, United States

and more 4 locations

Phase II Study of Filgrastim (G-CSF) Plus ABVD in the Treatment of HIV-Associated Hodgkin's Disease

Phase 2
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-10-27
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
27
Registration Number
NCT00000626
Locations
🇺🇸

St. Louis ConnectCare, Infectious Diseases Clinic, Saint Louis, Missouri, United States

🇺🇸

SUNY - Buffalo, Erie County Medical Ctr., Buffalo, New York, United States

🇺🇸

The Ohio State Univ. AIDS CRS, Columbus, Ohio, United States

and more 5 locations

A Study of Chemotherapy Plus ddI or ddC in the Treatment of AIDS-Related Kaposi's Sarcoma

Phase 1
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-10-29
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
72
Registration Number
NCT00000954
Locations
🇺🇸

USC CRS, Los Angeles, California, United States

🇺🇸

Ucsf Aids Crs, San Francisco, California, United States

🇺🇸

UCLA CARE Center CRS, Los Angeles, California, United States

and more 11 locations

A Phase I Study of the Combination of Recombinant GM-CSF, AZT, and Chemotherapy (ABV) (Adriamycin, Bleomycin, Vincristine) in AIDS and Kaposi's Sarcoma

Phase 1
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-11-03
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
24
Registration Number
NCT00000681
Locations
🇺🇸

UCLA CARE Center CRS, Los Angeles, California, United States

🇺🇸

Pitt CRS, Pittsburgh, Pennsylvania, United States

🇺🇸

SUNY - Buffalo, Erie County Medical Ctr., Buffalo, New York, United States

and more 2 locations

A Phase III Randomized Trial of Low-Dose Versus Standard-Dose mBACOD Chemotherapy With rGM-CSF for Treatment of AIDS-Associated Non-Hodgkin's Lymphoma

Phase 3
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-11-03
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
250
Registration Number
NCT00000658
Locations
🇺🇸

UCLA CARE Center CRS, Los Angeles, California, United States

🇺🇸

USC CRS, Los Angeles, California, United States

🇺🇸

Ucsf Aids Crs, San Francisco, California, United States

and more 19 locations

A Study of Doxorubicin in the Treatment of AIDS-Related Kaposi's Sarcoma

Phase 2
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-11-04
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
48
Registration Number
NCT00000996
Locations
🇺🇸

Univ of Miami School of Medicine, Miami, Florida, United States

🇺🇸

UCLA CARE Ctr, Los Angeles, California, United States

🇺🇸

San Francisco AIDS Clinic / San Francisco Gen Hosp, San Francisco, California, United States

and more 9 locations

A Study of Chemotherapy Plus Azidothymidine in the Treatment of Kaposi's Sarcoma in Patients With AIDS

Phase 1
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-11-04
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
36
Registration Number
NCT00000987
Locations
🇺🇸

UCLA CARE Center CRS, Los Angeles, California, United States

Chemotherapy and Azidothymidine, With or Without Radiotherapy, for High Grade Lymphoma in AIDS-Risk Group Members

Not Applicable
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-11-03
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
45
Registration Number
NCT00000703
Locations
🇺🇸

Univ of Massachusetts Med Ctr, Worcester, Massachusetts, United States

🇺🇸

Julio Arroyo, West Columbia, South Carolina, United States

🇺🇸

Milton S Hershey Med Ctr, Hershey, Pennsylvania, United States

and more 11 locations

Phase I Trial of mBACOD and Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in AIDS-Associated Large Cell, Immunoblastic, and Small Non-cleaved Lymphoma

Phase 1
Completed
Conditions
First Posted Date
2001-08-31
Last Posted Date
2021-11-02
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
18
Registration Number
NCT00000689
Locations
🇺🇸

USC CRS, Los Angeles, California, United States

Phase I/II Trial of Doxil and Hyperthermia for Breast Cancer Patients With Chest Wall Recurrence or Stage IV Disease With Locally Advanced Breast Cancer

Phase 2
Conditions
First Posted Date
2000-11-06
Last Posted Date
2005-06-24
Lead Sponsor
National Center for Research Resources (NCRR)
Registration Number
NCT00006433
Locations
🇺🇸

Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States

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