Pinaverium
- Generic Name
- Pinaverium
- Brand Names
- Dicetel
- Drug Type
- Small Molecule
- Chemical Formula
- C26H41BrNO4
- CAS Number
- 59995-65-2
- Unique Ingredient Identifier
- U2368VVE7O
- Background
Pinaverium is a spasmolytic agent used for functional gastrointestinal disorders. It is a quaternary ammonium compound that acts as an atypical calcium antagonist to restore normal bowel function. It is shown to relieve GI spasm and pain, transit disturbances and other symptoms related to motility disorders and may be considered as effective first-lline therapy for patients with irritable bowel syndrome (IBS) . Pinaverium bromide is the common ingredient in formulations, mostly as oral tablets. Although it is not a currently approved drug by the FDA, pinaverium is available in over 60 countries including Canada.
- Indication
Pinaverium is indicated for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract.
- Associated Conditions
- Flatulence, Irritable Bowel Syndrome (IBS), Functional disorders of the biliary tract, Stomach cramps
- Associated Therapies
- -
Pinaverium and Herbs for Irritable Bowel Syndrome Treatment: an Onset and Offset Study (PHIBEST)
- Conditions
- Irritable Bowel Syndrome
- Interventions
- Device: AtractylodesDrug: PlaceboDrug: PinaveriumDevice: Paeonia LactifloraDevice: Tangerine PeelDrug: Ledebouriella RootDrug: Radix codonopsitisDrug: Radix curcumaeDrug: Fingered citronDrug: Tuckahoe
- First Posted Date
- 2015-01-01
- Last Posted Date
- 2016-11-22
- Lead Sponsor
- Macrohard Institute of Health
- Target Recruit Count
- 800
- Registration Number
- NCT02330029
- Locations
- 🇨🇳
Second Jiangsu Provincial Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, China
🇨🇳Beijing Xuanwu Hospital of Traditional Chinese Medicine affiliated to Capital Medical University., Beijing, China
🇨🇳Shanghai First People's Hospital affiliated to Shanghai Tiao Tong University, Shanghai, China
A Randomized, Double-blind, and Placebo-controlled Study on the Treatments of Irritable Bowel Syndrome
- Conditions
- Irritable Bowel Syndrome
- Interventions
- Device: AtractylodesDrug: PinaveriumDrug: PlaceboDevice: Paeonia LactifloraDevice: Tangerine PeelDrug: Ledebouriella RootDrug: Radix codonopsitisDrug: Radix curcumaeDrug: Fingered citronDrug: Tuckahoe
- First Posted Date
- 2012-07-16
- Last Posted Date
- 2014-05-12
- Lead Sponsor
- University of Minnesota
- Target Recruit Count
- 800
- Registration Number
- NCT01641224
- Locations
- 🇨🇳
Shanghai First People's Hospital affiliated to Shanghai Tiao Tong University, Shanghai, China
🇨🇳Beijing Xuanwu Hospital of Traditional Chinese Medicine affiliated to Capital Medical University., Beijing, China
🇨🇳Second Jiangsu Provincial Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, China
Drug Development Updates
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