Neosaxitoxin
- Generic Name
- Neosaxitoxin
- Drug Type
- Small Molecule
- Chemical Formula
- C10H17N7O5
- CAS Number
- 64296-20-4
- Unique Ingredient Identifier
- 6YRL8BWD9H
- Background
Neosaxitoxin is under investigation in clinical trial NCT01786655 (Safety Study of Long-Acting Local Anesthetic).
A Study in Healthy Male Volunteers to Investigate the Safety and Tolerability of a Single Dose of Neosaxitoxin Alone and in Combination With Bupivacaine (With and Without Epinephrine) for Brachial Plexus Blockade
Phase 1
Terminated
- Conditions
- Anesthesia, LocalAnesthesiaAnalgesia
- Interventions
- Combination Product: Neosaxitoxin combined with bupivacaine low (T2)Combination Product: Neosaxitoxin combined with bupivacaine low and epinephrine (T1)Combination Product: Bupivacaine low combined with epinephrine (C1)Combination Product: Neosaxitoxin combined with epinephrine (T4)Combination Product: Bupivacaine high combined with epinephrine (C2)Combination Product: Neosaxitoxin combined with bupivacaine low and epinephrineCombination Product: Neosaxitoxin combined with bupivacaine low
- First Posted Date
- 2018-01-16
- Last Posted Date
- 2018-10-11
- Lead Sponsor
- Grünenthal GmbH
- Target Recruit Count
- 242
- Registration Number
- NCT03399435
- Locations
- 🇳🇱
NL001, Groningen, Netherlands
Safety Study of Long-Acting Local Anesthetic
Phase 1
Completed
- Conditions
- Safety of Neosaxitoxin in Healthy Volunteers
- Interventions
- Drug: NeoSTX + bupivacaine 0.2%Drug: NeoSTX + bupivacaine 0.2% + epinephrine 5mcg/mlOther: Saline placebo
- First Posted Date
- 2013-02-08
- Last Posted Date
- 2016-02-17
- Lead Sponsor
- Charles Berde
- Target Recruit Count
- 105
- Registration Number
- NCT01786655
- Locations
- 🇺🇸
Boston Children's Hospital, Boston, Massachusetts, United States
Local Anesthetic Properties of Neosaxitoxin
Phase 1
Completed
- Conditions
- Healthy Volunteers
- First Posted Date
- 2006-01-09
- Last Posted Date
- 2007-02-19
- Lead Sponsor
- University of Chile
- Target Recruit Count
- 10
- Registration Number
- NCT00273065
- Locations
- 🇨🇱
Henry Mayer Center, Hospital Clínico Universidad de Chile, Santiago, Chile
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