Etoposide

Generic Name
Etoposide
Brand Names
Etopophos, Toposar, Vepesid
Drug Type
Small Molecule
Chemical Formula
C29H32O13
CAS Number
33419-42-0
Unique Ingredient Identifier
6PLQ3CP4P3
Background

A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to ce...

Indication

For use in combination with other chemotherapeutic agents in the treatment of refractory testicular tumors and as first line treatment in patients with small cell lung cancer. Also used to treat other malignancies such as lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme.

Associated Conditions
Acute Lymphoblastic Leukaemias (ALL), Acute Myeloid Leukemia, Advanced Hodgkin's Lymphoma, Ewing's Sarcoma, Gestational Trophoblastic Neoplasia, Merkel cell cancer, Multiple Myeloma (MM), Neuroblastoma (NB), Neuroendocrine Tumors, Non-Hodgkin's Lymphomas, Non-Small Cell Lung Cancer (NSCLC), Osteosarcoma, Ovarian Cancer, Prostate Cancer, Retinoblastoma, Small Cell Lung Cancer (SCLC), Wilms' tumor, Locally advanced Thymoma, Metastatic Thymic Cancer, Refractory Sarcoma, Refractory Testicular cancer
Associated Therapies
-

Surgery in Treating Children With Neuroblastoma

First Posted Date
2003-01-27
Last Posted Date
2017-03-13
Lead Sponsor
Children's Oncology Group
Target Recruit Count
968
Registration Number
NCT00003119
Locations
🇺🇸

University of Chicago Cancer Research Center, Chicago, Illinois, United States

🇺🇸

Rush University Medical Center, Chicago, Illinois, United States

🇺🇸

University of Illinois Medical Center, Chicago, Illinois, United States

and more 231 locations

Combination Chemotherapy Alone or With Radiation Therapy in Treating Children With Kidney Cancer

First Posted Date
2003-01-27
Last Posted Date
2021-02-25
Lead Sponsor
Children's Oncology Group
Target Recruit Count
3031
Registration Number
NCT00002611
Locations
🇺🇸

Children's Hospital Central California, Madera, California, United States

🇺🇸

Maine Children's Cancer Program, Scarborough, Maine, United States

🇺🇸

Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, United States

and more 231 locations

Combination Chemotherapy in Treating Patients With Previously Untreated Advanced Hodgkin's Lymphoma

Phase 3
Conditions
First Posted Date
2003-01-27
Last Posted Date
2013-09-20
Lead Sponsor
Mount Vernon Cancer Centre at Mount Vernon Hospital
Target Recruit Count
850
Registration Number
NCT00041210
Locations
🇬🇧

Pinderfields General Hospital, Wakefield, Scotland, United Kingdom

🇬🇧

Aintree University Hospital, Liverpool, England, United Kingdom

🇬🇧

City Hospital - Birmingham, West Bromwich, England, United Kingdom

and more 34 locations

Combination Chemotherapy in Treating Patients With Stage I, II, or IIIA Non-small Cell Lung Cancer That Has Been Surgically Removed

Phase 3
Conditions
First Posted Date
2003-01-27
Last Posted Date
2013-09-20
Lead Sponsor
European Institute of Oncology
Target Recruit Count
750
Registration Number
NCT00003053
Locations
🇮🇹

Ospedale San Filippo Neri, Rome, Italy

🇮🇹

Universita Degli Studi di Bari Policlinico, Bari, Italy

🇮🇹

Ospedale Oncologico A. Businco, Cagliari, Italy

and more 82 locations

Combination Chemotherapy in Treating Patients Who Have Extensive-Stage Small Cell Lung Cancer

Phase 3
Conditions
First Posted Date
2003-01-27
Last Posted Date
2013-09-17
Lead Sponsor
Commissie Voor Klinisch Toegepast Onderzoek
Target Recruit Count
250
Registration Number
NCT00003696
Locations
🇳🇱

Vrije Universiteit Medisch Centrum, Amsterdam, Netherlands

Combination Chemotherapy Followed by Surgery and Peripheral Stem Cell or Bone Marrow Transplantation in Treating Infants With Newly Diagnosed Neuroblastoma

Phase 2
Completed
Conditions
First Posted Date
2003-01-27
Last Posted Date
2013-09-17
Lead Sponsor
European Infant Neuroblastoma Study Group - 1999
Registration Number
NCT00025649
Locations
🇸🇪

Ostra Sjukhuset, Gothenburg, Sweden

🇫🇷

Centre Hospitalier Regional de Purpan, Toulouse, France

🇳🇴

Rikshospitalet University Hospital, Oslo, Norway

and more 8 locations

Combination Chemotherapy in Treating Infants With Newly Diagnosed Neuroblastoma

Phase 2
Completed
Conditions
First Posted Date
2003-01-27
Last Posted Date
2013-09-17
Lead Sponsor
European Infant Neuroblastoma Study Group - 1999
Registration Number
NCT00025610
Locations
🇨🇭

Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

🇦🇹

St. Anna Children's Hospital, Vienna, Austria

🇧🇪

Universitair Ziekenhuis Gent, Ghent, Belgium

and more 9 locations

Combination Chemotherapy Followed by Surgery in Treating Infants With Newly Diagnosed Neuroblastoma

Phase 2
Completed
Conditions
First Posted Date
2003-01-27
Last Posted Date
2013-09-17
Lead Sponsor
European Infant Neuroblastoma Study Group - 1999
Registration Number
NCT00025623
Locations
🇳🇴

Rikshospitalet University Hospital, Oslo, Norway

🇨🇭

Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

🇫🇷

Centre Hospitalier Regional de Purpan, Toulouse, France

and more 8 locations

Combination Chemotherapy With or Without Hyperthermia Therapy in Treating Patients With Soft Tissue Sarcoma

Phase 3
Completed
Conditions
First Posted Date
2003-01-27
Last Posted Date
2013-09-17
Lead Sponsor
European Organisation for Research and Treatment of Cancer - EORTC
Target Recruit Count
340
Registration Number
NCT00003052
Locations
🇩🇪

Robert Roessle Comprehensive Cancer Center at University of Berlin - Charite Campus Buch, Berlin, Germany

🇩🇪

Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Germany

🇩🇪

Universitaetsklinikum Essen, Essen, Germany

and more 1 locations

Chemotherapy Followed by Radiation Therapy and Peripheral Stem Cell Transplant Compared With Chemotherapy Plus Interferon Alfa in Treating Patients With Stage III or Stage IV Mantle Cell Lymphoma

Phase 3
Conditions
First Posted Date
2003-01-27
Last Posted Date
2013-09-17
Lead Sponsor
German Low Grade Lymphoma Study Group
Registration Number
NCT00016887
Locations
🇧🇪

AZ Sint-Jan, Brugge, Belgium

🇮🇹

Ospedale Civile Alessandria, Alessandria, Italy

© Copyright 2024. All Rights Reserved by MedPath