Porfimer Sodium
- Generic Name
- Porfimer Sodium
- Brand Names
- Photofrin
- Drug Type
- Small Molecule
- CAS Number
- 87806-31-3
- Unique Ingredient Identifier
- Y3834SIK5F
- Background
The purified component of hematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (hematoporphyrin photoradiation); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of photodynamic therapy in the United States.
- Indication
临床上用于对不能用手术及其他根治疗法的肺、子宫颈癌或需非手术治疗的患者，在内镜下能观察到病灶的全貌、可能进行激光照射的下列疾病：早期肺癌（0期或Ⅰ期）、浅表性食管癌、浅表性早期胃癌、宫颈癌初期及发育异常。
- Associated Conditions
- Barrett's Esophagus, Esophageal Cancer, Completely obstructive Non-small cell lung cancer, Microinvasive endobrachial Non-small cell lung cancer, Partially obstructive Non-small cell lung cancer
Photodynamic Therapy (PDT) For Recurrent High Grade Gliomas
- First Posted Date
- 2013-10-22
- Last Posted Date
- 2019-08-20
- Lead Sponsor
- Harry T Whelan, MD
- Target Recruit Count
- 1
- Registration Number
- NCT01966809
- Locations
- 🇺🇸
Medical College of Wisconsin/ Froedtert Hospital, Milwaukee, Wisconsin, United States
Ultrasound-Guided Photodynamic Therapy With Photofrin & Gemcitabine for Patients With Locally Advanced Pancreatic Cancer
- Conditions
- Acinar Cell Adenocarcinoma of the PancreasDuct Cell Adenocarcinoma of the PancreasStage III Pancreatic Cancer
- Interventions
- Procedure: endoscopic ultrasonographyProcedure: photodynamic therapy
- First Posted Date
- 2013-01-17
- Last Posted Date
- 2018-12-13
- Lead Sponsor
- John DeWitt
- Target Recruit Count
- 12
- Registration Number
- NCT01770132
- Locations
- 🇺🇸
IU Simon Cancer Center, Indianapolis, Indiana, United States
Photodynamic Therapy (PDT) for Recurrent Pediatric Brain Tumors
- Conditions
- Brain Tumor, Recurrent
- Interventions
- First Posted Date
- 2012-09-11
- Last Posted Date
- 2019-02-25
- Lead Sponsor
- Harry T Whelan, MD
- Target Recruit Count
- 5
- Registration Number
- NCT01682746
- Locations
- 🇺🇸
Children's Hospital of Wisconsin, Wauwatosa, Wisconsin, United States
Safety and Efficacy of Photodynamic Therapy for Bile Duct Invasion of Hepatocellular Carcinoma
- Conditions
- Hepatocellular CarcinomaObstructive Jaundice
- Interventions
- First Posted Date
- 2012-01-09
- Last Posted Date
- 2015-11-20
- Lead Sponsor
- Samsung Medical Center
- Target Recruit Count
- 11
- Registration Number
- NCT01506115
- Locations
- 🇰🇷
Samsung Medical Center 81 Irwon-Ro Gangnamgu, Seoul, Korea, Republic of
Photodynamic Therapy Using Porfimer Sodium in Treating Patients With Non-Small Cell Lung Cancer And Bronchial Disease
- First Posted Date
- 2008-09-18
- Last Posted Date
- 2018-07-05
- Target Recruit Count
- 35
- Registration Number
- NCT00754910
- Locations
- 🇺🇸
Ohio State University Medical Center, Columbus, Ohio, United States
Photodynamic Therapy in Treating Patients With Resectable Non-Small Cell Lung Cancer That Has Spread to the Pleura
- Conditions
- Lung CancerMetastatic Cancer
- Interventions
- Drug: chemotherapyOther: immunohistochemistry staining methodOther: laboratory biomarker analysisProcedure: spectroscopyProcedure: therapeutic conventional surgery
- First Posted Date
- 2008-01-28
- Last Posted Date
- 2020-11-24
- Lead Sponsor
- Abramson Cancer Center at Penn Medicine
- Target Recruit Count
- 9
- Registration Number
- NCT00601848
- Locations
- 🇺🇸
Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania, United States
Photodynamic Therapy Using Porfimer Sodium in Treating Patients With Recurrent Mouth or Throat Dysplasia or Recurrent In Situ Cancer or Stage I Cancer of the Mouth or Throat
- Conditions
- Head and Neck Cancer
- Interventions
- Drug: Photdynamic Therapy (PDT)
- First Posted Date
- 2007-09-17
- Last Posted Date
- 2014-07-04
- Lead Sponsor
- Roswell Park Cancer Institute
- Target Recruit Count
- 30
- Registration Number
- NCT00530088
- Locations
- 🇺🇸
Roswell Park Cancer Institute, Buffalo, New York, United States
Biliary Stenting With or Without Photodynamic Therapy in Treating Patients With Locally Advanced, Recurrent, or Metastatic Cholangiocarcinoma or Other Biliary Tract Tumors That Cannot Be Removed by Surgery
- Conditions
- Extrahepatic Bile Duct CancerGallbladder Cancer
- Interventions
- Procedure: biliary stenting
- First Posted Date
- 2007-08-08
- Last Posted Date
- 2013-02-20
- Lead Sponsor
- University College, London
- Target Recruit Count
- 92
- Registration Number
- NCT00513539
- Locations
- 🇬🇧
Aintree University Hospital, Liverpool, England, United Kingdom
🇬🇧Ninewells Hospital, Dundee, Scotland, United Kingdom
🇬🇧University College Hospital, London, England, United Kingdom
Photodynamic Therapy With Porfimer Sodium in Treating Patients With Precancerous Lesions, Cancer, or Other Disease of the Aerodigestive Tract
- Conditions
- Head and Neck CancerPrecancerous/Nonmalignant Condition
- Interventions
- Procedure: Photodynamic Therapy
- First Posted Date
- 2007-03-28
- Last Posted Date
- 2017-02-08
- Lead Sponsor
- University of Miami
- Target Recruit Count
- 45
- Registration Number
- NCT00453336
- Locations
- 🇺🇸
University of Miami Sylvester Comprehensive Cancer Center - Miami, Miami, Florida, United States
Sequential Whole Bladder Photodynamic Therapy (WBPDT) in the Management of Superficial Bladder Cancer
- Conditions
- Superficial Bladder Cancer
- Interventions
- Procedure: Whole bladder laser light treatment as an alternative to radical cystectomy
- First Posted Date
- 2006-05-08
- Last Posted Date
- 2012-10-26
- Lead Sponsor
- North Florida/South Georgia Veterans Health System
- Target Recruit Count
- 22
- Registration Number
- NCT00322699
- Locations
- 🇺🇸
Malcom Randall NF/SG Veterans Administration Health System, Gainesville, Florida, United States
Drug Development Updates
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