Minocycline
- Generic Name
- Minocycline
- Brand Names
- Amzeeq, Arestin, Dynacin, Minocin, Minolira, Solodyn, Ximino, Zilxi
- Drug Type
- Small Molecule
- Chemical Formula
- C23H27N3O7
- CAS Number
- 10118-90-8
- Unique Ingredient Identifier
- FYY3R43WGO
- Background
Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines.
Minocycline was granted FDA approval on 30 June 1971.
- Indication
Oral and topical minocycline are indicated to treat inflammatory lesions of acne vulgaris. Subgingival microspheres are indicated as an adjunct treatment in the reduction of pocket depth in adults with periodontitis. Oral and intravenous formulations are indicated to treat infections of susceptible microorganisms. These include rickettsiae, Mycoplasma pneumoniae, Chlamydia trachomatis, Chlamydophila psittaci, Chlamydia trachomatis, Ureaplasma urealyticum, Borrelia recurrentis, Haemophilus ducreyi, Yersinia pestis, Francisella tularensis, Vibrio cholerae, Campylobacter fetus, Brucella species, Bartonella bacilliformis, Klebsiella granulomatis, Escherichia coli, Enterobacter aerogenes, Shigella species, Acinetobacter species, Haemophilus influenzae, and Kelbsiella species.
- Associated Conditions
- Bartonellosis, Brucellosis, Campylobacter fetus, Chancroid, Cholera (Disorder), Conjunctivitis, Inclusion, Granuloma Inguinale, Lymphogranuloma Venereum, Nongonococcal urethritis, Periodontitis, Plague, Psittacosis, Q Fever, Relapsing Fever, Respiratory Tract Infections (RTI), Rickettsia Infections, Rickettsialpox, Rocky Mountain Spotted Fever, Trachoma, Tularemia, Typhus infections, Inflammatory lesions
Pilot Study of Minocycline in Huntington's Disease
- First Posted Date
- 2006-01-16
- Last Posted Date
- 2013-04-19
- Lead Sponsor
- Merit Cudkowicz
- Target Recruit Count
- 114
- Registration Number
- NCT00277355
- Locations
- 🇺🇸
Washington University School of Medicine, St. Louis, Missouri, United States
🇺🇸University of Alabama at Birmingham, Birmingham, Alabama, United States
🇺🇸University of South Florida, Tampa, Florida, United States
Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms
- Conditions
- AneurysmsArteriovenous Malformations
- Interventions
- First Posted Date
- 2005-10-25
- Last Posted Date
- 2013-10-09
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 26
- Registration Number
- NCT00243893
- Locations
- 🇺🇸
University of California, San Francisco, California, United States
Study Comparing Acne in Patients Taking Oral Minocycline to Patients Taking Minocycline Plus Topical Tretinoin
- Conditions
- Acne Vulgaris
- Interventions
- First Posted Date
- 2005-10-18
- Last Posted Date
- 2012-02-24
- Lead Sponsor
- Derm Research @ 888 Inc.
- Target Recruit Count
- 38
- Registration Number
- NCT00240513
- Locations
- 🇨🇦
Derm Research @ 888 Inc, Vancouver, British Columbia, Canada
Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study
- Conditions
- Idiopathic Pulmonary Fibrosis
- First Posted Date
- 2005-09-20
- Last Posted Date
- 2006-09-11
- Lead Sponsor
- University of California, Los Angeles
- Registration Number
- NCT00203697
- Locations
- 🇺🇸
UCLA Pulmonary Outpatient Clinic, Los Angeles, California, United States
Additional Minocycline Pleurodesis After Thoracoscopic Procedures for Primary Spontaneous Pneumothorax
- Conditions
- Pneumothorax
- First Posted Date
- 2005-09-12
- Last Posted Date
- 2005-10-20
- Lead Sponsor
- National Taiwan University Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT00154895
- Locations
- 🇨🇳
Yung-Chie Lee, Taipei, Taiwan
National Institute of Neurological Disorders and Stroke (NINDS) Parkinson's Disease Neuroprotection Trial
- Conditions
- Parkinson's Disease
- First Posted Date
- 2003-06-25
- Last Posted Date
- 2016-01-20
- Lead Sponsor
- University of Rochester
- Target Recruit Count
- 195
- Registration Number
- NCT00063193
- Locations
- 🇺🇸
University of Rochester Medical Center, Rochester, New York, United States
Minocycline to Treat Amyotrophic Lateral Sclerosis
- Conditions
- Amyotrophic Lateral Sclerosis
- First Posted Date
- 2002-10-17
- Last Posted Date
- 2007-12-21
- Target Recruit Count
- 400
- Registration Number
- NCT00047723
- Locations
- 🇺🇸
Drexel University College of Medicine, Hahnemann Campus, Philadelphia, Pennsylvania, United States
🇺🇸University of Vermont, Burlington, Vermont, United States
🇺🇸Methodist Hospital, Houston, Texas, United States
Minocycline in Patients With Huntington's Disease
- Conditions
- Huntington's Disease
- First Posted Date
- 2002-01-25
- Last Posted Date
- 2015-03-25
- Lead Sponsor
- FDA Office of Orphan Products Development
- Target Recruit Count
- 63
- Registration Number
- NCT00029874
- Locations
- 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
Drug Development Updates
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