Minocycline
- Generic Name
- Minocycline
- Brand Names
- Amzeeq, Arestin, Dynacin, Minocin, Minolira, Solodyn, Ximino, Zilxi
- Drug Type
- Small Molecule
- Chemical Formula
- C23H27N3O7
- CAS Number
- 10118-90-8
- Unique Ingredient Identifier
- FYY3R43WGO
- Background
Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines.
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- Indication
Oral and topical minocycline are indicated to treat inflammatory lesions of acne vulgaris. Subgingival microspheres are indicated as an adjunct treatment in the reduction of pocket depth in adults with periodontitis. Oral and intravenous formulations are indicated to treat infections of susceptible microorganisms. These include rickettsiae, Mycoplasma pneumo...
- Associated Conditions
- Bartonellosis, Brucellosis, Campylobacter fetus, Chancroid, Cholera (Disorder), Conjunctivitis, Inclusion, Granuloma Inguinale, Lymphogranuloma Venereum, Nongonococcal urethritis, Periodontitis, Plague, Psittacosis, Q Fever, Relapsing Fever, Respiratory Tract Infections (RTI), Rickettsia Infections, Rickettsialpox, Rocky Mountain Spotted Fever, Trachoma, Tularemia, Typhus infections, Inflammatory lesions
- Associated Therapies
- -
Effects of Minocycline on Patients With Ischemic Stroke Undergoing Intravenous Thrombectomy
- First Posted Date
- 2022-08-04
- Last Posted Date
- 2024-07-23
- Lead Sponsor
- Xijing Hospital
- Target Recruit Count
- 180
- Registration Number
- NCT05487417
- Locations
- 🇨🇳
Xijing Hospital, Xi'an, China
Minocycline for Chronic Autoimmune Uveitis
- First Posted Date
- 2022-07-26
- Last Posted Date
- 2023-04-18
- Lead Sponsor
- Sun Yat-sen University
- Target Recruit Count
- 10
- Registration Number
- NCT05474729
- Locations
- 🇨🇳
Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China
Minocycline Treatment for Cystoid Macular Edema
- First Posted Date
- 2022-07-26
- Last Posted Date
- 2023-04-19
- Lead Sponsor
- Sun Yat-sen University
- Target Recruit Count
- 5
- Registration Number
- NCT05474950
- Locations
- 🇨🇳
Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China
Minocycline Efficacy in Improving Neurological Outcome of Patients Who Undergo Endovascular Revascularization for Acute Ischemic Stroke
- First Posted Date
- 2022-05-10
- Last Posted Date
- 2024-02-08
- Lead Sponsor
- State University of New York at Buffalo
- Target Recruit Count
- 134
- Registration Number
- NCT05367362
Minocycline for Aneurysmal Subarachnoid Hemorrhage (MASH)
- Conditions
- First Posted Date
- 2021-05-06
- Last Posted Date
- 2023-02-10
- Lead Sponsor
- University of Southern California
- Target Recruit Count
- 20
- Registration Number
- NCT04876638
- Locations
- 🇺🇸
University of Southern California Department of Neurosurgery, Los Angeles, California, United States
Neuroinflammation in Hypertension Study
- First Posted Date
- 2020-07-20
- Last Posted Date
- 2022-09-29
- Lead Sponsor
- Royal Perth Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT04478500
- Locations
- 🇦🇺
Royal Perth Hospital, Perth, Western Australia, Australia
Effect of Minocycline on Delirium Incidence in Critically Ill Patients
- First Posted Date
- 2020-01-07
- Last Posted Date
- 2022-05-31
- Target Recruit Count
- 160
- Registration Number
- NCT04219735
- Locations
- 🇧🇷
São José Hospital, Criciuma, SC, Brazil
Neuroimmune Dysfunction in Alcohol Use Disorder
- First Posted Date
- 2019-12-26
- Last Posted Date
- 2023-12-01
- Lead Sponsor
- University of Maryland, Baltimore
- Target Recruit Count
- 142
- Registration Number
- NCT04210713
- Locations
- 🇺🇸
Maryland Psychiatric Research Center (MPRC) Treatment Research Program (TRP), Catonsville, Maryland, United States
Minocycline Treatment in Retinitis Pigmentosa
- Conditions
- Interventions
- First Posted Date
- 2019-08-28
- Last Posted Date
- 2023-12-27
- Lead Sponsor
- Sun Yat-sen University
- Target Recruit Count
- 35
- Registration Number
- NCT04068207
- Locations
- 🇨🇳
Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China
A Proof-of-Concept Study of Minocycline in Autism
- Conditions
- Interventions
- First Posted Date
- 2019-07-24
- Last Posted Date
- 2020-12-08
- Lead Sponsor
- Children's Hospital Medical Center, Cincinnati
- Target Recruit Count
- 53
- Registration Number
- NCT04031755
- Locations
- 🇺🇸
Thompson Center for Autism & Neurodevelopmental Disorders - University of Missouri, Columbia, Missouri, United States
🇺🇸Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
🇺🇸Center for Autism and Developmental Disorders - University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
Drug Development Updates
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