MedPath

Lanabecestat

Generic Name
Lanabecestat
Drug Type
Small Molecule
Chemical Formula
C26H28N4O
CAS Number
1383982-64-6
Unique Ingredient Identifier
X8SPJ492VF
Background

Lanabecestat is under investigation in clinical trial NCT03499041 (A Study of LY3314814 in Participants With Liver Impairment).

A Study of Lanabecestat in Participants With Severe Kidney Impairment Compared to Healthy Participants

Phase 1
Withdrawn
Conditions
Renal Insufficiency
Interventions
First Posted Date
2018-06-04
Last Posted Date
2018-06-28
Lead Sponsor
Eli Lilly and Company
Registration Number
NCT03545087
Locations
🇺🇸

Orange County Research Center, Tustin, California, United States

🇺🇸

Clinical Pharmacology of Miami, Miami, Florida, United States

🇺🇸

Orlando Clinical Research Ctr., Orlando, Florida, United States

A Study of Lanabecestat in Healthy Female Participants Taking Oral Contraceptive

Phase 1
Withdrawn
Conditions
Healthy
Interventions
Drug: Oral Contraceptive
First Posted Date
2018-04-24
Last Posted Date
2018-06-28
Lead Sponsor
Eli Lilly and Company
Registration Number
NCT03506399
Locations
🇸🇬

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri, 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST) or speak with your personal physician., Singapore, Singapore

A Study of LY3314814 in Participants With Liver Impairment

Phase 1
Withdrawn
Conditions
Hepatic Impairment
Interventions
First Posted Date
2018-04-17
Last Posted Date
2018-06-28
Lead Sponsor
Eli Lilly and Company
Registration Number
NCT03499041
Locations
🇺🇸

New Orleans Cntr for Clin Res, Knoxville, Tennessee, United States

🇺🇸

Orange County Research Center, Tustin, California, United States

🇺🇸

Clinical Pharmacology of Miami, Miami, Florida, United States

and more 1 locations

A Study of LY3314814 in Healthy Participants

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: [13C415N3] LY3314814
First Posted Date
2017-07-19
Last Posted Date
2019-10-31
Lead Sponsor
AstraZeneca
Target Recruit Count
8
Registration Number
NCT03222427
Locations
🇬🇧

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri, 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST) or speak with your personal physician., Leeds, West Yorkshire, United Kingdom

A Study of Lanabecestat (LY3314814) in Healthy Participants When Taken With Rosuvastatin

Phase 1
Completed
Conditions
Healthy
Interventions
First Posted Date
2017-01-12
Last Posted Date
2019-11-01
Lead Sponsor
AstraZeneca
Target Recruit Count
42
Registration Number
NCT03019549
Locations
🇺🇸

Covance Clinical Research Inc, Daytona Beach, Florida, United States

A Study of Lanabecestat (LY3314814) in Early Alzheimer's Disease Dementia

Phase 3
Terminated
Conditions
Alzheimer's Disease
Interventions
First Posted Date
2016-11-23
Last Posted Date
2019-12-03
Lead Sponsor
AstraZeneca
Target Recruit Count
421
Registration Number
NCT02972658
Locations
🇺🇸

Brain Matters Research, Delray Beach, Florida, United States

🇺🇸

IMIC, Inc., Palmetto Bay, Florida, United States

🇺🇸

Suncoast Neuroscience Associates, Saint Petersburg, Florida, United States

and more 126 locations

A Study of Lanabecestat (LY3314814) in Participants With Mild Alzheimer's Disease Dementia

Phase 3
Terminated
Conditions
Alzheimer's Disease
Interventions
Drug: Placebo
First Posted Date
2016-05-26
Last Posted Date
2019-12-03
Lead Sponsor
AstraZeneca
Target Recruit Count
1722
Registration Number
NCT02783573
Locations
🇺🇸

Maine Neurology, Scarborough, Maine, United States

🇺🇸

Eastern Maine Medical Center, Bangor, Maine, United States

🇺🇸

Atlanta Center of Medical Research, Atlanta, Georgia, United States

and more 254 locations

A Study of Lanabecestat (LY3314814) in Healthy Participants

Phase 1
Completed
Conditions
Healthy
Interventions
First Posted Date
2016-01-26
Last Posted Date
2019-11-01
Lead Sponsor
AstraZeneca
Target Recruit Count
18
Registration Number
NCT02663128

A Drug-drug Interaction Study of Lanabecestat (LY3314814) in Healthy Participants

Phase 1
Completed
Conditions
Healthy
Interventions
First Posted Date
2015-10-05
Last Posted Date
2019-11-01
Lead Sponsor
AstraZeneca
Target Recruit Count
60
Registration Number
NCT02568397
Locations
🇺🇸

Covance, Dallas, Texas, United States

A Drug Interaction Study of Lanabecestat (LY3314814) and Warfarin in Healthy Participants

Phase 1
Completed
Conditions
Healthy
Interventions
First Posted Date
2015-09-04
Last Posted Date
2019-11-04
Lead Sponsor
AstraZeneca
Target Recruit Count
15
Registration Number
NCT02540668
Locations
🇺🇸

Covance Clinical Research Inc, Evansville, Indiana, United States

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