Natalizumab

Generic Name
Natalizumab
Brand Names
Tysabri, Tyruko
Drug Type
Biotech
Chemical Formula
-
CAS Number
189261-10-7
Unique Ingredient Identifier
3JB47N2Q2P
Background

Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA reintroduced the drug to the market for mu...

Indication

Natalizumab is indicated as monotherapy for the treatment of relapsing forms of multiple sclerosis, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults.
...

Associated Conditions
Relapsing Remitting Multiple Sclerosis (RRMS), Secondary Progressive Multiple Sclerosis (SPMS), Severe Crohn's Disease, Moderate Crohn’s Disease
Associated Therapies
-

Safety and Efficacy of Natalizumab in Combination With Avonex in the Treatment of Multiple Sclerosis

First Posted Date
2002-02-18
Last Posted Date
2009-06-18
Lead Sponsor
Biogen
Target Recruit Count
1200
Registration Number
NCT00030966
Locations
🇺🇸

Mercy Hospital Outpatient Pharmacy, Des Moines, Iowa, United States

🇺🇸

University of Pittsburgh, Department of Neurology, Pittsburgh, Pennsylvania, United States

🇩🇪

Asklepios Klinik Schildautal, Seesen/Harz, Germany

and more 84 locations

Safety and Efficacy of Natalizumab in the Treatment of Multiple Sclerosis

First Posted Date
2001-12-03
Last Posted Date
2017-01-09
Lead Sponsor
Biogen
Target Recruit Count
900
Registration Number
NCT00027300
Locations
🇬🇧

Oldchurch Hospital, Essex, United Kingdom

🇧🇪

National MS Centrum, Melsbroek, Belgium

🇺🇸

University of Miami School of Medicine, Department of Neurology, Miami, Florida, United States

and more 50 locations
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