Prednisolone

Generic Name: Prednisolone

Brand Names: Millipred Dp 6 Day

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₈O_₅

CAS Number: 50-24-8

Unique Ingredient Identifier: 9PHQ9Y1OLM

Background: Prednisolone is a glucocorticoid similar to cortisol used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.

Prednisolone was granted FDA approval on 21 June 1955.

Indication: Prednisolone is indicated to treat endocrine, rheumatic, and hematologic disorders; collagen, dermatologic, ophthalmic, respiratory, and gastrointestinal diseases; allergic and edematous states; and other conditions like tuberculous meningitis.

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Allergic Bronchopulmonary Aspergillosis, Allergic Conjunctivitis (AC), Allergic Contact Dermatitis, Allergic Skin Reaction, Allergic corneal marginal ulcers, Alveolitis, Extrinsic Allergic, Ankylosing Spondylitis (AS), Aspiration Pneumonia, Aspiration Pneumonitis, Atopic Dermatitis, Bell's Palsy, Berylliosis, Bullous dermatitis herpetiformis, Burns, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Corneal injuries, Corneal ulceration, Crohn's Disease (CD), Cyclitis, Dermatomyositis (DM), Dermatosis of the Ear Canal, Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Erythroblastopenia, Exacerbation of COPD, Exacerbation of asthma, Eye inflammation caused by Cataract Surgery, Eye inflammation caused by Infection, Fissure;Anal, Herpes Zoster Keratitis, Hot Water Burns (Scalds), Hypercalcemia of Malignancy, Idiopathic Pulmonary Fibrosis (IPF), Immune Thrombocytopenia (ITP), Inflamed External Hemorrhoid, Inflamed Hemorrhoids, Internal, Inflammatory Reaction caused by susceptible Bacterial Infections, Iridocyclitis, Iritis, Itching caused by susceptible Bacterial Infections, Keratitis, Loeffler's syndrome, Lymphoma, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Multiple sclerosis exacerbation, Mycosis Fungoides (MF), Ocular Inflammation, Ophthalmia, Sympathetic, Optic Neuritis, Otic Eczema, Pemphigus, Perennial Allergic Rhinitis (PAR), Pericarditis, Pneumocystis Jirovecii Pneumonia, Polymyalgia Rheumatica (PMR), Posterior Uveitis, Posttraumatic Osteoarthritis, Proctitis, Proteinuria, Pruritus, Pruritus Ani, Psoriatic Arthritis, Pulmonary Tuberculosis (TB), Pure Red Cell Aplasia, Rash, Relapsing Polychondritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Seasonal Allergic Rhinitis, Secondary Adrenal Insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Asthma, Sjogren's Syndrome (SS), Stevens-Johnson Syndrome, Superficial punctate keratitis, Synovitis, Systemic Lupus Erythematosus, Transplanted Organ Rejection, Trichinosis, Tuberculosis (TB), Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Vasculitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Rheumatic heart disease, unspecified, Acute Tenosynovitis, Anal eczema, Bacterial skin infections, Exfoliative erythroderma, Idiopathic Bronchiolitis obliterans with organizing pneumonia, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Primary adrenocoritical insufficiency, Severe Psoriasis, Severe Seborrhoeic dermatitis, Severe alcoholic liver disease, Steroid-responsive inflammation of the eye, Subacute Bursitis, Susceptible Bacterial Infections, Symptomatic Sarcoidosis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: -

Clinical Trials

Efficacy of N-acetylcysteine With or Without Steroids in Drug Induced Liver Injury

Not Applicable

Terminated

Conditions: Drug Induced Liver Injury

Interventions: Drug: Prednisolone
Drug: N-Acetylcysteine

First Posted Date: 2016-02-19

Last Posted Date: 2017-12-18

Lead Sponsor: Institute of Liver and Biliary Sciences, India

Target Recruit Count: 4

Registration Number: NCT02686385

Locations: 🇮🇳
Institute of liver and Biliary Sciences, New Delhi, Delhi, India

Study of Ibrutinib in Combination With Rituximab-CHOP in Epstein-Barr Virus-positive Diffuse Large B-cell Lymphoma

Phase 2

Completed

Conditions: Epstein-Barr Virus-positive Diffuse Large B-cell Lymphoma

Interventions: Drug: Ibrutinib
Drug: Rituximab
Drug: Cyclophosphamide
Drug: Doxorubicin
Drug: vincristine
Drug: Prednisolone

First Posted Date: 2016-02-02

Last Posted Date: 2020-10-22

Lead Sponsor: Samsung Medical Center

Target Recruit Count: 24

Registration Number: NCT02670616

Locations: 🇰🇷
Samsung Medical Center, Seoul, Seoul, Gangnam-gu, Korea, Republic of

Validity and Security of Reh-acteoside Therapy for Patients of IgA Nephropathy

Phase 2

Conditions: IGA Nephropathy

Interventions: Drug: Reh-acteoside
Drug: Prednisolone

First Posted Date: 2016-01-25

Last Posted Date: 2016-02-02

Lead Sponsor: Sun Yat-sen University

Target Recruit Count: 75

Registration Number: NCT02662283

Locations: 🇨🇳
Department of Nephrology, 6th Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China

Comparison of Combination Disease Modifying Antirheumatic Drugs With Methotrexate Therapy in Early Rheumatoid Arthritis

Phase 4

Completed

Conditions: Rheumatoid Arthritis

Interventions: Drug: Methotrexate
Drug: Leflunomide
Drug: Hydroxychloroquine
Drug: Prednisolone
Drug: Folic Acid

First Posted Date: 2015-12-31

Last Posted Date: 2019-10-01

Lead Sponsor: Jawaharlal Institute of Postgraduate Medical Education & Research

Target Recruit Count: 186

Registration Number: NCT02644499

Locations: 🇮🇳
Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Pondicherry, Pondicherry UT, India

Stop Exogenous Allergic Alveolitis (EAA) in Childhood

Phase 2

Terminated

Conditions: Hypersensitivity Pneumonitis
Exogenous Allergic Alveolitis

Interventions: Drug: Placebo
Drug: Prednisolone

First Posted Date: 2015-12-16

Last Posted Date: 2024-12-18

Lead Sponsor: Matthias Griese

Target Recruit Count: 4

Registration Number: NCT02631603

Locations: 🇩🇪
Klinikum der Universität München, Haunersches Kinderspital, München, Bayern, Germany
🇩🇪
Universitätsklinikum Frankfurt, Pneumologie, Allergologie, Mukoviszidose, Frankfurt, Hessen, Germany
🇩🇪
Medizinische Hochschule Hannover, Hannover, Niedersachsen, Germany

and more 4 locations

Efficacy of Oral Prednisolone on Pain Reduction in Emergency Care of Acute Irreversible Pulpitis

Phase 3

Completed

Conditions: Pulpitis

Interventions: Procedure: Partial endodontic treatment under local and/or locoregional anesthesia
Drug: prednisolone

First Posted Date: 2015-12-11

Last Posted Date: 2018-12-20

Lead Sponsor: University Hospital, Bordeaux

Target Recruit Count: 5

Registration Number: NCT02629042

Locations: 🇫🇷
CHU de Bordeaux, Bordeaux, France

Effects of Oral Steroid in Mycoplasma Pneumoniae Pneumonia

Phase 4

Conditions: Mycoplasma Pneumoniae Pneumonia

Interventions: Drug: Levofloxacin
Drug: Prednisolone

First Posted Date: 2015-12-01

Last Posted Date: 2018-04-27

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 80

Registration Number: NCT02618057

Locations: 🇰🇷
Seoul National University Children's Hospital, Seoul, Korea, Republic of

A Clinical Trial to Study the Effects of Two Drugs, Lycopene and Prednisolone in Patients With Oral Lichen Planus

Phase 4

Completed

Conditions: Oral Lichen Planus

Interventions: Drug: Prednisolone
Drug: lycopene

First Posted Date: 2015-10-27

Last Posted Date: 2016-02-26

Lead Sponsor: B.P. Koirala Institute of Health Sciences

Target Recruit Count: 28

Registration Number: NCT02587117

The Glucocorticoid Low-dose Outcome in RheumatoId Arthritis Study

Phase 4

Completed

Conditions: RheumatoId Arthritis

Interventions: Drug: Prednisolone
Drug: Placebo

First Posted Date: 2015-10-23

Last Posted Date: 2023-07-18

Lead Sponsor: Amsterdam UMC, location VUmc

Target Recruit Count: 451

Registration Number: NCT02585258

Locations: 🇵🇹
Hospital de Egas Moniz, Lisboa, Portugal
🇸🇰
NURCH, Bratislava, Slovakia
🇳🇱
Meander, Amersfoort, Netherlands

and more 25 locations

Study to Evaluate the Safety for the Treatment of Inflammation Associated With Cataract Surgery

Phase 3

Completed

Conditions: Cataract

Interventions: Drug: Dexamethasone
Drug: Prednisolone

First Posted Date: 2015-09-11

Last Posted Date: 2018-08-21

Lead Sponsor: ICON Bioscience Inc

Target Recruit Count: 194

Registration Number: NCT02547623

Locations: 🇺🇸
Inland Eye Specialists, Hemet, California, United States
🇺🇸
Kislinger MD inc, Glendora, California, United States
🇺🇸
Harvard Eye Associated, Laguna Hills, California, United States

and more 7 locations

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