Prednisolone

Generic Name: Prednisolone

Brand Names: Millipred Dp 6 Day

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₈O_₅

CAS Number: 50-24-8

Unique Ingredient Identifier: 9PHQ9Y1OLM

Background: Prednisolone is a glucocorticoid similar to cortisol used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.

Prednisolone was granted FDA approval on 21 June 1955.

Indication: Prednisolone is indicated to treat endocrine, rheumatic, and hematologic disorders; collagen, dermatologic, ophthalmic, respiratory, and gastrointestinal diseases; allergic and edematous states; and other conditions like tuberculous meningitis.

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Allergic Bronchopulmonary Aspergillosis, Allergic Conjunctivitis (AC), Allergic Contact Dermatitis, Allergic Skin Reaction, Allergic corneal marginal ulcers, Alveolitis, Extrinsic Allergic, Ankylosing Spondylitis (AS), Aspiration Pneumonia, Aspiration Pneumonitis, Atopic Dermatitis, Bell's Palsy, Berylliosis, Bullous dermatitis herpetiformis, Burns, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Corneal injuries, Corneal ulceration, Crohn's Disease (CD), Cyclitis, Dermatomyositis (DM), Dermatosis of the Ear Canal, Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Erythroblastopenia, Exacerbation of COPD, Exacerbation of asthma, Eye inflammation caused by Cataract Surgery, Eye inflammation caused by Infection, Fissure;Anal, Herpes Zoster Keratitis, Hot Water Burns (Scalds), Hypercalcemia of Malignancy, Idiopathic Pulmonary Fibrosis (IPF), Immune Thrombocytopenia (ITP), Inflamed External Hemorrhoid, Inflamed Hemorrhoids, Internal, Inflammatory Reaction caused by susceptible Bacterial Infections, Iridocyclitis, Iritis, Itching caused by susceptible Bacterial Infections, Keratitis, Loeffler's syndrome, Lymphoma, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Multiple sclerosis exacerbation, Mycosis Fungoides (MF), Ocular Inflammation, Ophthalmia, Sympathetic, Optic Neuritis, Otic Eczema, Pemphigus, Perennial Allergic Rhinitis (PAR), Pericarditis, Pneumocystis Jirovecii Pneumonia, Polymyalgia Rheumatica (PMR), Posterior Uveitis, Posttraumatic Osteoarthritis, Proctitis, Proteinuria, Pruritus, Pruritus Ani, Psoriatic Arthritis, Pulmonary Tuberculosis (TB), Pure Red Cell Aplasia, Rash, Relapsing Polychondritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Seasonal Allergic Rhinitis, Secondary Adrenal Insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Asthma, Sjogren's Syndrome (SS), Stevens-Johnson Syndrome, Superficial punctate keratitis, Synovitis, Systemic Lupus Erythematosus, Transplanted Organ Rejection, Trichinosis, Tuberculosis (TB), Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Vasculitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Rheumatic heart disease, unspecified, Acute Tenosynovitis, Anal eczema, Bacterial skin infections, Exfoliative erythroderma, Idiopathic Bronchiolitis obliterans with organizing pneumonia, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Primary adrenocoritical insufficiency, Severe Psoriasis, Severe Seborrhoeic dermatitis, Severe alcoholic liver disease, Steroid-responsive inflammation of the eye, Subacute Bursitis, Susceptible Bacterial Infections, Symptomatic Sarcoidosis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: -

Clinical Trials

LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia

Phase 4

Completed

Conditions: Acute Lymphoblastic Leukemia

First Posted Date: 2007-09-10

Last Posted Date: 2014-10-28

Lead Sponsor: PETHEMA Foundation

Target Recruit Count: 40

Registration Number: NCT00526409

Locations: 🇪🇸
Hospital Niño Jesús, Madrid, Spain
🇪🇸
Hospital materno Infantil vall d'Hebrón, Barcelona, Spain
🇪🇸
Hospital Infantil Carlos Haya, Málaga, Spain

and more 1 locations

CRx-102 Osteoarthritis Multicenter Evaluation Trial

Phase 2

Terminated

Conditions: Knee Osteoarthritis

Interventions: Drug: CRx-102 (2.7/90)
Drug: CRx-102 (2.7/180)
Drug: Placebo
Drug: Prednisolone
Drug: CRx-102 (2.7/360)

First Posted Date: 2007-08-29

Last Posted Date: 2014-04-29

Lead Sponsor: Zalicus

Target Recruit Count: 279

Registration Number: NCT00521989

Combination Chemotherapy With or Without Bortezomib in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma

Phase 2

Completed

Conditions: Lymphoma

Interventions: Drug: bortezomib
Drug: cyclophosphamide
Drug: doxorubicin hydrochloride
Drug: prednisolone
Drug: vincristine sulfate
Other: questionnaire administration
Procedure: quality-of-life assessment

First Posted Date: 2007-08-09

Last Posted Date: 2014-11-05

Lead Sponsor: University Hospital Plymouth NHS Trust

Target Recruit Count: 50

Registration Number: NCT00513955

Locations: 🇬🇧
Royal Victoria Infirmary, Newcastle-Upon-Tyne, England, United Kingdom
🇬🇧
Birmingham Heartlands Hospital, Birmingham, England, United Kingdom
🇬🇧
Addenbrooke's Hospital, Cambridge, England, United Kingdom

and more 22 locations

E3-Hormone Refractory Prostrate Cancer Taxotere Combination

Phase 2

Completed

Conditions: Prostate Cancer
Metastatic
Hormone Refractory

First Posted Date: 2007-07-10

Last Posted Date: 2016-10-07

Lead Sponsor: Sanofi

Target Recruit Count: 86

Registration Number: NCT00498797

Locations: 🇸🇪
Research Site, Uppsala, Sweden
🇧🇷
Research site, Rio de Janeiro, Brazil

Efficacy of Systemic Glucocorticoid in the Treatment of Wheezing in Children

Phase 4

Conditions: Wheezing

First Posted Date: 2007-07-02

Last Posted Date: 2007-07-02

Lead Sponsor: University of Turku

Target Recruit Count: 300

Registration Number: NCT00494624

Locations: 🇫🇮
Turku University Hospital, Turku, Finland

A Study to Compare the Efficacy and Safety of FK506MR vs Prograf® in Patients Undergoing Kidney Transplantation

Phase 3

Completed

Conditions: Kidney Transplantation

Interventions: Drug: FK506MR
Drug: Prograf
Drug: Mycophenolate Mofetil
Drug: Methylprednisolone
Drug: Prednisolone

First Posted Date: 2007-06-04

Last Posted Date: 2016-02-24

Lead Sponsor: Astellas Pharma Inc

Target Recruit Count: 240

Registration Number: NCT00481819

Locations: 🇨🇳
2 Sites, Shanghai, Shanghai, China
🇨🇳
3 Sites, Beijing, Beijing, China

High Dose Dexamethasone Vs. Conventional Dose Prednisolone in Adult ITP

Phase 3

Completed

Conditions: Idiopathic Thrombocytopenic Purpura

First Posted Date: 2007-03-23

Last Posted Date: 2011-01-13

Lead Sponsor: Cooperative Study Group A for Hematology

Target Recruit Count: 157

Registration Number: NCT00451594

Locations: 🇰🇷
Asan Medical Center, Seoul, Songpa-gu, Korea, Republic of

Prednisolone vs. Ciclosporine in Severe Atopic Eczema

Phase 4

Completed

Conditions: Atopic Dermatitis

Interventions: Drug: Ciclosporine A
Drug: Prednisolone

First Posted Date: 2007-03-08

Last Posted Date: 2010-10-29

Lead Sponsor: Technische Universität Dresden

Target Recruit Count: 66

Registration Number: NCT00445081

Locations: 🇩🇪
Dept. of Dermatology, Medical Faculty, TU Dresden, Dresden, Germany
🇦🇹
University Hospital of Dermatology and Venerology Graz, Graz, Austria
🇩🇪
Dpt. of Dermatology, Medical Faculty Eppendorf, Hamburg, Germany

and more 2 locations