Prednisolone

Generic Name: Prednisolone

Brand Names: Millipred Dp 6 Day

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₈O_₅

CAS Number: 50-24-8

Unique Ingredient Identifier: 9PHQ9Y1OLM

Background: Prednisolone is a glucocorticoid similar to cortisol used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.

Prednisolone was granted FDA approval on 21 June 1955.

Indication: Prednisolone is indicated to treat endocrine, rheumatic, and hematologic disorders; collagen, dermatologic, ophthalmic, respiratory, and gastrointestinal diseases; allergic and edematous states; and other conditions like tuberculous meningitis.

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Allergic Bronchopulmonary Aspergillosis, Allergic Conjunctivitis (AC), Allergic Contact Dermatitis, Allergic Skin Reaction, Allergic corneal marginal ulcers, Alveolitis, Extrinsic Allergic, Ankylosing Spondylitis (AS), Aspiration Pneumonia, Aspiration Pneumonitis, Atopic Dermatitis, Bell's Palsy, Berylliosis, Bullous dermatitis herpetiformis, Burns, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Corneal injuries, Corneal ulceration, Crohn's Disease (CD), Cyclitis, Dermatomyositis (DM), Dermatosis of the Ear Canal, Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Erythroblastopenia, Exacerbation of COPD, Exacerbation of asthma, Eye inflammation caused by Cataract Surgery, Eye inflammation caused by Infection, Fissure;Anal, Herpes Zoster Keratitis, Hot Water Burns (Scalds), Hypercalcemia of Malignancy, Idiopathic Pulmonary Fibrosis (IPF), Immune Thrombocytopenia (ITP), Inflamed External Hemorrhoid, Inflamed Hemorrhoids, Internal, Inflammatory Reaction caused by susceptible Bacterial Infections, Iridocyclitis, Iritis, Itching caused by susceptible Bacterial Infections, Keratitis, Loeffler's syndrome, Lymphoma, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Multiple sclerosis exacerbation, Mycosis Fungoides (MF), Ocular Inflammation, Ophthalmia, Sympathetic, Optic Neuritis, Otic Eczema, Pemphigus, Perennial Allergic Rhinitis (PAR), Pericarditis, Pneumocystis Jirovecii Pneumonia, Polymyalgia Rheumatica (PMR), Posterior Uveitis, Posttraumatic Osteoarthritis, Proctitis, Proteinuria, Pruritus, Pruritus Ani, Psoriatic Arthritis, Pulmonary Tuberculosis (TB), Pure Red Cell Aplasia, Rash, Relapsing Polychondritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Seasonal Allergic Rhinitis, Secondary Adrenal Insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Asthma, Sjogren's Syndrome (SS), Stevens-Johnson Syndrome, Superficial punctate keratitis, Synovitis, Systemic Lupus Erythematosus, Transplanted Organ Rejection, Trichinosis, Tuberculosis (TB), Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Vasculitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Rheumatic heart disease, unspecified, Acute Tenosynovitis, Anal eczema, Bacterial skin infections, Exfoliative erythroderma, Idiopathic Bronchiolitis obliterans with organizing pneumonia, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Primary adrenocoritical insufficiency, Severe Psoriasis, Severe Seborrhoeic dermatitis, Severe alcoholic liver disease, Steroid-responsive inflammation of the eye, Subacute Bursitis, Susceptible Bacterial Infections, Symptomatic Sarcoidosis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: -

Clinical Trials

A Multicentre, Parallel Arm, Open-label Trial of Frontline R-CHOP/Pola-RCHP and Glofitamab in Younger, Higher Risk Patients With Diffuse Large B Cell Lymphoma (DLBCL)

Phase 1

Active, not recruiting

Conditions: Diffuse Large B Cell Lymphoma
High-grade B-cell Lymphoma

Interventions: Drug: Rituximab
Drug: Cyclophosphamide
Drug: Doxorubicin
Drug: Vincristine
Drug: Prednisolone
Drug: Glofitamab
Drug: Polatuzumab vedotin

First Posted Date: 2021-06-07

Last Posted Date: 2024-08-12

Lead Sponsor: Peter MacCallum Cancer Centre, Australia

Target Recruit Count: 80

Registration Number: NCT04914741

Locations: 🇦🇺
Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
🇦🇺
St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia
🇦🇺
Alfred Hospital, Melbourne, Victoria, Australia

and more 12 locations

High Dose Steroids in Children With Stroke

Phase 3

Recruiting

Conditions: Paediatric Stroke

Interventions: Drug: Methylprednisolone
Drug: Prednisolone

First Posted Date: 2021-05-05

Last Posted Date: 2024-07-08

Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Target Recruit Count: 70

Registration Number: NCT04873583

Locations: 🇫🇷
Hôpital Roger Salengro, CHRU de Lille, Lille, France
🇩🇪
LMU Klinikum, München, Bayern, Germany
🇩🇪
Charité-Universitätsmedizin Berlin, Berlin, Germany

and more 29 locations

TReatment for ImmUne Mediated PathopHysiology

Phase 2

Recruiting

Conditions: Fulminant Hepatic Failure
Immune Dysregulation
Hepatic Encephalopathy
Acute Liver Injury
Acute Liver Failure

Interventions: Drug: High-dose methylprednisolone
Drug: Equine anti-thymocyte globulin
Drug: Placebo for prednisolone
Drug: Placebo for infusions
Drug: Prednisolone
Drug: Diphenhydramine
Drug: Methylprednisolone

First Posted Date: 2021-04-27

Last Posted Date: 2024-07-01

Lead Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Target Recruit Count: 163

Registration Number: NCT04862221

Locations: 🇺🇸
Emory Children's Healthcare of Atlanta, Atlanta, Georgia, United States
🇺🇸
Cleveland Clinic Children's, Cleveland, Ohio, United States
🇺🇸
The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States

and more 19 locations

Vedolizumab for Immune Mediated Colitis

Phase 2

Recruiting

Conditions: Immune-Mediated Colitis

Interventions: Drug: Vedolizumab
Drug: Prednisolone

First Posted Date: 2021-03-15

Last Posted Date: 2022-08-17

Lead Sponsor: University of Copenhagen

Target Recruit Count: 82

Registration Number: NCT04797325

Locations: 🇩🇰
Herlev University Hospital, Herlev, Denmark

A 3 Arm Randomized Study on Health-related QoL of Elderly Patients With Advanced Soft Tissue Sarcoma

Phase 3

Terminated

Conditions: Advanced Soft-tissue Sarcoma

Interventions: Drug: Cyclophosphamide Oral Product
Drug: Doxorubicin
Drug: Prednisolone
Drug: Prednisone

First Posted Date: 2021-03-03

Last Posted Date: 2024-02-22

Lead Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

Target Recruit Count: 14

Registration Number: NCT04780464

Locations: 🇯🇴
King Hussein Cancer Center, Amman, Jordan
🇨🇾
Bank Of Cyprus Oncology Centre, Nicosia, Cyprus

Prevention of Glucocorticoid Induced Impairment of Bone Metabolism

Not Applicable

Completed

Conditions: Bone Loss

Interventions: Dietary Supplement: Lactobacillus reuteri ATCC PTA 6475 (L. reuteri 6475)
Drug: Prednisolone

First Posted Date: 2021-02-23

Last Posted Date: 2023-02-06

Lead Sponsor: Sahlgrenska University Hospital, Sweden

Target Recruit Count: 50

Registration Number: NCT04767711

Locations: 🇸🇪
Geriatric Medicine, Sahlgrenska University Hospital, Mölndal, Sweden

Comparison Between Prednisolone and Dexamethasone on Mortality in Patients on Oxygen Therapy, With CoViD-19

Phase 3

Completed

Conditions: Coronavirus Infection

Interventions: Drug: DEXAMETHASONE
Drug: PREDNISOLONE

First Posted Date: 2021-02-21

Last Posted Date: 2024-05-06

Lead Sponsor: Hôpital NOVO

Target Recruit Count: 89

Registration Number: NCT04765371

Locations: 🇫🇷
Department of Infectious Medicine, Hospital of Gonesse, Gonesse, France
🇫🇷
Department of Pneumology and Infectious Diseases, Hospital of Saint-Quentin, Saint-Quentin, France
🇫🇷
Department of Emergency, Hospital Victor Dupouy, Argenteuil, France

and more 5 locations

Nivolumab in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma

First Posted Date: 2021-02-18

Last Posted Date: 2024-12-20

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 244

Registration Number: NCT04759586

Locations: 🇺🇸
Valley Children's Hospital, Madera, California, United States
🇺🇸
Children's Hospital of Alabama, Birmingham, Alabama, United States
🇺🇸
USA Health Strada Patient Care Center, Mobile, Alabama, United States

and more 226 locations