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Diphenoxylate Hydrochloride and Atropine Sulfate

Diphenoxylate Hydrochloride and Atropine Sulfate Tablets, for oral use C-V

Approved
Approval ID

83bcc2fb-6fb0-4f0e-8e66-592d327684ec

Product Type

HUMAN PRESCRIPTION DRUG LABEL

Effective Date

Sep 12, 2023

Manufacturers
FDA

Greenstone LLC

DUNS: 825560733

FDA

Mylan Pharmaceuticals Inc.

DUNS: 059295980

Products 1

Detailed information about drug products covered under this FDA approval, including NDC codes, dosage forms, ingredients, and administration routes.

Diphenoxylate Hydrochloride and Atropine Sulfate

Product Details

FDA regulatory identification and product classification information

FDA Identifiers
NDC Product Code59762-1061
Application NumberNDA012462
Product Classification
M
Marketing Category
C73605
G
Generic Name
Diphenoxylate Hydrochloride and Atropine Sulfate
Product Specifications
Route of AdministrationORAL
Effective DateSeptember 12, 2023
FDA Product Classification

INGREDIENTS (8)

ATROPINE SULFATEActive
Quantity: 0.025 mg in 1 1
Code: 03J5ZE7KA5
Classification: ACTIB
ACACIAInactive
Code: 5C5403N26O
Classification: IACT
STARCH, CORNInactive
Code: O8232NY3SJ
Classification: IACT
MAGNESIUM STEARATEInactive
Code: 70097M6I30
Classification: IACT
SORBITOLInactive
Code: 506T60A25R
Classification: IACT
SUCROSEInactive
Code: C151H8M554
Classification: IACT
TALCInactive
Code: 7SEV7J4R1U
Classification: IACT
DIPHENOXYLATE HYDROCHLORIDEActive
Quantity: 2.5 mg in 1 1
Code: W24OD7YW48
Classification: ACTIB

Drug Labeling Information

PACKAGE LABEL.PRINCIPAL DISPLAY PANEL

LOINC: 51945-4Updated: 9/12/2023

PRINCIPAL DISPLAY PANEL - 100 Tablet Bottle Label

NDC 59762-1061-1
100 Tablets

GREENSTONE® BRAND

diphenoxylate
hydrochloride
and atropine
sulfate tablets,
USP
CV

2.5 mg/0.025 mg*

Rx only

PRINCIPAL DISPLAY PANEL - 100 Tablet Bottle Label

DESCRIPTION SECTION

LOINC: 34089-3Updated: 9/12/2023

DESCRIPTION

Each diphenoxylate hydrochloride and atropine sulfate tablet contains:

2.5 mg of diphenoxylate hydrochloride USP (equivalent to 2.3 mg of diphenoxylate) and 0.025 mg of atropine sulfate USP (equivalent to 0.01 mg of atropine)

Diphenoxylate hydrochloride, an antidiarrheal, is ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotate monohydrochloride and has the following structural formula:

Chemical Structure

Atropine sulfate, an anticholinergic, is endo-(±)-α-(hydroxymethyl) benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1] oct-3-yl ester sulfate (2:1) (salt) monohydrate and has the following structural formula:

Chemical Structure

A subtherapeutic amount of atropine sulfate is present to discourage deliberate overdosage.

Inactive ingredients of diphenoxylate hydrochloride and atropine sulfate tablets include acacia, corn starch, magnesium stearate, sorbitol, sucrose, and talc.

SPL UNCLASSIFIED SECTION

LOINC: 42229-5Updated: 9/12/2023

This product's label may have been updated. For current full prescribing information, please visit www.greenstonellc.com.

Greenstone Logo

LAB-0517-4.0
Revised March 2018

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Diphenoxylate Hydrochloride and Atropine Sulfate - FDA Drug Approval Details