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SAJAZIR

These highlights do not include all the information needed to use SAJAZIR™ (icatibant) safely and effectively. See full prescribing information for SAJAZIR™.SAJAZIR™ (icatibant) injection, for subcutaneous useInitial U.S. Approval: 2011

Approved
Approval ID

1756aca0-21a1-4898-8d6c-9666738db45c

Product Type

HUMAN PRESCRIPTION DRUG LABEL

Effective Date

Sep 7, 2023

Manufacturers
FDA

Cycle Pharmaceuticals Ltd-Uk

DUNS: 218215530

Products 1

Detailed information about drug products covered under this FDA approval, including NDC codes, dosage forms, ingredients, and administration routes.

ICATIBANT

Product Details

FDA regulatory identification and product classification information

FDA Identifiers
NDC Product Code70709-013
Application NumberANDA212446
Product Classification
M
Marketing Category
C73584
G
Generic Name
ICATIBANT
Product Specifications
Route of AdministrationSUBCUTANEOUS
Effective DateMay 31, 2023
FDA Product Classification

INGREDIENTS (5)

ICATIBANT ACETATEActive
Quantity: 30 mg in 3 mL
Code: 325O8467XK
Classification: ACTIM
ACETIC ACIDInactive
Quantity: 3.96 mg in 3 mL
Code: Q40Q9N063P
Classification: IACT
SODIUM CHLORIDEInactive
Quantity: 22.35 mg in 3 mL
Code: 451W47IQ8X
Classification: IACT
SODIUM HYDROXIDEInactive
Quantity: 1.92 mg in 3 mL
Code: 55X04QC32I
Classification: IACT
WATERInactive
Code: 059QF0KO0R
Classification: IACT

Drug Labeling Information

DRUG INTERACTIONS SECTION

LOINC: 34073-7Updated: 5/20/2022

7 DRUG INTERACTIONS

7.1 ACE Inhibitors

Icatibant is a bradykinin B2 receptor antagonist and thereby has the potential to have a pharmacodynamic interaction with ACE inhibitors where icatibant may attenuate the antihypertensive effect of ACE inhibitors. Clinical trials to date have excluded subjects taking ACE inhibitors.

HOW SUPPLIED SECTION

LOINC: 34069-5Updated: 5/20/2022

16 HOW SUPPLIED/STORAGE AND HANDLING

16.1 How Supplied

SAJAZIR (icatibant) injection is supplied as a single-dose, prefilled syringe for subcutaneous administration. Each syringe delivers 3 mL of a sterile solution of icatibant 30 mg (as icatibant acetate). Each glass syringe has a bromobutyl plunger stopper, which is not made of latex natural rubber.

SAJAZIR is available in cartons containing one single-dose, prefilled syringe and one 25 G Luer lock needle. NDC 70709-013-01.

SAJAZIR is also available in a pack containing 3 cartons; each carton contains one single-dose, prefilled syringe and one 25 G Luer lock needle. NDC 70709-013-03.

16.2 Storage and Handling

Keep out of the reach of children.

Store between 2 - 25° C (36 - 77° F).

Do not freeze.

Store in carton until time of administration.

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SAJAZIR - FDA Drug Approval Details