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FDA Approval

Clotrimazole and Betamethasone Dipropionate

FDA-approved pharmaceutical product with comprehensive regulatory information, manufacturing details, and complete labeling documentation.

FDA Approval Summary

Company
Proficient Rx LP
DUNS: 079196022
Effective Date
January 1, 2021
Labeling Type
HUMAN PRESCRIPTION DRUG LABEL
Clotrimazole(10 mg in 1 g)
Betamethasone(0.5 mg in 1 g)

Manufacturing Establishments1

FDA-registered manufacturing facilities and establishments involved in the production, packaging, or distribution of this drug product.

Proficient Rx LP

Proficient Rx LP

079196022

Products1

Detailed information about drug products covered under this FDA approval, including NDC codes, dosage forms, ingredients, and administration routes.

Clotrimazole and Betamethasone Dipropionate

Product Details

NDC Product Code
71205-524
Application Number
ANDA202894
Marketing Category
ANDA (C73584)
Route of Administration
TOPICAL
Effective Date
January 1, 2021
Code: G07GZ97H65Class: ACTIBQuantity: 10 mg in 1 g
Code: 826Y60901UClass: ACTIMQuantity: 0.5 mg in 1 g
CETOSTEARYL ALCOHOLInactive
Code: 2DMT128M1SClass: IACT
BENZYL ALCOHOLInactive
Code: LKG8494WBHClass: IACT
SODIUM PHOSPHATE, MONOBASIC, MONOHYDRATEInactive
Code: 593YOG76RNClass: IACT
CETEARETH-30Inactive
Code: 1R9DCZ5FOXClass: IACT
MINERAL OILInactive
Code: T5L8T28FGPClass: IACT
PHOSPHORIC ACIDInactive
Code: E4GA8884NNClass: IACT
SODIUM HYDROXIDEInactive
Code: 55X04QC32IClass: IACT
PETROLATUMInactive
Code: 4T6H12BN9UClass: IACT
PROPYLENE GLYCOLInactive
Code: 6DC9Q167V3Class: IACT
WATERInactive
Code: 059QF0KO0RClass: IACT

Drug Labeling Information

Complete FDA-approved labeling information including indications, dosage, warnings, contraindications, and other essential prescribing details.

INDICATIONS & USAGE SECTION

Highlight: Clotrimazole and betamethasone dipropionate cream contains a combination of clotrimazole, an azole antifungal, and betamethasone dipropionate, a corticosteroid, and is indicated for the topical treatment of symptomatic inflammatory tinea pedis, tinea cruris, and tinea corporis due to Epidermophyton floccosum, Trichophyton mentagrophytes, and Trichophyton rubrum in patients 17 years and older. (1)

1 INDICATIONS AND USAGE

Clotrimazole and betamethasone dipropionate cream is a combination of an azole antifungal and corticosteroid and is indicated for the topical treatment of symptomatic inflammatory tinea pedis, tinea cruris, and tinea corporis due to Epidermophyton floccosum, Trichophyton mentagrophytes, and Trichophyton rubrum in patients 17 years and older.

DOSAGE & ADMINISTRATION SECTION

Highlight:

 Tinea pedis: Apply a thin film to the affected skin areas twice a day for 2 weeks. Do not use longer than 4 weeks. (2) 

 Tinea cruris and tinea corporis: Apply a thin film to the affected skin area twice a day for 1 week. Do not use longer than 2 weeks. (2) 

Do not use with occlusive dressings unless directed by a physician. (2) 

Not for ophthalmic, oral or intravaginal use. (2)

2 DOSAGE AND ADMINISTRATION

Treatment of tinea corporis or tinea cruris:

Apply a thin film of clotrimazole and betamethasone dipropionate cream into the affected skin areas twice a day for one week. 

Do not use more than 45 grams per week. Do not use with occlusive dressings. 

If a patient shows no clinical improvement after 1 week of treatment with clotrimazole and betamethasone dipropionate cream, the diagnosis should be reviewed. 

Do not use longer than 2 weeks. 

Treatment of tinea pedis:

Gently massage a sufficient amount of clotrimazole and betamethasone dipropionate cream into the affected skin areas twice a day for two weeks. 

Do not use more than 45 grams per week. Do not use with occlusive dressings. 

If a patient shows no clinical improvement after 2 weeks of treatment with clotrimazole and betamethasone dipropionate cream, the diagnosis should be reviewed. 

Do not use longer than 4 weeks. 

Clotrimazole and betamethasone dipropionate cream is for topical use only. It is not for oral, ophthalmic, or intravaginal use.

Avoid contact with eyes. Wash hands after each application.

DOSAGE FORMS & STRENGTHS SECTION

Highlight: Cream, 1%/0.05%. (3)

Each gram of Clotrimazole and Betamethasone Dipropionate Cream USP, 1%/0.05% (base) contains 10 mg of clotrimazole, USP and 0.643 mg of betamethasone dipropionate, USP (equivalent to 0.5 mg of betamethasone). (3)

3 DOSAGE FORMS AND STRENGTHS

Cream, 1%/0.05%. Each gram of Clotrimazole and Betamethasone Dipropionate Cream USP, 1%/0.05% (base) contains 10 mg of clotrimazole, USP and 0.643 mg of betamethasone dipropionate, USP (equivalent to 0.5 mg of betamethasone) in a white to off-white, uniform and smooth cream base.


CONTRAINDICATIONS SECTION

Highlight: None. (4)

4 CONTRAINDICATIONS

None.


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