QUPRON TABLETS 250 mg

TABLET, FILM COATED

**【DOSAGE AND ADMINISTRATION】** 1. Usually for adults, administer 250~500mg at meal intervals twice a day. In severe mixed infections, administer up to 750mg twice a day. In acute infections, usually treat for 5 to 10 days. After disappearance of symptoms, further administration is required at least for 3 days. 2. In patients with severe renal disorder, it should be administered according to the following dosage and administration.  When only the concentration of serum creatinine clearance is known, the patient’s creatinine clearance can be estimated by using the following formulas:  In patient with severe cardiac failure and infections, 750mg can be administered once, but careful monitoring is required and the ciprofloxacin concentration should be periodically estimated. At that time, the peak serum concentration (obtained 1~2 hours after administration) should range from 2~4mcg/ml. 3. Dosage may be adjusted according to causative organisms and severity of symptom.