ENDOXAN TABLET 50 mg

TABLET, SUGAR COATED

**Posology and method of administration** ENDOXAN should only be administered by experienced oncologists. The dosage must be adapted to each patient individually. Unless otherwise prescribed the following dosages are recommended: ENDOXAN, sugar-coated tablets: For continuous therapy 1–4 tablets (50–200 mg) daily; if necessary, more tablets may be taken. The dose recommendations given mainly apply to the treatment with cyclophosphamide as a monotherapy. In combination with other cytostatics of similar toxicity, a dose reduction or extension of the therapy-free intervals may be necessary. _Recommendations for dose reduction in patients with myelosuppression_  _Recommendations for dose adjustment in patients with hepatic and renal insufficiency_ Severe hepatic or renal insufficiency requires a dose reduction. A dose reduction of 25% for serum bilirubin from 3.1 to 5 mg/100 ml and of 50% for a glomerular filtration rate below 10 ml/minute is recommended. Cyclophosphamide is dialysable. ENDOXAN, sugar-coated tablets ENDOXAN sugar-coated tablets should be administered in the morning. During or immediately after the administration adequate amounts of fluid should be ingested. It is important to ensure that the patient empties his/her bladder at regular intervals. Duration of therapy and intervals will depend on the indication, the applied combination chemotherapy schedule, the patient's general state of health, the laboratory parameters and the recovery of blood cell counts. **Instructions for use and handling** The handling and preparation of ENDOXAN should always be in accordance with the safety precautions used for handling of cytotoxic agents.