PROPYLTHIOURACIL TABLET BP 50 mg

TABLET

**4.2.Posology and method of administration** Propylthiouracil is administered by the oral route. Management of Hyperthyroidism Adults The initial dose of propylthiouracil is between 300mg and 600mg given as a single daily dose. This dose should be maintained until the patient euthyroid. The dose should then be reduced gradually to a maintenance dose of between 50mg and 150mg, taken as a single daily dose. Daily doses can be divided if preferred. Children: Children aged 6 – 10 years: Initial dose of 50–150mg daily Children over 10 years:Initial dose of 150–300mg (or 150mg/m2) daily Maintenance dose is determined by the patient’s response. Preparation for Surgery As for management of hyperthyroidism, until the patient becomes euthyroid. Adjunct to Radioactive Iodine Therapy As for management of hyperthyroidism, for several weeks prior to radio-iodine treatment. Withdraw propylthiouracil 2 to 4 days before irradiation. The dosage of radio-iodine may need to be adjusted because propylthiouracil may have a radioprotective effect. Management of Thyrotoxic Crisis 200mg every 4 to 6 hours for the first 24 hours, decrease the dose as the crisis subsides. Elderly The adult dose should apply, but caution is advised in the presence of renal or hepatic impairment, where a dosage reduction may be justified. Renal impairment Decrease the dose of propylthiouracil in renal failure. If the glomerular filtration rate is 10–50ml/min, decrease dose by 25%. If the GFR is <10ml/min. decrease dose by 50%.